Glu-Trp-ONa or its acylated analogue (R-Glu-Trp-ONa) administration enhances the wound healing in the model of chronic skin wounds in rabbits.

Shevtsov MA, Smagina LV, Kudriavtceva TA, Petlenko SV, Voronkina IV

Drug design, development and therapy20 Mar 2015Cited by 3 (Europe PMC)

PMID25848208PMCIDPMC4374713DOI10.2147/dddt.s79665PepBankPUB-25848208

Read at source PubMedAsk about this study

Summary

The text of this summary is not shown here, because the article license does not allow reuse. Read it at the source (opens in a new tab)

Text rights: CC BY-NC. Results still quote short attributed sentences.

Results from this study13

2 results from studies that gave the peptide. No result from this study comes from people.

01AnimalAnimal study (in vivo)Efficacy outcome
In rabbits with nonhealing wounds, Glu-Trp-ONa shortened wound healing compared with control.
In plain wordsIn rabbits, Glu-Trp-ONa shortened wound healing compared with control.
Peptide
Thymogen (oglufanide)
Outcome
DecreaseWound healing period versus control
Study
rabbitn: not reported in source
nonhealing dermal wounds
Comparator
Phosphate-buffered saline
Outcome group
Wound healing · Skin and wound
Studied dose
Dose not stated · intraperitoneal injectionAs given in this study (rabbit).
Source sentences
Summary
An injection of Glu-Trp-ONa and R-Glu-Trp-ONa decreased the period of wound healing in animals in comparison to the control and Solcoseryl-treated groups.
2 context sentences(design, population, supporting numbers)
Summary · context
Following wound modeling, the rabbits received a course of intraperitoneal injections of Glu-Trp-ONa or R-Glu-Trp-ONa. Phosphate-buffered saline and Solcoseryl® were applied as negative and positive control agents, respectively.
Summary · context
The synthesized dipeptide (Glu-Trp-ONa) and its acylated analogue (R-Glu-Trp-ONa) were assessed in the model of nonhealing dermal wounds in rabbits in relation to their healing properties in wound closure.
Report a problemFND-2584820801
02AnimalAnimal study (in vivo)Efficacy outcome
In rabbits with nonhealing wounds, Glu-Trp-ONa shortened wound healing compared with Solcoseryl.
In plain wordsIn rabbits, Glu-Trp-ONa shortened wound healing compared with Solcoseryl.
Peptide
Thymogen (oglufanide)
Outcome
DecreaseWound healing period versus Solcoseryl
Study
rabbitn: not reported in source
nonhealing dermal wounds
Comparator
Solcoseryl
Outcome group
Wound healing · Skin and wound
Studied dose
Dose not stated · intraperitoneal injectionAs given in this study (rabbit).
Source sentences
Summary
An injection of Glu-Trp-ONa and R-Glu-Trp-ONa decreased the period of wound healing in animals in comparison to the control and Solcoseryl-treated groups.
2 context sentences(design, population, supporting numbers)
Summary · context
Following wound modeling, the rabbits received a course of intraperitoneal injections of Glu-Trp-ONa or R-Glu-Trp-ONa. Phosphate-buffered saline and Solcoseryl® were applied as negative and positive control agents, respectively.
Summary · context
The synthesized dipeptide (Glu-Trp-ONa) and its acylated analogue (R-Glu-Trp-ONa) were assessed in the model of nonhealing dermal wounds in rabbits in relation to their healing properties in wound closure.
Report a problemFND-2584820802

Studies that did not test the peptide alone11

In this study, Thymogen (oglufanide) was a lab tool or a carrier, part of a mix, or the subject of a lab method. These results are not evidence about taking Thymogen (oglufanide).

03AnimalNot a test of Thymogen (oglufanide) aloneAnimal study (in vivo)Efficacy outcome
In rabbits, acylation improved the wound-healing properties of Glu-Trp-ONa.
In plain wordsIn rabbits, the acylated Glu-Trp-ONa analogue had better healing properties than the original dipeptide.
Peptide
Thymogen (oglufanide)
Outcome
IncreaseHealing properties after acylation
Study
rabbitn: not reported in source
nonhealing dermal wounds
Comparator
Glu-Trp-ONa
Outcome group
Wound healing · Skin and wound
Source sentences
Summary
Acylation of Glu-Trp-ONa proved to be beneficial as related to the healing properties of the dipeptide.
1 context sentence(design, population, supporting numbers)
Summary · context
The synthesized dipeptide (Glu-Trp-ONa) and its acylated analogue (R-Glu-Trp-ONa) were assessed in the model of nonhealing dermal wounds in rabbits in relation to their healing properties in wound closure.
In this study, Thymogen (oglufanide) was a lab tool or a carrier, part of a mix, or the subject of a lab method. This result is not evidence about taking Thymogen (oglufanide).
Report a problemFND-2584820803
04AnimalNot a test of Thymogen (oglufanide) aloneAnimal study (in vivo)Mechanism
In rabbit wounds, Glu-Trp-ONa peptides decreased MMP-9 activity during early inflammation.
In plain wordsIn rabbits, the tested Glu-Trp-ONa peptides reduced MMP-9 activity during early wound inflammation.
Peptide
Thymogen (oglufanide)
Outcome
DecreaseEarly inflammatory MMP-9 activity
Study
rabbitn: not reported in source
nonhealing dermal wounds
Outcome group
Wound healing · Skin and wound
Source sentences
Summary
Subsequent zymography analyses showed that the applied peptides decreased the proteolytic activity of matrix metalloproteinases MMP-9, MMP-8, and MMP-2 in the early inflammatory phase and reversely increased the activity of MMP-9, MMP-8, and MMP-1 in the remodeling phase.
1 context sentence(design, population, supporting numbers)
Summary · context
The synthesized dipeptide (Glu-Trp-ONa) and its acylated analogue (R-Glu-Trp-ONa) were assessed in the model of nonhealing dermal wounds in rabbits in relation to their healing properties in wound closure.
In this study, Thymogen (oglufanide) was a lab tool or a carrier, part of a mix, or the subject of a lab method. This result is not evidence about taking Thymogen (oglufanide).
Report a problemFND-2584820804
05AnimalNot a test of Thymogen (oglufanide) aloneAnimal study (in vivo)Mechanism
In rabbit wounds, Glu-Trp-ONa peptides decreased MMP-8 activity during early inflammation.
In plain wordsIn rabbits, the tested Glu-Trp-ONa peptides reduced MMP-8 activity during early wound inflammation.
Peptide
Thymogen (oglufanide)
Outcome
DecreaseEarly inflammatory MMP-8 activity
Study
rabbitn: not reported in source
nonhealing dermal wounds
Outcome group
Wound healing · Skin and wound
Source sentences
Summary
Subsequent zymography analyses showed that the applied peptides decreased the proteolytic activity of matrix metalloproteinases MMP-9, MMP-8, and MMP-2 in the early inflammatory phase and reversely increased the activity of MMP-9, MMP-8, and MMP-1 in the remodeling phase.
1 context sentence(design, population, supporting numbers)
Summary · context
The synthesized dipeptide (Glu-Trp-ONa) and its acylated analogue (R-Glu-Trp-ONa) were assessed in the model of nonhealing dermal wounds in rabbits in relation to their healing properties in wound closure.
In this study, Thymogen (oglufanide) was a lab tool or a carrier, part of a mix, or the subject of a lab method. This result is not evidence about taking Thymogen (oglufanide).
Report a problemFND-2584820805
06AnimalNot a test of Thymogen (oglufanide) aloneAnimal study (in vivo)Mechanism
In rabbit wounds, Glu-Trp-ONa peptides decreased MMP-2 activity during early inflammation.
In plain wordsIn rabbits, the tested Glu-Trp-ONa peptides reduced MMP-2 activity during early wound inflammation.
Peptide
Thymogen (oglufanide)
Outcome
DecreaseEarly inflammatory MMP-2 activity
Study
rabbitn: not reported in source
nonhealing dermal wounds
Outcome group
Wound healing · Skin and wound
Source sentences
Summary
Subsequent zymography analyses showed that the applied peptides decreased the proteolytic activity of matrix metalloproteinases MMP-9, MMP-8, and MMP-2 in the early inflammatory phase and reversely increased the activity of MMP-9, MMP-8, and MMP-1 in the remodeling phase.
1 context sentence(design, population, supporting numbers)
Summary · context
The synthesized dipeptide (Glu-Trp-ONa) and its acylated analogue (R-Glu-Trp-ONa) were assessed in the model of nonhealing dermal wounds in rabbits in relation to their healing properties in wound closure.
In this study, Thymogen (oglufanide) was a lab tool or a carrier, part of a mix, or the subject of a lab method. This result is not evidence about taking Thymogen (oglufanide).
Report a problemFND-2584820806
07AnimalNot a test of Thymogen (oglufanide) aloneAnimal study (in vivo)Mechanism
In rabbit wounds, Glu-Trp-ONa peptides increased MMP-9 activity during remodeling.
In plain wordsIn rabbits, the tested Glu-Trp-ONa peptides increased MMP-9 activity during wound remodeling.
Peptide
Thymogen (oglufanide)
Outcome
IncreaseRemodeling MMP-9 activity
Study
rabbitn: not reported in source
nonhealing dermal wounds
Outcome group
Wound healing · Skin and wound
Source sentences
Summary
Subsequent zymography analyses showed that the applied peptides decreased the proteolytic activity of matrix metalloproteinases MMP-9, MMP-8, and MMP-2 in the early inflammatory phase and reversely increased the activity of MMP-9, MMP-8, and MMP-1 in the remodeling phase.
1 context sentence(design, population, supporting numbers)
Summary · context
The synthesized dipeptide (Glu-Trp-ONa) and its acylated analogue (R-Glu-Trp-ONa) were assessed in the model of nonhealing dermal wounds in rabbits in relation to their healing properties in wound closure.
In this study, Thymogen (oglufanide) was a lab tool or a carrier, part of a mix, or the subject of a lab method. This result is not evidence about taking Thymogen (oglufanide).
Report a problemFND-2584820807
08AnimalNot a test of Thymogen (oglufanide) aloneAnimal study (in vivo)Mechanism
In rabbit wounds, Glu-Trp-ONa peptides increased MMP-8 activity during remodeling.
In plain wordsIn rabbits, the tested Glu-Trp-ONa peptides increased MMP-8 activity during wound remodeling.
Peptide
Thymogen (oglufanide)
Outcome
IncreaseRemodeling MMP-8 activity
Study
rabbitn: not reported in source
nonhealing dermal wounds
Outcome group
Wound healing · Skin and wound
Source sentences
Summary
Subsequent zymography analyses showed that the applied peptides decreased the proteolytic activity of matrix metalloproteinases MMP-9, MMP-8, and MMP-2 in the early inflammatory phase and reversely increased the activity of MMP-9, MMP-8, and MMP-1 in the remodeling phase.
1 context sentence(design, population, supporting numbers)
Summary · context
The synthesized dipeptide (Glu-Trp-ONa) and its acylated analogue (R-Glu-Trp-ONa) were assessed in the model of nonhealing dermal wounds in rabbits in relation to their healing properties in wound closure.
In this study, Thymogen (oglufanide) was a lab tool or a carrier, part of a mix, or the subject of a lab method. This result is not evidence about taking Thymogen (oglufanide).
Report a problemFND-2584820808
09AnimalNot a test of Thymogen (oglufanide) aloneAnimal study (in vivo)Mechanism
In rabbit wounds, Glu-Trp-ONa peptides increased MMP-1 activity during remodeling.
In plain wordsIn rabbits, the tested Glu-Trp-ONa peptides increased MMP-1 activity during wound remodeling.
Peptide
Thymogen (oglufanide)
Outcome
IncreaseRemodeling MMP-1 activity
Study
rabbitn: not reported in source
nonhealing dermal wounds
Outcome group
Wound healing · Skin and wound
Source sentences
Summary
Subsequent zymography analyses showed that the applied peptides decreased the proteolytic activity of matrix metalloproteinases MMP-9, MMP-8, and MMP-2 in the early inflammatory phase and reversely increased the activity of MMP-9, MMP-8, and MMP-1 in the remodeling phase.
1 context sentence(design, population, supporting numbers)
Summary · context
The synthesized dipeptide (Glu-Trp-ONa) and its acylated analogue (R-Glu-Trp-ONa) were assessed in the model of nonhealing dermal wounds in rabbits in relation to their healing properties in wound closure.
In this study, Thymogen (oglufanide) was a lab tool or a carrier, part of a mix, or the subject of a lab method. This result is not evidence about taking Thymogen (oglufanide).
Report a problemFND-2584820809
10AnimalNot a test of Thymogen (oglufanide) aloneAnimal study (in vivo)Efficacy outcome
In rabbit wounds, the Glu-Trp-ONa peptide groups showed enhanced granulation tissue formation.
In plain wordsIn rabbits, the tested Glu-Trp-ONa peptide groups formed more granulation tissue in wounds.
Peptide
Thymogen (oglufanide)
Outcome
IncreaseGranulation tissue formation
Study
rabbitn: not reported in source
nonhealing dermal wounds
Outcome group
Wound healing · Skin and wound
Source sentences
Summary
Histological analyses of the wound sections (hematoxylin-eosin, Mallory's staining) confirmed the enhanced formation of granulation tissue and re-epithelialization in the experimental groups.
1 context sentence(design, population, supporting numbers)
Summary · context
The synthesized dipeptide (Glu-Trp-ONa) and its acylated analogue (R-Glu-Trp-ONa) were assessed in the model of nonhealing dermal wounds in rabbits in relation to their healing properties in wound closure.
In this study, Thymogen (oglufanide) was a lab tool or a carrier, part of a mix, or the subject of a lab method. This result is not evidence about taking Thymogen (oglufanide).
Report a problemFND-2584820810
11AnimalNot a test of Thymogen (oglufanide) aloneAnimal study (in vivo)Efficacy outcome
In rabbit wounds, the Glu-Trp-ONa peptide groups showed enhanced re-epithelialization.
In plain wordsIn rabbits, the tested Glu-Trp-ONa peptide groups showed enhanced renewal of the wound surface.
Peptide
Thymogen (oglufanide)
Outcome
IncreaseRe-epithelialization
Study
rabbitn: not reported in source
nonhealing dermal wounds
Outcome group
Wound healing · Skin and wound
Source sentences
Summary
Histological analyses of the wound sections (hematoxylin-eosin, Mallory's staining) confirmed the enhanced formation of granulation tissue and re-epithelialization in the experimental groups.
1 context sentence(design, population, supporting numbers)
Summary · context
The synthesized dipeptide (Glu-Trp-ONa) and its acylated analogue (R-Glu-Trp-ONa) were assessed in the model of nonhealing dermal wounds in rabbits in relation to their healing properties in wound closure.
In this study, Thymogen (oglufanide) was a lab tool or a carrier, part of a mix, or the subject of a lab method. This result is not evidence about taking Thymogen (oglufanide).
Report a problemFND-2584820811
12AnimalNot a test of Thymogen (oglufanide) aloneAnimal study (in vivo)Efficacy outcome
In rabbits with nonhealing wounds, R-Glu-Trp-ONa shortened wound healing compared with control.
In plain wordsIn rabbits, the acylated Glu-Trp analogue shortened wound healing compared with control.
Peptide
Thymogen (oglufanide)
Outcome
DecreaseAcylated analogue wound healing period versus control
Study
rabbitn: not reported in source
nonhealing dermal wounds
Comparator
Phosphate-buffered saline
Outcome group
Wound healing · Skin and wound
Source sentences
Summary
An injection of Glu-Trp-ONa and R-Glu-Trp-ONa decreased the period of wound healing in animals in comparison to the control and Solcoseryl-treated groups.
1 context sentence(design, population, supporting numbers)
Summary · context
The synthesized dipeptide (Glu-Trp-ONa) and its acylated analogue (R-Glu-Trp-ONa) were assessed in the model of nonhealing dermal wounds in rabbits in relation to their healing properties in wound closure.
In this study, Thymogen (oglufanide) was a lab tool or a carrier, part of a mix, or the subject of a lab method. This result is not evidence about taking Thymogen (oglufanide).
Report a problemFND-2584820812
13AnimalNot a test of Thymogen (oglufanide) aloneAnimal study (in vivo)Efficacy outcome
In rabbits with nonhealing wounds, R-Glu-Trp-ONa shortened wound healing compared with Solcoseryl.
In plain wordsIn rabbits, the acylated Glu-Trp analogue shortened wound healing compared with Solcoseryl.
Peptide
Thymogen (oglufanide)
Outcome
DecreaseAcylated analogue wound healing period versus Solcoseryl
Study
rabbitn: not reported in source
nonhealing dermal wounds
Comparator
Solcoseryl
Outcome group
Wound healing · Skin and wound
Source sentences
Summary
An injection of Glu-Trp-ONa and R-Glu-Trp-ONa decreased the period of wound healing in animals in comparison to the control and Solcoseryl-treated groups.
1 context sentence(design, population, supporting numbers)
Summary · context
The synthesized dipeptide (Glu-Trp-ONa) and its acylated analogue (R-Glu-Trp-ONa) were assessed in the model of nonhealing dermal wounds in rabbits in relation to their healing properties in wound closure.
In this study, Thymogen (oglufanide) was a lab tool or a carrier, part of a mix, or the subject of a lab method. This result is not evidence about taking Thymogen (oglufanide).
Report a problemFND-2584820813

AI wrote and checked these results. AI can make mistakes, so check important results against the source.

Version history

PepBank keeps every version of the data on this study. Status changes from Retraction Watch, Europe PMC and Crossref are listed with their source.

Version 2Current
21 Oct 2026, 15:58 UTC
Study results updated
Version 1
21 Oct 2026, 12:50 UTC
First added · source update from Europe PMC

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Terms as the source lists them.

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