In diabetic mice, cerebrolysin reversed streptozotocin-induced hippocampal dendritic morphological changes.
In plain wordsIn diabetic mice, cerebrolysin reversed hippocampal dendritic changes induced by streptozotocin.
- Peptide
- Cerebrolysin
- Outcome
- IncreaseHippocampal dendritic morphology
- Study
micen: not reported in source
Streptozotocin-induced type 1 diabetes- Outcome group
- Neuroprotection · Nervous system and cognition
- Studied dose
- Dose not stated · 6 weeksAs given in this study (mice).
Source sentences
Interestingly, Cbl reversed the morphological changes induced by streptozotocin.
3 context sentences(design, population, supporting numbers)
In mice treated with streptozotocin there was a clear reduction in the dendritic length of pyramidal neurons of the CA1 and granular cells of the dental gyrus of the dorsal hippocampus.
This study aimed to determine whether Cbl was capable of reducing behavioral and neuronal alterations, after 6 weeks of hyperglycemia in mice (streptozotocin-induced DM1).
After streptozotocin treatment, the mice received 6 weeks of Cbl, locomotor activity was measured and dendritic morphological changes were evaluated using Golgi-Cox stain procedure, and analyzed by the Sholl method.