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Study · Not a test of the peptide alone · 2015

1 result

Small heterodimer partner attenuates profibrogenic features of hepatitis C virus-infected cells.

Jung GS, Jeon JH, Choi YK, Jang SY, Park SY, Kim MK, Shin EC, Jeong WI, Lee IK, Kang YN, Park KG

Liver international : official journal of the International Association for the Study of the Liver3 Jun 2015Cited by 18 (Europe PMC)

PMID25976932 (opens in a new tab)DOI10.1111/liv.12871 (opens in a new tab)PepBankPUB-25976932
Publisher pagePubMedAsk about this study
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Summary

The text of this summary is not shown here, because the article license does not allow reuse. Read it at the source (opens in a new tab)

Text rights: Publisher copyright. Results still quote short attributed sentences.

Results from this study1

No result from this study comes from a test of the peptide.

Studies that did not test the peptide alone1

In this study, AICAR (acadesine) was a lab tool or a carrier, part of a mix, or the subject of a lab method. These results are not evidence about taking AICAR (acadesine).

  1. 01LabNot a test of AICAR (acadesine) aloneIn vitro (cells)Mechanism

    In HCV-infected cells, pharmacological AMPK activation with agents including AICAR restored SHP expression.

    In plain wordsIn cells infected with hepatitis C, AMPK activation with drugs including AICAR restored SHP expression.

    Peptide
    AICAR (acadesine)
    Outcome
    IncreaseSHP expression
    Study

    humann: not reported in source

    HCV-infected Huh-7.5 cells
    Outcome group
    Receptor activity and mechanism · Liver

    Source sentences

    Summary
    Pharmacological AMPK activation recovered SHP expression
    1 context sentence
    Summary · context
    The effect of adenovirus-mediated overexpression of SHP (Ad-SHP) and AMPK activation via metformin and 5-amino-1-b-D-ribofuranosyl-imidazole-4-carboxamide (AICAR) on fibrotic gene expression was evaluated in HCV-infected cells.

    In this study, AICAR (acadesine) was a lab tool or a carrier, part of a mix, or the subject of a lab method. This result is not evidence about taking AICAR (acadesine).

AI wrote and checked these results. AI can make mistakes, so check important results against the source.

Version history

PepBank keeps every version of the data on this study. Status changes from Retraction Watch, Europe PMC and Crossref are listed with their source.

  1. Version 2Current

    21 Oct 2026, 15:58 UTC

    Study results updated

  2. Version 1

    21 Oct 2026, 12:50 UTC

    First added · source update from Europe PMC

Subjects

Terms as the source lists them.

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