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Study · Not a test of the peptide alone · 2015

2 results

[Pharmacokinetic and pharmacodynamic synergism between neuropeptides and lithium in the neurotrophic and neuroprotective action of cerebrolysin].

Gromova OA, Torshin IY, Gogoleva IV, Pronin AV, Stelmashuk EV, Isaev NK, Genrikhs EE, Demidov VI, Volkov AY, Khaspekov GL, Alexandrova OP

Zhurnal nevrologii i psikhiatrii imeni S.S. Korsakova1 Jan 2015Cited by 6 (Europe PMC)

PMID26120985 (opens in a new tab)DOI10.17116/jnevro20151153165-72 (opens in a new tab)PepBankPUB-26120985
Publisher pagePubMedAsk about this study
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Summary

The text of this summary is not shown here, because the article license does not allow reuse. Read it at the source (opens in a new tab)

Text rights: Publisher copyright. Results still quote short attributed sentences.

Results from this study2

No result from this study comes from a test of the peptide.

Studies that did not test the peptide alone2

In this study, Cerebrolysin was a lab tool or a carrier, part of a mix, or the subject of a lab method. These results are not evidence about taking Cerebrolysin.

  1. 01AnimalNot a test of Cerebrolysin aloneAnimal study (in vivo)Mechanism

    In the experimental studies, synergism between Cerebrolysin neuropeptides and lithium promoted lithium accumulation in brain tissues.

    In plain wordsIn experimental studies, Cerebrolysin neuropeptides and lithium acted together to promote lithium accumulation in brain tissues.

    Peptide
    Cerebrolysin
    Outcome
    IncreaseLithium accumulation in brain tissues
    Study

    ratn: not reported in source

    Outcome group
    Pharmacokinetics · Nervous system and cognition

    Source sentences

    Summary
    Pharmacokinetic synergism promotes the accumulation of lithium in brain tissues during cerebrolysin treatment.
    2 context sentences
    Summary · context
    A complex of experimental studies revealed that the effect of cerebrolysin is influenced by the synergism between lithium ions and the neuropeptide contentof this drug.
    Summary · context
    An experimental model of stroke (chronic bilateral occlusion of the common carotid arteries in rats), neuronal culture studies, histomorphological analyses, determination of micronutrient profile of brain substrates were used.

    In this study, Cerebrolysin was a lab tool or a carrier, part of a mix, or the subject of a lab method. This result is not evidence about taking Cerebrolysin.

  2. 02AnimalNot a test of Cerebrolysin aloneAnimal study (in vivo)Efficacy outcome

    In rats with experimental stroke, lithium ions potentiated the neuroprotective effects of Cerebrolysin.

    In plain wordsIn rats with experimental stroke, lithium increased Cerebrolysin's neuroprotective effects compared with Cerebrolysin without lithium.

    Peptide
    Cerebrolysin
    Outcome
    IncreaseNeuroprotection with lithium
    Study

    ratn: not reported in source

    Chronic bilateral occlusion of the common carotid arteries
    Comparator
    Cerebrolysin without lithium ions
    Outcome group
    Neuroprotection · Nervous system and cognition

    Source sentences

    Summary
    The existence of the pharmacokinetic synergism is evident from the potentiation of neuroprotective effects of the drug under the action of lithium ions established in the model of stroke.
    1 context sentence
    Summary · context
    An experimental model of stroke (chronic bilateral occlusion of the common carotid arteries in rats), neuronal culture studies, histomorphological analyses, determination of micronutrient profile of brain substrates were used.

    In this study, Cerebrolysin was a lab tool or a carrier, part of a mix, or the subject of a lab method. This result is not evidence about taking Cerebrolysin.

AI wrote and checked these results. AI can make mistakes, so check important results against the source.

Version history

PepBank keeps every version of the data on this study. Status changes from Retraction Watch, Europe PMC and Crossref are listed with their source.

  1. Version 2Current

    14 Oct 2026, 05:02 UTC

    Study results updated

  2. Version 1

    14 Oct 2026, 01:46 UTC

    First added · source update from Europe PMC

Subjects

Terms as the source lists them.

Publication types

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