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Study · Randomized controlled trial · 2015

2 results

Does oxytocin affect mind-reading? A replication study.

Radke S, de Bruijn ER

Psychoneuroendocrinology19 Jun 2015Cited by 66 (Europe PMC)

PMID26142239 (opens in a new tab)DOI10.1016/j.psyneuen.2015.06.006 (opens in a new tab)PepBankPUB-26142239
Publisher pagePubMedAsk about this study
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Summary

The text of this summary is not shown here, because the article license does not allow reuse. Read it at the source (opens in a new tab)

Text rights: Publisher copyright. Results still quote short attributed sentences.

Results from this study2

2 results from studies that gave the peptide. 2 results from people.

  1. 01HumanRandomized controlled trialEfficacy outcome

    In a replication trial, oxytocin did not affect mind-reading performance on the RMET, in general or by item characteristics.

    In plain wordsOxytocin did not improve the ability to read others' mental states from the eyes, compared with placebo.

    Peptide
    Oxytocin
    Outcome
    No significant changeMind-reading performance (RMET)
    Study

    n: not reported in source

    Comparator
    Placebo
    Outcome group
    Social behavior and cognition · Nervous system and cognition
    Studied dose
    Dose not stated

    Source sentences

    Summary
    Oxytocin did not affect mind-reading, neither in general nor when considering specific item characteristics.
    1 context sentence
    Summary · context
    Following the original design of Domes et al. (2007), the aim of the current study was to replicate and extend previous findings by thoroughly investigating the impact of oxytocin administration on RMET performance.
  2. 02HumanRandomized controlled trialEfficacy outcome

    Individuals low in emotional empathy showed greater improvement in RMET performance after oxytocin than after placebo.

    In plain wordsPeople low in emotional empathy improved more on the mind-reading test after oxytocin than after placebo.

    Peptide
    Oxytocin
    Outcome
    MixedRMET improvement by emotional empathy
    Study

    n: not reported in source

    Comparator
    Placebo
    Outcome group
    Social behavior and cognition · Nervous system and cognition
    Studied dose
    Dose not stated

    Source sentences

    Summary
    An association between oxytocin-induced changes in RMET performance and emotional empathy (the empathic concern scale of the IRI) was evident, with individuals low in emotional empathy showing greater improvement after oxytocin administration compared to placebo.
    1 context sentence
    Summary · context
    Following the original design of Domes et al. (2007), the aim of the current study was to replicate and extend previous findings by thoroughly investigating the impact of oxytocin administration on RMET performance.

AI wrote and checked these results. AI can make mistakes, so check important results against the source.

Version history

PepBank keeps every version of the data on this study. Status changes from Retraction Watch, Europe PMC and Crossref are listed with their source.

  1. Version 2Current

    11 Oct 2026, 01:30 UTC

    Study results updated

  2. Version 1

    9 Oct 2026, 02:49 UTC

    First added · source update from Europe PMC

Subjects

Terms as the source lists them.

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