[The effect of peptide ACTH4-7-PGP on functional hepatocyte state in rats in acute and chronic foot-shock stress].

Bobyntsev II, Shepeleva OM, Kryukov AA, Ivanov AV, Belykh AE

Rossiiskii fiziologicheskii zhurnal imeni I.M. Sechenova1 Feb 2015

PMID26012109PepBankPUB-26012109

Summary

The text of this summary is not shown here, because the article license does not allow reuse. Read it at the source (opens in a new tab)

Text rights: Publisher copyright. Results still quote short attributed sentences.

Results from this study9

9 results from studies that gave the peptide. No result from this study comes from people.

01AnimalAnimal study (in vivo)Efficacy outcome
In rats under acute foot-shock stress, Semax at 50 and 450 μg/kg normalized the stress-induced rise of malondialdehyde (MDA) in liver homogenate.
In plain wordsIn rats under acute stress, Semax at two doses brought a stress-raised liver marker of oxidative damage back to normal.
Peptide
Semax
Outcome
DecreaseLiver MDA level in acute foot-shock stress
Study
ratn: not reported in source
Wistar male rats, acute and chronic electrical foot-shock stress
Outcome group
Oxidative stress · Liver
Studied dose
50 and 450 μg/kg · intraperitonealAs given in this study (rat).
Source sentences
Summary
It was observed that peptide at the doses of 50 and 450 μg/kg normalized malondialdehyde (MDA) level elevation in the liver homogenate caused by acute foot-shock stress.
1 context sentence(design, population, supporting numbers)
Summary · context
The effect of ACTH4-7-PGP (Semax) intraperitoneal injection at the doses of 5, 50, 150 and 450 μg/kg b. w. on lipid peroxidation and functional hepatocytes state in Wistar male rats subjected to acute and chronic electrical foot-shock stress was investigated.
Report a problemFND-2601210901
02AnimalAnimal study (in vivo)Efficacy outcome
In rats under foot-shock stress, Semax at 5 and 150 μg/kg significantly increased liver MDA content.
In plain wordsIn rats under stress, Semax at two other doses raised a liver marker of oxidative damage.
Peptide
Semax
Outcome
IncreaseLiver MDA level at 5 and 150 μg/kg
Study
ratn: not reported in source
Wistar male rats, acute and chronic electrical foot-shock stress
Outcome group
Oxidative stress · Liver
Studied dose
5 and 150 μg/kg · intraperitonealAs given in this study (rat).
Source sentences
Summary
On the contrary, at the doses of 5 and 150 μg/kg Semax significantly increased MDA content without essential changes of antioxidant defense activity (catalase, superoxide dismutase, common antioxidative activity).
1 context sentence(design, population, supporting numbers)
Summary · context
The effect of ACTH4-7-PGP (Semax) intraperitoneal injection at the doses of 5, 50, 150 and 450 μg/kg b. w. on lipid peroxidation and functional hepatocytes state in Wistar male rats subjected to acute and chronic electrical foot-shock stress was investigated.
Report a problemFND-2601210902
03AnimalAnimal study (in vivo)Efficacy outcome
In rats under foot-shock stress, Semax at 5 and 150 μg/kg did not essentially change liver catalase activity.
In plain wordsIn rats under stress, Semax at 5 and 150 μg/kg did not clearly change liver catalase activity.
Peptide
Semax
Outcome
No significant changeLiver catalase activity
Study
ratn: not reported in source
Wistar male rats, acute and chronic electrical foot-shock stress
Outcome group
Oxidative stress · Liver
Studied dose
5 and 150 μg/kg · intraperitonealAs given in this study (rat).
Source sentences
Summary
On the contrary, at the doses of 5 and 150 μg/kg Semax significantly increased MDA content without essential changes of antioxidant defense activity (catalase, superoxide dismutase, common antioxidative activity).
1 context sentence(design, population, supporting numbers)
Summary · context
The effect of ACTH4-7-PGP (Semax) intraperitoneal injection at the doses of 5, 50, 150 and 450 μg/kg b. w. on lipid peroxidation and functional hepatocytes state in Wistar male rats subjected to acute and chronic electrical foot-shock stress was investigated.
Report a problemFND-2601210903
04AnimalAnimal study (in vivo)Efficacy outcome
In rats under foot-shock stress, Semax at 5 and 150 μg/kg did not essentially change liver superoxide dismutase activity.
In plain wordsIn rats under stress, Semax at 5 and 150 μg/kg did not clearly change liver superoxide dismutase activity.
Peptide
Semax
Outcome
No significant changeLiver superoxide dismutase activity
Study
ratn: not reported in source
Wistar male rats, acute and chronic electrical foot-shock stress
Outcome group
Oxidative stress · Liver
Studied dose
5 and 150 μg/kg · intraperitonealAs given in this study (rat).
Source sentences
Summary
On the contrary, at the doses of 5 and 150 μg/kg Semax significantly increased MDA content without essential changes of antioxidant defense activity (catalase, superoxide dismutase, common antioxidative activity).
1 context sentence(design, population, supporting numbers)
Summary · context
The effect of ACTH4-7-PGP (Semax) intraperitoneal injection at the doses of 5, 50, 150 and 450 μg/kg b. w. on lipid peroxidation and functional hepatocytes state in Wistar male rats subjected to acute and chronic electrical foot-shock stress was investigated.
Report a problemFND-2601210904
05AnimalAnimal study (in vivo)Efficacy outcome
In rats under foot-shock stress, Semax at 5 and 150 μg/kg did not essentially change common antioxidative activity in the liver.
In plain wordsIn rats under stress, Semax at 5 and 150 μg/kg did not clearly change overall liver antioxidant activity.
Peptide
Semax
Outcome
No significant changeLiver common antioxidative activity
Study
ratn: not reported in source
Wistar male rats, acute and chronic electrical foot-shock stress
Outcome group
Oxidative stress · Liver
Studied dose
5 and 150 μg/kg · intraperitonealAs given in this study (rat).
Source sentences
Summary
On the contrary, at the doses of 5 and 150 μg/kg Semax significantly increased MDA content without essential changes of antioxidant defense activity (catalase, superoxide dismutase, common antioxidative activity).
1 context sentence(design, population, supporting numbers)
Summary · context
The effect of ACTH4-7-PGP (Semax) intraperitoneal injection at the doses of 5, 50, 150 and 450 μg/kg b. w. on lipid peroxidation and functional hepatocytes state in Wistar male rats subjected to acute and chronic electrical foot-shock stress was investigated.
Report a problemFND-2601210905
06AnimalAnimal study (in vivo)Efficacy outcome
In rats under foot-shock stress, Semax at all doses decreased the stress-induced rise of serum aspartate aminotransferase (AST) activity.
In plain wordsIn rats under stress, Semax at all doses lowered a stress-raised blood liver enzyme, AST.
Peptide
Semax
Outcome
DecreaseSerum AST activity in stress
Study
ratn: not reported in source
Wistar male rats, acute and chronic electrical foot-shock stress
Outcome group
Liver fat and liver function · Liver
Studied dose
5, 50, 150 and 450 μg/kg · intraperitonealAs given in this study (rat).
Source sentences
Summary
In serum peptide at the all doses decreased stress-induced asparate aminotransferase activity elevation.
1 context sentence(design, population, supporting numbers)
Summary · context
The effect of ACTH4-7-PGP (Semax) intraperitoneal injection at the doses of 5, 50, 150 and 450 μg/kg b. w. on lipid peroxidation and functional hepatocytes state in Wistar male rats subjected to acute and chronic electrical foot-shock stress was investigated.
Report a problemFND-2601210906
07AnimalAnimal study (in vivo)Efficacy outcome
In rats under chronic foot-shock stress, Semax normalized the protein synthetic function of hepatocytes.
In plain wordsIn rats under long-term stress, Semax brought the liver cells' protein-making function back to normal.
Peptide
Semax
Outcome
Direction not reportedHepatocyte protein synthetic function in chronic stress
Study
ratn: not reported in source
Wistar male rats, acute and chronic electrical foot-shock stress
Outcome group
Liver fat and liver function · Liver
Studied dose
5, 50, 150 and 450 μg/kg · intraperitonealAs given in this study (rat).
Source sentences
Summary
In chronic stress peptide provided the normalization of protein synthetic hepatocytes function and the serum alanine aminotransferase activity with less effect on lipid peroxidation.
1 context sentence(design, population, supporting numbers)
Summary · context
The effect of ACTH4-7-PGP (Semax) intraperitoneal injection at the doses of 5, 50, 150 and 450 μg/kg b. w. on lipid peroxidation and functional hepatocytes state in Wistar male rats subjected to acute and chronic electrical foot-shock stress was investigated.
Report a problemFND-2601210907
08AnimalAnimal study (in vivo)Efficacy outcome
In rats under chronic foot-shock stress, Semax normalized serum alanine aminotransferase (ALT) activity.
In plain wordsIn rats under long-term stress, Semax brought a blood liver enzyme, ALT, back to normal.
Peptide
Semax
Outcome
Direction not reportedSerum ALT activity in chronic stress
Study
ratn: not reported in source
Wistar male rats, acute and chronic electrical foot-shock stress
Outcome group
Liver fat and liver function · Liver
Studied dose
5, 50, 150 and 450 μg/kg · intraperitonealAs given in this study (rat).
Source sentences
Summary
In chronic stress peptide provided the normalization of protein synthetic hepatocytes function and the serum alanine aminotransferase activity with less effect on lipid peroxidation.
1 context sentence(design, population, supporting numbers)
Summary · context
The effect of ACTH4-7-PGP (Semax) intraperitoneal injection at the doses of 5, 50, 150 and 450 μg/kg b. w. on lipid peroxidation and functional hepatocytes state in Wistar male rats subjected to acute and chronic electrical foot-shock stress was investigated.
Report a problemFND-2601210908
09AnimalAnimal study (in vivo)Efficacy outcome
In rats under chronic foot-shock stress, Semax had less effect on lipid peroxidation than on hepatocyte protein synthetic function and serum ALT.
In plain wordsIn rats under long-term stress, Semax had a smaller effect on a liver marker of oxidative damage than on other liver measures.
Peptide
Semax
Outcome
Direction not reportedLipid peroxidation in chronic stress
Study
ratn: not reported in source
Wistar male rats, acute and chronic electrical foot-shock stress
Outcome group
Oxidative stress · Liver
Studied dose
5, 50, 150 and 450 μg/kg · intraperitonealAs given in this study (rat).
Source sentences
Summary
In chronic stress peptide provided the normalization of protein synthetic hepatocytes function and the serum alanine aminotransferase activity with less effect on lipid peroxidation.
1 context sentence(design, population, supporting numbers)
Summary · context
The effect of ACTH4-7-PGP (Semax) intraperitoneal injection at the doses of 5, 50, 150 and 450 μg/kg b. w. on lipid peroxidation and functional hepatocytes state in Wistar male rats subjected to acute and chronic electrical foot-shock stress was investigated.
Report a problemFND-2601210909

AI wrote and checked these results. AI can make mistakes, so check important results against the source.

Version history

PepBank keeps every version of the data on this study. Status changes from Retraction Watch, Europe PMC and Crossref are listed with their source.

Version 2Current
12 Oct 2026, 17:28 UTC
Study results updated
Version 1
9 Oct 2026, 03:04 UTC
First added · source update from Europe PMC

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Terms as the source lists them.

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