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Study · Systematic review · 2015

1 result

Sex hormones and oxytocin augmentation strategies in schizophrenia: A quantitative review.

Heringa SM, Begemann MJ, Goverde AJ, Sommer IE, Sommer IE

Schizophrenia research23 Apr 2015Cited by 63 (Europe PMC)

PMID25914107 (opens in a new tab)DOI10.1016/j.schres.2015.04.002 (opens in a new tab)PepBankPUB-25914107
Publisher pagePubMedAsk about this study
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Summary

The text of this summary is not shown here, because the article license does not allow reuse. Read it at the source (opens in a new tab)

Text rights: Publisher copyright. Results still quote short attributed sentences.

Results from this study1

1 result from studies that gave the peptide. 1 result from people.

  1. 01HumanSystematic reviewEfficacy outcome

    In double-blind placebo-controlled studies in schizophrenia, meta-analysis found no overall effect of oxytocin augmentation (k=6).

    In plain wordsIn people with schizophrenia, adding oxytocin to treatment showed no overall effect compared with placebo in pooled studies.

    Peptide
    Oxytocin
    Outcome
    No significant changeOverall effect of oxytocin augmentation in schizophrenia
    Study

    n: not reported in source

    Comparator
    Placebo
    Outcome group
    Psychiatric symptoms · Mental health and mood
    Studied dose
    Dose not stated

    Source sentences

    Summary
    No overall effects were found for DHEA (k=4), pregnenolone (k=4), and oxytocin (k=6).
    2 context sentences
    Summary · context
    Double-blind, placebo-controlled, randomized studies were included, examining augmentation with estrogens, selective estrogen receptor modulators (SERMs), testosterone, dehydroepiandrosterone (DHEA), pregnenolone, and oxytocin.
    Summary · context
    Outcome measures were total symptom severity, positive and negative symptom subscores, and cognition.

AI wrote and checked these results. AI can make mistakes, so check important results against the source.

Version history

PepBank keeps every version of the data on this study. Status changes from Retraction Watch, Europe PMC and Crossref are listed with their source.

  1. Version 2Current

    9 Oct 2026, 18:17 UTC

    Study results updated

  2. Version 1

    9 Oct 2026, 02:49 UTC

    First added · source update from Europe PMC

Subjects

Terms as the source lists them.

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