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Study · Not a test of the peptide alone · 2015

7 results

The Use of HCG-Based Combination Therapy for Recovery of Spermatogenesis after Testosterone Use.

Wenker EP, Dupree JM, Langille GM, Kovac J, Ramasamy R, Lamb D, Mills JN, Lipshultz LI

The journal of sexual medicine22 Apr 2015Cited by 54 (Europe PMC)

PMID25904023 (opens in a new tab)DOI10.1111/jsm.12890 (opens in a new tab)PepBankPUB-25904023
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Summary

The text of this summary is not shown here, because the article license does not allow reuse. Read it at the source (opens in a new tab)

Text rights: Publisher copyright. Results still quote short attributed sentences.

Results from this study7

No result from this study comes from a test of the peptide.

Studies that did not test the peptide alone7

In this study, hCG (human chorionic gonadotropin) was a lab tool or a carrier, part of a mix, or the subject of a lab method. These results are not evidence about taking hCG (human chorionic gonadotropin).

  1. 01HumanNot a test of hCG (human chorionic gonadotropin) aloneCase report or seriesEfficacy outcome

    In men with testosterone-related infertility, hCG-based combination therapy restored spermatogenesis or improved sperm counts in 47 men (95.9%).

    In plain wordsIn men with testosterone-related infertility, hCG-based combination therapy restored sperm production or improved counts in 47 men (95.9%).

    Peptide
    hCG (human chorionic gonadotropin)
    Outcome
    IncreaseReturn or improvement of spermatogenesis
    Study

    n = 49

    Outcome group
    Sex hormones and fertility · Reproductive and sexual health

    Measurements

    Men with return of spermatogenesis or improved sperm counts
    47 men
    hCG-based combination therapy
    Return of spermatogenesis or improved sperm counts
    95.9%
    hCG-based combination therapy

    Source sentences

    Summary
    Return of spermatogenesis for azoospermic men or improved counts for men with severe oligospermia was documented in 47 men (95.9%), with one additional man (2.1%) having a documented pregnancy without follow-up semen analysis.
    3 context sentences
    Summary · context
    We retrospectively reviewed charts from two tertiary care infertility clinics to identify men presenting with azoospermia or severe oligospermia (<1 million sperm/mL) while taking exogenous testosterone.
    Summary · context
    All were noted to have been placed on combination therapy, which included 3,000 units HCG subcutaneously every other day supplemented with clomiphene citrate, tamoxifen, anastrozole, or recombinant follicle-stimulating hormone (or combination) according to physician preference.
    Summary · context
    Forty-nine men were included in this case series.

    In this study, hCG (human chorionic gonadotropin) was a lab tool or a carrier, part of a mix, or the subject of a lab method. This result is not evidence about taking hCG (human chorionic gonadotropin).

  2. 02HumanNot a test of hCG (human chorionic gonadotropin) aloneCase report or seriesEfficacy outcome

    In the hCG-based combination series, one additional man (2.1%) had a documented pregnancy without follow-up semen analysis.

    In plain wordsIn the hCG-based combination series, one additional man (2.1%) had a documented pregnancy without a later semen test.

    Peptide
    hCG (human chorionic gonadotropin)
    Outcome
    Not applicablePregnancy without follow-up semen analysis
    Study

    n = 49

    Outcome group
    Sex hormones and fertility · Reproductive and sexual health

    Measurements

    Additional men with documented pregnancy without follow-up semen analysis
    1 men
    hCG-based combination therapy
    Documented pregnancy without follow-up semen analysis
    2.1%
    Additional man, hCG-based combination therapy

    Source sentences

    Summary
    Return of spermatogenesis for azoospermic men or improved counts for men with severe oligospermia was documented in 47 men (95.9%), with one additional man (2.1%) having a documented pregnancy without follow-up semen analysis.
    3 context sentences
    Summary · context
    We retrospectively reviewed charts from two tertiary care infertility clinics to identify men presenting with azoospermia or severe oligospermia (<1 million sperm/mL) while taking exogenous testosterone.
    Summary · context
    All were noted to have been placed on combination therapy, which included 3,000 units HCG subcutaneously every other day supplemented with clomiphene citrate, tamoxifen, anastrozole, or recombinant follicle-stimulating hormone (or combination) according to physician preference.
    Summary · context
    Forty-nine men were included in this case series.

    In this study, hCG (human chorionic gonadotropin) was a lab tool or a carrier, part of a mix, or the subject of a lab method. This result is not evidence about taking hCG (human chorionic gonadotropin).

  3. 03HumanNot a test of hCG (human chorionic gonadotropin) aloneCase report or seriesSafety outcome

    In the hCG-based combination series, no men stopped hCG or supplemental medication because of adverse events.

    In plain wordsIn the hCG-based combination series, no men stopped hCG or supplemental medication because of side effects.

    Peptide
    hCG (human chorionic gonadotropin)
    Outcome
    No significant changeAdverse-event discontinuation
    Study

    n = 49

    Outcome group
    Adverse events · Whole body

    Source sentences

    Summary
    No men stopped HCG or supplemental medications because of adverse events.
    3 context sentences
    Summary · context
    We retrospectively reviewed charts from two tertiary care infertility clinics to identify men presenting with azoospermia or severe oligospermia (<1 million sperm/mL) while taking exogenous testosterone.
    Summary · context
    All were noted to have been placed on combination therapy, which included 3,000 units HCG subcutaneously every other day supplemented with clomiphene citrate, tamoxifen, anastrozole, or recombinant follicle-stimulating hormone (or combination) according to physician preference.
    Summary · context
    Forty-nine men were included in this case series.

    In this study, hCG (human chorionic gonadotropin) was a lab tool or a carrier, part of a mix, or the subject of a lab method. This result is not evidence about taking hCG (human chorionic gonadotropin).

  4. 04HumanNot a test of hCG (human chorionic gonadotropin) aloneCase report or seriesEfficacy outcome

    In men receiving hCG-based combination therapy, average time to return of spermatogenesis was 4.6 months.

    In plain wordsIn men receiving hCG-based combination therapy, sperm production returned after an average of 4.6 months.

    Peptide
    hCG (human chorionic gonadotropin)
    Outcome
    Not applicableTime to return of spermatogenesis
    Study

    n: not reported in source

    Outcome group
    Sex hormones and fertility · Reproductive and sexual health

    Measurements

    Average time to return of spermatogenesis
    4.6 months
    hCG-based combination therapy

    Source sentences

    Summary
    The average time to return of spermatogenesis was 4.6 months with a mean first density of 22.6 million/mL.
    3 context sentences
    Summary · context
    We retrospectively reviewed charts from two tertiary care infertility clinics to identify men presenting with azoospermia or severe oligospermia (<1 million sperm/mL) while taking exogenous testosterone.
    Summary · context
    All were noted to have been placed on combination therapy, which included 3,000 units HCG subcutaneously every other day supplemented with clomiphene citrate, tamoxifen, anastrozole, or recombinant follicle-stimulating hormone (or combination) according to physician preference.
    Summary · context
    Forty-nine men were included in this case series.

    In this study, hCG (human chorionic gonadotropin) was a lab tool or a carrier, part of a mix, or the subject of a lab method. This result is not evidence about taking hCG (human chorionic gonadotropin).

  5. 05HumanNot a test of hCG (human chorionic gonadotropin) aloneCase report or seriesEfficacy outcome

    In men receiving hCG-based combination therapy, mean first sperm density was 22.6 million/mL.

    In plain wordsIn men receiving hCG-based combination therapy, the first average sperm concentration was 22.6 million/mL.

    Peptide
    hCG (human chorionic gonadotropin)
    Outcome
    Not applicableFirst sperm density
    Study

    n: not reported in source

    Outcome group
    Sex hormones and fertility · Reproductive and sexual health

    Measurements

    Mean first sperm density
    22.6 million/mL
    hCG-based combination therapy

    Source sentences

    Summary
    The average time to return of spermatogenesis was 4.6 months with a mean first density of 22.6 million/mL.
    3 context sentences
    Summary · context
    We retrospectively reviewed charts from two tertiary care infertility clinics to identify men presenting with azoospermia or severe oligospermia (<1 million sperm/mL) while taking exogenous testosterone.
    Summary · context
    All were noted to have been placed on combination therapy, which included 3,000 units HCG subcutaneously every other day supplemented with clomiphene citrate, tamoxifen, anastrozole, or recombinant follicle-stimulating hormone (or combination) according to physician preference.
    Summary · context
    Forty-nine men were included in this case series.

    In this study, hCG (human chorionic gonadotropin) was a lab tool or a carrier, part of a mix, or the subject of a lab method. This result is not evidence about taking hCG (human chorionic gonadotropin).

  6. 06HumanNot a test of hCG (human chorionic gonadotropin) aloneCase report or seriesEfficacy outcome

    In men receiving hCG-based combination therapy, recovery did not significantly differ by testosterone type.

    In plain wordsIn men receiving hCG-based combination therapy, recovery did not significantly differ between testosterone types.

    Peptide
    hCG (human chorionic gonadotropin)
    Outcome
    No significant changeRecovery by testosterone type
    Study

    n: not reported in source

    Comparator
    Other testosterone types
    Outcome group
    Sex hormones and fertility · Reproductive and sexual health

    Source sentences

    Summary
    There was no significant difference in recovery by type of testosterone administered or supplemental therapy.
    3 context sentences
    Summary · context
    We retrospectively reviewed charts from two tertiary care infertility clinics to identify men presenting with azoospermia or severe oligospermia (<1 million sperm/mL) while taking exogenous testosterone.
    Summary · context
    All were noted to have been placed on combination therapy, which included 3,000 units HCG subcutaneously every other day supplemented with clomiphene citrate, tamoxifen, anastrozole, or recombinant follicle-stimulating hormone (or combination) according to physician preference.
    Summary · context
    Forty-nine men were included in this case series.

    In this study, hCG (human chorionic gonadotropin) was a lab tool or a carrier, part of a mix, or the subject of a lab method. This result is not evidence about taking hCG (human chorionic gonadotropin).

  7. 07HumanNot a test of hCG (human chorionic gonadotropin) aloneCase report or seriesEfficacy outcome

    In men receiving hCG-based combination therapy, recovery did not significantly differ by supplemental therapy.

    In plain wordsIn men receiving hCG-based combination therapy, recovery did not significantly differ between supplemental treatments.

    Peptide
    hCG (human chorionic gonadotropin)
    Outcome
    No significant changeRecovery by supplemental therapy
    Study

    n: not reported in source

    Comparator
    Other supplemental therapies
    Outcome group
    Sex hormones and fertility · Reproductive and sexual health

    Source sentences

    Summary
    There was no significant difference in recovery by type of testosterone administered or supplemental therapy.
    3 context sentences
    Summary · context
    We retrospectively reviewed charts from two tertiary care infertility clinics to identify men presenting with azoospermia or severe oligospermia (<1 million sperm/mL) while taking exogenous testosterone.
    Summary · context
    All were noted to have been placed on combination therapy, which included 3,000 units HCG subcutaneously every other day supplemented with clomiphene citrate, tamoxifen, anastrozole, or recombinant follicle-stimulating hormone (or combination) according to physician preference.
    Summary · context
    Forty-nine men were included in this case series.

    In this study, hCG (human chorionic gonadotropin) was a lab tool or a carrier, part of a mix, or the subject of a lab method. This result is not evidence about taking hCG (human chorionic gonadotropin).

AI wrote and checked these results. AI can make mistakes, so check important results against the source.

Version history

PepBank keeps every version of the data on this study. Status changes from Retraction Watch, Europe PMC and Crossref are listed with their source.

  1. Version 2Current

    14 Oct 2026, 05:02 UTC

    Study results updated

  2. Version 1

    14 Oct 2026, 01:46 UTC

    First added · source update from Europe PMC

Subjects

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