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Study · Randomized controlled trial · 2015

2 results

Amygdala-Hippocampal Connectivity Changes During Acute Psychosocial Stress: Joint Effect of Early Life Stress and Oxytocin.

Fan Y, Pestke K, Feeser M, Aust S, Pruessner JC, Böker H, Bajbouj M, Grimm S

Neuropsychopharmacology : official publication of the American College of Neuropsychopharmacology29 Apr 2015Cited by 66 (Europe PMC)

PMID25924202 (opens in a new tab)PMCIDPMC4864649 (opens in a new tab)DOI10.1038/npp.2015.123 (opens in a new tab)PepBankPUB-25924202
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Summary

The text of this summary is not shown here, because the article license does not allow reuse. Read it at the source (opens in a new tab)

Text rights: Publisher copyright. Results still quote short attributed sentences.

Results from this study2

2 results from studies that gave the peptide. 2 results from people.

  1. 01HumanRandomized controlled trialMechanism

    In a crossover trial of acute psychosocial stress, intranasal oxytocin moderated the positive association between emotional abuse and stress-induced amygdala-hippocampal connectivity.

    In plain wordsOxytocin changed how childhood emotional abuse was linked to brain connectivity between two brain areas during stress, compared with placebo.

    Peptide
    Oxytocin
    Outcome
    MixedAssociation of emotional abuse with stress-induced amygdala-hippocampal connectivity
    Study

    n: not reported in source

    Comparator
    Placebo
    Outcome group
    Brain and neuronal activity · Nervous system and cognition
    Studied dose
    Dose not stated · intranasalAs given in this study (human).

    Source sentences

    Summary
    Moreover, hierarchical linear regression showed that this positive association between EA and stress-induced amygdala-hippocampal connectivity was moderated after the administration of intranasal OXT.
    1 context sentence
    Summary · context
    Therefore, we here investigate the joint effect of ELS and OXT on transient changes in amygdala-centered functional connectivity induced by acute psychosocial stress, using a double-blind, randomized, placebo-controlled, within-subject crossover design.
  2. 02HumanRandomized controlled trialMechanism

    In the oxytocin session, amygdala-hippocampal connectivity correlated negatively with cortisol stress responses.

    In plain wordsAfter oxytocin, stronger connectivity between two brain areas went with a smaller stress cortisol response.

    Peptide
    Oxytocin
    Outcome
    DecreaseAmygdala-hippocampal connectivity versus cortisol stress response
    Study

    n: not reported in source

    Outcome group
    Brain and neuronal activity · Nervous system and cognition
    Studied dose
    Dose not stated · intranasalAs given in this study (human).

    Source sentences

    Summary
    Amygdala-hippocampal connectivity in the OXT session correlated negatively with cortisol stress responses.
    1 context sentence
    Summary · context
    Therefore, we here investigate the joint effect of ELS and OXT on transient changes in amygdala-centered functional connectivity induced by acute psychosocial stress, using a double-blind, randomized, placebo-controlled, within-subject crossover design.

AI wrote and checked these results. AI can make mistakes, so check important results against the source.

Version history

PepBank keeps every version of the data on this study. Status changes from Retraction Watch, Europe PMC and Crossref are listed with their source.

  1. Version 2Current

    11 Oct 2026, 01:30 UTC

    Study results updated

  2. Version 1

    9 Oct 2026, 02:50 UTC

    First added · source update from Europe PMC

Subjects

Terms as the source lists them.

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