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Study · In vitro (cells) · 2015

3 results

Ghrelin receptor in Japanese fire belly newt, Cynops pyrrhogaster.

Kaiya H, Kangawa K, Miyazato M

Comparative biochemistry and physiology. Part B, Biochemistry & molecular biology11 Jul 2015Cited by 5 (Europe PMC)

PMID26172570 (opens in a new tab)DOI10.1016/j.cbpb.2015.07.001 (opens in a new tab)PepBankPUB-26172570
Publisher pagePubMedAsk about this study
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Summary

The text of this summary is not shown here, because the article license does not allow reuse. Read it at the source (opens in a new tab)

Text rights: Publisher copyright. Results still quote short attributed sentences.

Results from this study3

3 results from studies that gave the peptide. No result from this study comes from people.

  1. 01LabIn vitro (cells)Activity measurement

    In HEK cells expressing newt GHS-R1a, GHRP‑6 increased intracellular calcium concentration.

    In plain wordsIn cells with newt ghrelin receptors, GHRP‑6 increased calcium levels inside cells.

    Peptide
    GHRP-6
    Outcome
    IncreaseIntracellular calcium
    Study

    humann: not reported in source

    HEK 293 cells expressing newt GHS-R1a
    Outcome group
    Receptor activity and mechanism · Pharmacology
    Studied dose
    Dose not stated

    Source sentences

    Summary
    In functional analyses, homologous newt ghrelin, heterologous bullfrog and rat ghrelin, and a GHS-R1a agonist, GHRP-6 increased intracellular Ca(2+) concentration in human embryonic kidney (HEK) 293 cells stably expressed newt GHS-R1a.
  2. 02LabIn vitro (cells)Activity measurement

    In newt receptor functional analyses, GHRP‑6 had affinity similar to bullfrog ghrelin.

    In plain wordsIn lab tests, GHRP‑6 bound newt receptors with affinity similar to bullfrog ghrelin.

    Peptide
    GHRP-6
    Outcome
    No significant changeReceptor affinity
    Study

    humann: not reported in source

    HEK 293 cells expressing newt GHS-R1a
    Comparator
    Bullfrog ghrelin
    Outcome group
    Receptor activity and mechanism · Pharmacology
    Studied dose
    Dose not stated

    Source sentences

    Summary
    GHRP-6 has a similar affinity to bullfrog ghrelin.
    1 context sentence
    Summary · context
    In functional analyses, homologous newt ghrelin, heterologous bullfrog and rat ghrelin, and a GHS-R1a agonist, GHRP-6 increased intracellular Ca(2+) concentration in human embryonic kidney (HEK) 293 cells stably expressed newt GHS-R1a.
  3. 03LabIn vitro (cells)Activity measurement

    In HEK 293 cells, responsiveness to tested agonists including GHRP‑6 was much greater for short-chain than long-chain newt GHS-R1a.

    In plain wordsIn cells, the short-chain newt receptor responded much more than the long-chain receptor to tested agonists, including GHRP‑6.

    Peptide
    GHRP-6
    Outcome
    IncreaseResponsiveness of short-chain versus long-chain receptor
    Study

    humann: not reported in source

    HEK 293 cells expressing newt GHS-R1a
    Comparator
    Long-chain newt GHS-R1a
    Outcome group
    Receptor activity and mechanism · Pharmacology
    Studied dose
    Dose not stated

    Source sentences

    Summary
    The responsiveness was much greater in the short-chain receptor than in the long-chain receptor.
    1 context sentence
    Summary · context
    In functional analyses, homologous newt ghrelin, heterologous bullfrog and rat ghrelin, and a GHS-R1a agonist, GHRP-6 increased intracellular Ca(2+) concentration in human embryonic kidney (HEK) 293 cells stably expressed newt GHS-R1a.

AI wrote and checked these results. AI can make mistakes, so check important results against the source.

Version history

PepBank keeps every version of the data on this study. Status changes from Retraction Watch, Europe PMC and Crossref are listed with their source.

  1. Version 2Current

    21 Oct 2026, 15:58 UTC

    Study results updated

  2. Version 1

    9 Oct 2026, 03:13 UTC

    First added · source update from Europe PMC

Subjects

Terms as the source lists them.

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