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Study · Not a test of the peptide alone · 2015

2 results

Association of Oxytocin Receptor Gene (OXTR) rs53576 Polymorphism with Sociality: A Meta-Analysis.

Li J, Zhao Y, Li R, Broster LS, Zhou C, Yang S

PloS one29 Jun 2015Cited by 92 (Europe PMC)

PMID26121678 (opens in a new tab)PMCIDPMC4488068 (opens in a new tab)DOI10.1371/journal.pone.0131820 (opens in a new tab)PepBankPUB-26121678
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Summary

A common variant in the oxytocin receptor gene (OXTR), rs53576, has been broadly linked to socially related personality traits and behaviors. However, the pattern of published results is inconsistent. Here, we performed a meta-analysis to comprehensively evaluate the association. The literature was searched for relevant studies and effect sizes between individuals homozygous for the G allele (GG) and individuals with A allele carriers (AA/AG). Specifically, two indices of sociality were evaluated independently: i) general sociality (24 samples, n = 4955), i.e., how an individual responds to other people in general; and ii) close relationships (15 samples, n = 5262), i.e., how an individual responds to individuals with closed connections (parent-child or romantic relationship). We found positive association between the rs53576 polymorphism and general sociality (Cohen's d = 0.11, p = .02); G allele homozygotes had higher general sociality than the A allele carriers. However, the meta-analyses did not detect significant genetic association between rs53576 and close relationships (Cohen's d = 0.01, p = .64). In conclusion, genetic variation in the rs53576 influences general sociality, which further implies that it is worthy to systematically examine whether the rs53576 is a valid genetic marker for socially related psychiatric disorders.
CC BYText from Europe PMC. Highlighted sentences are the source of results.

Results from this study2

No result from this study comes from a test of the peptide.

Studies that did not test the peptide alone2

In this study, Oxytocin was a lab tool or a carrier, part of a mix, or the subject of a lab method. These results are not evidence about taking Oxytocin.

  1. 01HumanNot a test of Oxytocin aloneSystematic reviewOther

    In a meta-analysis, OXTR rs53576 showed no significant genetic association with close relationships.

    In plain wordsAn oxytocin receptor gene variant was not significantly linked to how people respond in close relationships.

    Peptide
    Oxytocin
    Outcome
    No significant changeOXTR rs53576 and close relationships
    Study

    n = 5,262

    Comparator
    A allele carriers (AA/AG)
    Outcome group
    Genetic association · Nervous system and cognition

    Measurements

    Cohen's d
    0.01 d
    close relationships

    Source sentences

    Summary
    However, the meta-analyses did not detect significant genetic association between rs53576 and close relationships (Cohen's d = 0.01, p = .64).
    1 context sentence
    Summary · context
    Specifically, two indices of sociality were evaluated independently: i) general sociality (24 samples, n = 4955), i.e., how an individual responds to other people in general; and ii) close relationships (15 samples, n = 5262), i.e., how an individual responds to individuals with closed connections (parent-child or romantic relationship).

    In this study, Oxytocin was a lab tool or a carrier, part of a mix, or the subject of a lab method. This result is not evidence about taking Oxytocin.

  2. 02HumanNot a test of Oxytocin aloneSystematic reviewOther

    In a meta-analysis, G allele homozygotes of OXTR rs53576 had higher general sociality than A allele carriers.

    In plain wordsPeople with two G copies of an oxytocin receptor gene variant scored slightly higher on general sociality than A allele carriers.

    Peptide
    Oxytocin
    Outcome
    IncreaseOXTR rs53576 and general sociality
    Study

    n = 4,955

    Comparator
    A allele carriers (AA/AG)
    Outcome group
    Genetic association · Nervous system and cognition

    Measurements

    Cohen's d
    0.11 d
    general sociality

    Source sentences

    Summary
    We found positive association between the rs53576 polymorphism and general sociality (Cohen's d = 0.11, p = .02); G allele homozygotes had higher general sociality than the A allele carriers.
    1 context sentence
    Summary · context
    Specifically, two indices of sociality were evaluated independently: i) general sociality (24 samples, n = 4955), i.e., how an individual responds to other people in general; and ii) close relationships (15 samples, n = 5262), i.e., how an individual responds to individuals with closed connections (parent-child or romantic relationship).

    In this study, Oxytocin was a lab tool or a carrier, part of a mix, or the subject of a lab method. This result is not evidence about taking Oxytocin.

AI wrote and checked these results. AI can make mistakes, so check important results against the source.

Version history

PepBank keeps every version of the data on this study. Status changes from Retraction Watch, Europe PMC and Crossref are listed with their source.

  1. Version 2Current

    9 Oct 2026, 18:17 UTC

    Study results updated

  2. Version 1

    9 Oct 2026, 02:50 UTC

    First added · source update from Europe PMC

Subjects

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