Skip to content

Study · Randomized controlled trial · n = 63 · 2015

3 results

Is it me or is it you? Behavioral and electrophysiological effects of oxytocin administration on self-other integration during joint task performance.

Ruissen MI, de Bruijn ER

Cortex; a journal devoted to the study of the nervous system and behavior8 May 2015Cited by 27 (Europe PMC)

PMID26026705 (opens in a new tab)DOI10.1016/j.cortex.2015.04.017 (opens in a new tab)PepBankPUB-26026705
Publisher pagePubMedAsk about this study
Jump to 3 results

Summary

The text of this summary is not shown here, because the article license does not allow reuse. Read it at the source (opens in a new tab)

Text rights: Publisher copyright. Results still quote short attributed sentences.

Results from this study3

3 results from studies that gave the peptide. 3 results from people.

  1. 01HumanRandomized controlled trialEfficacy outcome

    In healthy men doing a joint social Simon task, intranasal oxytocin enhanced the Simon effect in the social context compared with placebo.

    In plain wordsIn healthy men, oxytocin made the Simon effect (a measure of mixing up self and other) stronger in the social setting than placebo did.

    Peptide
    Oxytocin
    Outcome
    IncreaseSimon effect in the social context
    Study

    n = 63

    Comparator
    Placebo
    Outcome group
    Cognition and memory · Nervous system and cognition
    Studied dose
    24 IU · intranasalAs given in this study (human).

    Source sentences

    Summary
    The behavioral results demonstrated an enhanced Simon effect in the social context after oxytocin administration.
    1 context sentence
    Summary · context
    Behavioral and EEG measures were obtained from 63 healthy male volunteers who either received 24 intranasal units (IU) oxytocin or a placebo while they performed the social Simon task in an individual and a joint/social context.
  2. 02HumanRandomized controlled trialMechanism

    In healthy men, the N2 component was larger in the social than the individual context for Go trials, but only after oxytocin.

    In plain wordsIn healthy men, a brain signal of response conflict was larger in the social setting than alone, but only after oxytocin.

    Peptide
    Oxytocin
    Outcome
    IncreaseStimulus-locked N2 component (response conflict), social versus individual context
    Study

    n = 63

    Comparator
    Placebo
    Outcome group
    Brain and neuronal activity · Nervous system and cognition
    Studied dose
    24 IU · intranasalAs given in this study (human).

    Source sentences

    Summary
    At the electrophysiological level, the stimulus-locked N2 component, reflecting response conflict, was increased in the social compared to the individual context for Go trials, but only after oxytocin administration.
    1 context sentence
    Summary · context
    Behavioral and EEG measures were obtained from 63 healthy male volunteers who either received 24 intranasal units (IU) oxytocin or a placebo while they performed the social Simon task in an individual and a joint/social context.
  3. 03HumanRandomized controlled trialMechanism

    In healthy men, the P3 component was larger in the social than the individual context irrespective of condition, so oxytocin did not change it.

    In plain wordsIn healthy men, a brain signal of response inhibition was larger in the social setting regardless of oxytocin, so oxytocin did not change it.

    Peptide
    Oxytocin
    Outcome
    No significant changeP3 component (response inhibition), social versus individual context
    Study

    n = 63

    Comparator
    Placebo
    Outcome group
    Brain and neuronal activity · Nervous system and cognition
    Studied dose
    24 IU · intranasalAs given in this study (human).

    Source sentences

    Summary
    The P3 component, reflecting response inhibition, was increased for social compared to individual contexts, irrespective of condition.
    1 context sentence
    Summary · context
    Behavioral and EEG measures were obtained from 63 healthy male volunteers who either received 24 intranasal units (IU) oxytocin or a placebo while they performed the social Simon task in an individual and a joint/social context.

AI wrote and checked these results. AI can make mistakes, so check important results against the source.

Version history

PepBank keeps every version of the data on this study. Status changes from Retraction Watch, Europe PMC and Crossref are listed with their source.

  1. Version 2Current

    11 Oct 2026, 01:30 UTC

    Study results updated

  2. Version 1

    9 Oct 2026, 02:49 UTC

    First added · source update from Europe PMC

Subjects

Terms as the source lists them.

PepBank is a research reference. Talk to a doctor before you use any peptide.