In rats exposed to zoledronic acid, teriparatide before tooth extraction increased osteoclast numbers compared with control.
In plain wordsIn rats exposed to zoledronic acid, teriparatide before tooth extraction increased osteoclast numbers compared with control.
- Peptide
- Teriparatide (PTH 1-34)
- Outcome
- IncreaseOsteoclast numbers before extraction regimen
- Study
ratn: not reported in source
Zoledronic acid exposure with tooth extraction and maxillary bone defects- Comparator
- Zoledronic acid control
- Outcome group
- Bone and joint · Musculoskeletal
- Studied dose
- Dose not stated · subcutaneousAs given in this study (rat).
Source sentences
The osteoclast numbers were larger in the experimental groups (teriparatide administered before and immediately after tooth extraction) than in the control group (administered zoledronic acid).
2 context sentences(design, population, supporting numbers)
There were significant differences in osteoclast numbers and in the inflammatory phase of bone healing between the experimental and control groups (P < .05).
Rats (n = 80) that had been injected intraperitoneally with zoledronic acid for 7 weeks were used. Maxillary first molar extractions and bone defects were established in the same region in the eighth week. Teriparatide was administered subcutaneously to prevent osteonecrosis.