In old female rhesus monkeys, Pancragen markedly increased glucose disappearance rate after glucose administration compared with the control period.
In plain wordsIn rhesus monkeys, Pancragen increased glucose disappearance after glucose administration in old females compared with the control period.
- Peptide
- Pancragen (KEDW)
- Outcome
- IncreaseGlucose disappearance rate
- Study
rhesus monkeyn: not reported in source
old female rhesus monkeys- Comparator
- control period
- Outcome group
- Glycemic control · Metabolic and weight
- Studied dose
- 50 μg/animal per day · intramuscularly · 10 daysAs given in this study (rhesus monkey).
Source sentences
Pancragen administration (50 μg/animal per day during 10 days, intramuscularly) to old monkeys caused markedly increased the glucose "disappear- ance" rate,
2 context sentences(design, population, supporting numbers)
In old animals after the glucose administration (standard dose) in control period, a reduced glucose "disappearance" rate and a higher values of insulin and C-peptide peaks (5 and 15 min after the glucose injection) were observed in comparison with young animals in similar experiments.
The purpose of this research was to study impact of Pancragen (tetrapeptide Lys-Glu-Asp-Trp) on endocrine function of the pancreas of non-human primates, female rhesus monkeys, and to elucidate the possibil- ity of its use for correction age-related dysfunction of pancreatic islet apparatus.