Dipeptides Increase Functional Activity of Human Skin Fibroblasts.

Malinin VV, Durnova AO, Polyakova VO, Kvetnoi IM

Bulletin of experimental biology and medicine1 May 2015Cited by 1 (Europe PMC)

PMID26033609DOI10.1007/s10517-015-2914-9PepBankPUB-26033609

Publisher page PubMedAsk about this study

Summary

The text of this summary is not shown here, because the article license does not allow reuse. Read it at the source (opens in a new tab)

Text rights: Publisher copyright. Results still quote short attributed sentences.

Results from this study6

1 result from studies that gave the peptide. No result from this study comes from people.

01LabIn vitro (cells)Mechanism
In human skin fibroblasts, Glu-Trp stimulated functional activity with an effect equivalent to Actovegin.
In plain wordsIn cells, Glu-Trp stimulated skin fibroblast activity with an effect equivalent to Actovegin.
Peptide
Thymogen (oglufanide)
Outcome
No significant changeFunctional stimulation
Study
humann: not reported in source
skin fibroblasts
Comparator
Actovegin
Outcome group
Skin and hair · Skin and wound
Studied dose
0.2, 2 and 20 μg/mlAs given in this study (human).
Source sentences
Summary
Dipeptides, especially Glu-Trp, produce a stimulating effect on human skin fibroblasts and their effect is equivalent to that of Actovegin.
1 context sentence(design, population, supporting numbers)
Summary · context
We analyzed the effect of dipeptide Glu-Trp and isovaleroyl-Glu-Trp in concentrations of 0.2, 2 and 20 μg/ml and Actovegin preparation on functional activity of human skin fibroblasts.
Report a problemFND-2603360901

Studies that did not test the peptide alone5

In this study, Thymogen (oglufanide) was a lab tool or a carrier, part of a mix, or the subject of a lab method. These results are not evidence about taking Thymogen (oglufanide).

02LabNot a test of Thymogen (oglufanide) aloneIn vitro (cells)Mechanism
In human skin fibroblasts, Glu-Trp dipeptides increased Ki-67 synthesis.
In plain wordsIn cells, the tested Glu-Trp dipeptides increased Ki-67 production.
Peptide
Thymogen (oglufanide)
Outcome
IncreaseKi-67 synthesis
Study
humann: not reported in source
skin fibroblasts
Outcome group
Skin and hair · Skin and wound
Source sentences
Summary
Dipeptides stimulate cell renewal processes by activating synthesis of Ki-67 and reducing expression of caspase-9 and enhance antioxidant function of the cells by stimulating the expression of Hsp-90 and inducible NO-synthase.
1 context sentence(design, population, supporting numbers)
Summary · context
We analyzed the effect of dipeptide Glu-Trp and isovaleroyl-Glu-Trp in concentrations of 0.2, 2 and 20 μg/ml and Actovegin preparation on functional activity of human skin fibroblasts.
In this study, Thymogen (oglufanide) was a lab tool or a carrier, part of a mix, or the subject of a lab method. This result is not evidence about taking Thymogen (oglufanide).
Report a problemFND-2603360902
03LabNot a test of Thymogen (oglufanide) aloneIn vitro (cells)Mechanism
In human skin fibroblasts, Glu-Trp dipeptides reduced caspase-9 expression.
In plain wordsIn cells, the tested Glu-Trp dipeptides reduced caspase-9 expression.
Peptide
Thymogen (oglufanide)
Outcome
DecreaseCaspase-9 expression
Study
humann: not reported in source
skin fibroblasts
Outcome group
Skin and hair · Skin and wound
Source sentences
Summary
Dipeptides stimulate cell renewal processes by activating synthesis of Ki-67 and reducing expression of caspase-9 and enhance antioxidant function of the cells by stimulating the expression of Hsp-90 and inducible NO-synthase.
1 context sentence(design, population, supporting numbers)
Summary · context
We analyzed the effect of dipeptide Glu-Trp and isovaleroyl-Glu-Trp in concentrations of 0.2, 2 and 20 μg/ml and Actovegin preparation on functional activity of human skin fibroblasts.
In this study, Thymogen (oglufanide) was a lab tool or a carrier, part of a mix, or the subject of a lab method. This result is not evidence about taking Thymogen (oglufanide).
Report a problemFND-2603360903
04LabNot a test of Thymogen (oglufanide) aloneIn vitro (cells)Mechanism
In human skin fibroblasts, Glu-Trp dipeptides increased Hsp-90 expression.
In plain wordsIn cells, the tested Glu-Trp dipeptides increased Hsp-90 expression.
Peptide
Thymogen (oglufanide)
Outcome
IncreaseHsp-90 expression
Study
humann: not reported in source
skin fibroblasts
Outcome group
Skin and hair · Skin and wound
Source sentences
Summary
Dipeptides stimulate cell renewal processes by activating synthesis of Ki-67 and reducing expression of caspase-9 and enhance antioxidant function of the cells by stimulating the expression of Hsp-90 and inducible NO-synthase.
1 context sentence(design, population, supporting numbers)
Summary · context
We analyzed the effect of dipeptide Glu-Trp and isovaleroyl-Glu-Trp in concentrations of 0.2, 2 and 20 μg/ml and Actovegin preparation on functional activity of human skin fibroblasts.
In this study, Thymogen (oglufanide) was a lab tool or a carrier, part of a mix, or the subject of a lab method. This result is not evidence about taking Thymogen (oglufanide).
Report a problemFND-2603360904
05LabNot a test of Thymogen (oglufanide) aloneIn vitro (cells)Mechanism
In human skin fibroblasts, Glu-Trp dipeptides increased inducible NO-synthase expression.
In plain wordsIn cells, the tested Glu-Trp dipeptides increased inducible NO-synthase expression.
Peptide
Thymogen (oglufanide)
Outcome
IncreaseInducible NO-synthase expression
Study
humann: not reported in source
skin fibroblasts
Outcome group
Skin and hair · Skin and wound
Source sentences
Summary
Dipeptides stimulate cell renewal processes by activating synthesis of Ki-67 and reducing expression of caspase-9 and enhance antioxidant function of the cells by stimulating the expression of Hsp-90 and inducible NO-synthase.
1 context sentence(design, population, supporting numbers)
Summary · context
We analyzed the effect of dipeptide Glu-Trp and isovaleroyl-Glu-Trp in concentrations of 0.2, 2 and 20 μg/ml and Actovegin preparation on functional activity of human skin fibroblasts.
In this study, Thymogen (oglufanide) was a lab tool or a carrier, part of a mix, or the subject of a lab method. This result is not evidence about taking Thymogen (oglufanide).
Report a problemFND-2603360905
06LabNot a test of Thymogen (oglufanide) aloneIn vitro (cells)Mechanism
In human skin fibroblasts, Glu-Trp dipeptides enhanced antioxidant function.
In plain wordsIn cells, the tested Glu-Trp dipeptides enhanced antioxidant function.
Peptide
Thymogen (oglufanide)
Outcome
IncreaseAntioxidant function
Study
humann: not reported in source
skin fibroblasts
Outcome group
Skin and hair · Skin and wound
Source sentences
Summary
Dipeptides stimulate cell renewal processes by activating synthesis of Ki-67 and reducing expression of caspase-9 and enhance antioxidant function of the cells by stimulating the expression of Hsp-90 and inducible NO-synthase.
1 context sentence(design, population, supporting numbers)
Summary · context
We analyzed the effect of dipeptide Glu-Trp and isovaleroyl-Glu-Trp in concentrations of 0.2, 2 and 20 μg/ml and Actovegin preparation on functional activity of human skin fibroblasts.
In this study, Thymogen (oglufanide) was a lab tool or a carrier, part of a mix, or the subject of a lab method. This result is not evidence about taking Thymogen (oglufanide).
Report a problemFND-2603360906

AI wrote and checked these results. AI can make mistakes, so check important results against the source.

Version history

PepBank keeps every version of the data on this study. Status changes from Retraction Watch, Europe PMC and Crossref are listed with their source.

Version 2Current
21 Oct 2026, 15:58 UTC
Study results updated
Version 1
21 Oct 2026, 12:50 UTC
First added · source update from Europe PMC

Subjects

Terms as the source lists them.

Publication types

Journal Article

MeSH terms

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