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Study · In vitro (cells) · 2015

2 results

Thymosin α1 modifies podosome architecture and promptly stimulates the expression of podosomal markers in mature macrophages.

Serafino A, Andreola F, Pittaluga E, Krasnowska EK, Nicotera G, Sferrazza G, Sinibaldi Vallebona P, Pierimarchi P, Garaci E

Expert opinion on biological therapy22 Jun 2015Cited by 3 (Europe PMC)

PMID26098689 (opens in a new tab)DOI10.1517/14712598.2015.1024221 (opens in a new tab)PepBankPUB-26098689
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Summary

The text of this summary is not shown here, because the article license does not allow reuse. Read it at the source (opens in a new tab)

Text rights: Publisher copyright. Results still quote short attributed sentences.

Results from this study2

2 results from studies that gave the peptide. No result from this study comes from people.

  1. 01LabIn vitro (cells)Mechanism

    In human monocyte-derived macrophages in culture, thymosin alpha‑1 promptly stimulated assembly and disassembly of podosomes, which could affect macrophage motility, invasion and chemotaxis.

    In plain wordsIn lab tests, thymosin alpha‑1 quickly changed how human immune cells build and take apart podosomes, structures linked to cell movement.

    Peptide
    Thymosin alpha-1
    Outcome
    IncreasePodosome assembly and disassembly; MDM motility, invasion and chemotaxis
    Study

    humann: not reported in source

    Human monocyte-derived macrophages (MDMs)
    Outcome group
    Immune response · Immune and inflammation
    Studied dose
    Dose not stated

    Source sentences

    Summary
    We obtained data to support that Tα1 could affect MDM motility, invasion and chemotaxis by promptly stimulating assembly and disassembly of podosomal structures.
    1 context sentence
    Summary · context
    optical and scanning electron microscopy for analyzing morphology of human monocyte-derived macrophages (MDMs); time-lapse imaging for visualizing the time-dependent modifications induced at early times by Tα1 treatment; confocal microscopy and Western blot for analyzing localization and expression…
  2. 02LabIn vitro (cells)Mechanism

    Within 1 h of addition to culture medium, thymosin alpha‑1 changed macrophage morphology and podosomal components in a way that suggests increased podosome turnover.

    In plain wordsIn lab tests, thymosin alpha‑1 changed the shape of human immune cells within one hour, a sign of faster podosome turnover.

    Peptide
    Thymosin alpha-1
    Outcome
    IncreaseMDM morphology and podosomal components within 1 h
    Study

    humann: not reported in source

    Human monocyte-derived macrophages (MDMs)
    Outcome group
    Immune response · Immune and inflammation
    Studied dose
    Dose not stated

    Source sentences

    Summary
    At very early times after its addition to cell culture medium and within 1 h of treatment, Tα1 induces modifications in MDM morphology and in podosomal components that are suggestive of increased podosome turnover.
    1 context sentence
    Summary · context
    optical and scanning electron microscopy for analyzing morphology of human monocyte-derived macrophages (MDMs); time-lapse imaging for visualizing the time-dependent modifications induced at early times by Tα1 treatment; confocal microscopy and Western blot for analyzing localization and expression…

AI wrote and checked these results. AI can make mistakes, so check important results against the source.

Version history

PepBank keeps every version of the data on this study. Status changes from Retraction Watch, Europe PMC and Crossref are listed with their source.

  1. Version 3Current

    10 Oct 2026, 08:55 UTC

    Study results updated

  2. Version 2

    9 Oct 2026, 03:03 UTC

    Study data updated · source update from Europe PMC

  3. Version 1

    9 Oct 2026, 03:02 UTC

    First added · source update from Europe PMC

Subjects

Terms as the source lists them.

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