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Study · Randomized controlled trial · n = 25 · 2015

8 results

Oxytocin reduces caloric intake in men.

Lawson EA, Marengi DA, DeSanti RL, Holmes TM, Schoenfeld DA, Tolley CJ

Obesity (Silver Spring, Md.)10 Apr 2015Cited by 172 (Europe PMC)

PMID25865294 (opens in a new tab)PMCIDPMC4414748 (opens in a new tab)DOI10.1002/oby.21069 (opens in a new tab)PepBankPUB-25865294
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Summary

The text of this summary is not shown here, because the article license does not allow reuse. Read it at the source (opens in a new tab)

Text rights: Publisher copyright. Results still quote short attributed sentences.

Results from this study8

8 results from studies that gave the peptide. 8 results from people.

  1. 01HumanRandomized controlled trialEfficacy outcome

    In fasting healthy men, single-dose intranasal oxytocin reduced caloric intake versus placebo.

    In plain wordsIn healthy men, one dose of oxytocin through the nose lowered the calories eaten at breakfast, compared with placebo.

    Peptide
    Oxytocin
    Outcome
    DecreaseCaloric intake at breakfast
    Study

    n = 25

    Comparator
    Placebo
    Outcome group
    Appetite and food intake · Metabolic and weight
    Studied dose
    24 IU · intranasal · single doseAs given in this study (human).

    Source sentences

    Summary
    Oxytocin reduced caloric intake with a preferential effect on fat intake
    1 context sentence
    Summary · context
    A randomized, placebo-controlled crossover study of single-dose intranasal oxytocin (24 IU) in 25 fasting healthy men was performed.
  2. 02HumanRandomized controlled trialEfficacy outcome

    In fasting healthy men, the reduction in caloric intake after single-dose intranasal oxytocin had a preferential effect on fat intake versus placebo.

    In plain wordsIn healthy men, one dose of oxytocin through the nose cut calories eaten, with a stronger effect on fat intake, compared with placebo.

    Peptide
    Oxytocin
    Outcome
    DecreaseFat intake
    Study

    n = 25

    Comparator
    Placebo
    Outcome group
    Appetite and food intake · Metabolic and weight
    Studied dose
    24 IU · intranasal · single doseAs given in this study (human).

    Source sentences

    Summary
    Oxytocin reduced caloric intake with a preferential effect on fat intake
    1 context sentence
    Summary · context
    A randomized, placebo-controlled crossover study of single-dose intranasal oxytocin (24 IU) in 25 fasting healthy men was performed.
  3. 03HumanRandomized controlled trialEfficacy outcome

    In fasting healthy men, single-dose intranasal oxytocin increased levels of the anorexigenic hormone cholecystokinin versus placebo.

    In plain wordsIn healthy men, one dose of oxytocin through the nose raised the appetite-reducing hormone cholecystokinin, compared with placebo.

    Peptide
    Oxytocin
    Outcome
    IncreaseCholecystokinin level
    Study

    n = 25

    Comparator
    Placebo
    Outcome group
    Hormone levels · Metabolic and weight
    Studied dose
    24 IU · intranasal · single doseAs given in this study (human).

    Source sentences

    Summary
    increased levels of the anorexigenic hormone cholecystokinin
    1 context sentence
    Summary · context
    A randomized, placebo-controlled crossover study of single-dose intranasal oxytocin (24 IU) in 25 fasting healthy men was performed.
  4. 04HumanRandomized controlled trialEfficacy outcome

    In fasting healthy men, single-dose intranasal oxytocin did not affect appetite versus placebo.

    In plain wordsIn healthy men, one dose of oxytocin through the nose did not change appetite ratings, compared with placebo.

    Peptide
    Oxytocin
    Outcome
    No significant changeAppetite (visual analog scales)
    Study

    n = 25

    Comparator
    Placebo
    Outcome group
    Appetite and food intake · Metabolic and weight
    Studied dose
    24 IU · intranasal · single doseAs given in this study (human).

    Source sentences

    Summary
    without affecting appetite or other appetite-regulating hormones.
    1 context sentence
    Summary · context
    A randomized, placebo-controlled crossover study of single-dose intranasal oxytocin (24 IU) in 25 fasting healthy men was performed.
  5. 05HumanRandomized controlled trialEfficacy outcome

    In fasting healthy men, single-dose intranasal oxytocin did not affect appetite-regulating hormones other than cholecystokinin versus placebo.

    In plain wordsIn healthy men, one dose of oxytocin through the nose did not change other appetite hormones, compared with placebo.

    Peptide
    Oxytocin
    Outcome
    No significant changeOther appetite-regulating hormones
    Study

    n = 25

    Comparator
    Placebo
    Outcome group
    Hormone levels · Metabolic and weight
    Studied dose
    24 IU · intranasal · single doseAs given in this study (human).

    Source sentences

    Summary
    without affecting appetite or other appetite-regulating hormones.
    1 context sentence
    Summary · context
    A randomized, placebo-controlled crossover study of single-dose intranasal oxytocin (24 IU) in 25 fasting healthy men was performed.
  6. 06HumanRandomized controlled trialEfficacy outcome

    In fasting healthy men, single-dose intranasal oxytocin had no effect on resting energy expenditure versus placebo.

    In plain wordsIn healthy men, one dose of oxytocin through the nose did not change resting energy use, compared with placebo.

    Peptide
    Oxytocin
    Outcome
    No significant changeResting energy expenditure
    Study

    n = 25

    Comparator
    Placebo
    Outcome group
    Energy expenditure and thermogenesis · Metabolic and weight
    Studied dose
    24 IU · intranasal · single doseAs given in this study (human).

    Source sentences

    Summary
    There was no effect of oxytocin on REE.
    1 context sentence
    Summary · context
    A randomized, placebo-controlled crossover study of single-dose intranasal oxytocin (24 IU) in 25 fasting healthy men was performed.
  7. 07HumanRandomized controlled trialEfficacy outcome

    In fasting healthy men, single-dose intranasal oxytocin shifted substrate utilization from carbohydrate to fat versus placebo.

    In plain wordsIn healthy men, one dose of oxytocin through the nose shifted the body from burning carbohydrate to burning fat, compared with placebo.

    Peptide
    Oxytocin
    Outcome
    IncreaseSubstrate utilization (carbohydrate to fat)
    Study

    n = 25

    Comparator
    Placebo
    Outcome group
    Energy expenditure and thermogenesis · Metabolic and weight
    Studied dose
    24 IU · intranasal · single doseAs given in this study (human).

    Source sentences

    Summary
    Oxytocin resulted in a shift from carbohydrate to fat utilization
    1 context sentence
    Summary · context
    A randomized, placebo-controlled crossover study of single-dose intranasal oxytocin (24 IU) in 25 fasting healthy men was performed.
  8. 08HumanRandomized controlled trialEfficacy outcome

    In fasting healthy men, single-dose intranasal oxytocin improved insulin sensitivity versus placebo.

    In plain wordsIn healthy men, one dose of oxytocin through the nose improved insulin sensitivity, compared with placebo.

    Peptide
    Oxytocin
    Outcome
    IncreaseInsulin sensitivity
    Study

    n = 25

    Comparator
    Placebo
    Outcome group
    Glycemic control · Metabolic and weight
    Studied dose
    24 IU · intranasal · single doseAs given in this study (human).

    Source sentences

    Summary
    improved insulin sensitivity.
    1 context sentence
    Summary · context
    A randomized, placebo-controlled crossover study of single-dose intranasal oxytocin (24 IU) in 25 fasting healthy men was performed.

AI wrote and checked these results. AI can make mistakes, so check important results against the source.

Version history

PepBank keeps every version of the data on this study. Status changes from Retraction Watch, Europe PMC and Crossref are listed with their source.

  1. Version 2Current

    11 Oct 2026, 01:30 UTC

    Study results updated

  2. Version 1

    9 Oct 2026, 02:49 UTC

    First added · source update from Europe PMC

Subjects

Terms as the source lists them.

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