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Study · Animal study (in vivo) · rabbit · 2015

9 results

Improving the osteogenic efficacy of BMP2 with mechano growth factor by regulating the signaling events in BMP pathway.

Deng M, Liu P, Xiao H, Zhang Y, Wang Y, Zhao J, Xu J

Cell and tissue research7 Apr 2015Cited by 12 (Europe PMC)

PMID25843688 (opens in a new tab)DOI10.1007/s00441-015-2154-3 (opens in a new tab)PepBankPUB-25843688
Publisher pagePubMedAsk about this study
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Summary

The text of this summary is not shown here, because the article license does not allow reuse. Read it at the source (opens in a new tab)

Text rights: Publisher copyright. Results still quote short attributed sentences.

Results from this study9

8 results from studies that gave the peptide. No result from this study comes from people.

  1. 01AnimalAnimal study (in vivo)Efficacy outcome

    In rabbits with 15-mm radial bone defects, MGF24E treatment upregulated endogenous BMP2 expression.

    In plain wordsIn rabbits with bone defects, MGF24E treatment raised the animals' own BMP2.

    Peptide
    MGF / PEG-MGF
    Outcome
    IncreaseEndogenous BMP2 expression
    Study

    rabbitn: not reported in source

    15-mm radial bone defect
    Outcome group
    Bone and joint · Musculoskeletal
    Studied dose
    Dose not stated

    Source sentences

    Summary
    In vivo, MGF24E treatment upregulated the endogenous BMP2 expression
    1 context sentence
    Summary · context
    Furthermore, 15-mm rabbit radial bone defects were healed with the cytokine treatments and then evaluated by radiographic examination, histological assessment and immunohistochemical analysis.
  2. 02AnimalAnimal study (in vivo)Efficacy outcome

    In rabbits with 15-mm radial bone defects, adding MGF24E to BMP2 enhanced bone mineral density compared with BMP2 alone.

    In plain wordsIn rabbits with bone defects, BMP2 plus MGF24E gave higher bone density than BMP2 alone.

    Peptide
    MGF / PEG-MGF
    Outcome
    IncreaseBone mineral density
    Study

    rabbitn: not reported in source

    15-mm radial bone defect
    Comparator
    BMP2 alone
    Outcome group
    Bone and joint · Musculoskeletal
    Studied dose
    Dose not stated

    Source sentences

    Summary
    the addition of MGF24E into the BMP2 treatment remarkably enhanced the bone mineral density (BMD), the radiographic scores and the histological restoration of the regenerated tissue against BMP2 treatment
    1 context sentence
    Summary · context
    Furthermore, 15-mm rabbit radial bone defects were healed with the cytokine treatments and then evaluated by radiographic examination, histological assessment and immunohistochemical analysis.
  3. 03AnimalAnimal study (in vivo)Efficacy outcome

    In rabbits with 15-mm radial bone defects, adding MGF24E to BMP2 enhanced radiographic scores compared with BMP2 alone.

    In plain wordsIn rabbits with bone defects, BMP2 plus MGF24E gave better X-ray scores than BMP2 alone.

    Peptide
    MGF / PEG-MGF
    Outcome
    IncreaseRadiographic scores
    Study

    rabbitn: not reported in source

    15-mm radial bone defect
    Comparator
    BMP2 alone
    Outcome group
    Bone and joint · Musculoskeletal
    Studied dose
    Dose not stated

    Source sentences

    Summary
    the addition of MGF24E into the BMP2 treatment remarkably enhanced the bone mineral density (BMD), the radiographic scores and the histological restoration of the regenerated tissue against BMP2 treatment
    1 context sentence
    Summary · context
    Furthermore, 15-mm rabbit radial bone defects were healed with the cytokine treatments and then evaluated by radiographic examination, histological assessment and immunohistochemical analysis.
  4. 04AnimalAnimal study (in vivo)Efficacy outcome

    In rabbits with 15-mm radial bone defects, adding MGF24E to BMP2 enhanced the histological restoration of the regenerated tissue compared with BMP2 alone.

    In plain wordsIn rabbits with bone defects, BMP2 plus MGF24E restored the new tissue better under the microscope than BMP2 alone.

    Peptide
    MGF / PEG-MGF
    Outcome
    IncreaseHistological restoration of regenerated tissue
    Study

    rabbitn: not reported in source

    15-mm radial bone defect
    Comparator
    BMP2 alone
    Outcome group
    Bone and joint · Musculoskeletal
    Studied dose
    Dose not stated

    Source sentences

    Summary
    the addition of MGF24E into the BMP2 treatment remarkably enhanced the bone mineral density (BMD), the radiographic scores and the histological restoration of the regenerated tissue against BMP2 treatment
    1 context sentence
    Summary · context
    Furthermore, 15-mm rabbit radial bone defects were healed with the cytokine treatments and then evaluated by radiographic examination, histological assessment and immunohistochemical analysis.
  5. 05LabIn vitro (cells)Mechanism

    In osteoblast cultures, MGF24E increased p-Smad protein expression in the BMP2-induced Smad signaling pathway.

    In plain wordsIn cells, MGF24E boosted a bone-building signal that BMP2 starts.

    Peptide
    MGF / PEG-MGF
    Outcome
    Increasep-Smad protein expression in BMP2-induced Smad signaling
    Study

    n: not reported in source

    Comparator
    BMP2 alone
    Outcome group
    Receptor activity and mechanism · Musculoskeletal
    Studied dose
    Dose not stated

    Source sentences

    Summary
    MGF24E could enhance the BMP2-induced Smad signaling pathway by upregulating the p-Smad protein expression and the downstream osteogenic gene expression.
    1 context sentence
    Summary · context
    To confirm the hypothesis, the potentials of MGF24E, BMP2 and BMP2/MGF24E combination treatments on the phosphorylation of Smad 1/5/8, the downstream osteogenesis-related gene expression and osteoblasts mineralization, are investigated with or without the blocking of Smad 5 siRNA.
  6. 06LabIn vitro (cells)Mechanism

    In osteoblast cultures, MGF24E increased downstream osteogenic gene expression in BMP2-induced signaling.

    In plain wordsIn cells, MGF24E raised the activity of bone-forming genes that BMP2 switches on.

    Peptide
    MGF / PEG-MGF
    Outcome
    IncreaseDownstream osteogenic gene expression
    Study

    n: not reported in source

    Comparator
    BMP2 alone
    Outcome group
    Bone and joint · Musculoskeletal
    Studied dose
    Dose not stated

    Source sentences

    Summary
    MGF24E could enhance the BMP2-induced Smad signaling pathway by upregulating the p-Smad protein expression and the downstream osteogenic gene expression.
    1 context sentence
    Summary · context
    To confirm the hypothesis, the potentials of MGF24E, BMP2 and BMP2/MGF24E combination treatments on the phosphorylation of Smad 1/5/8, the downstream osteogenesis-related gene expression and osteoblasts mineralization, are investigated with or without the blocking of Smad 5 siRNA.
  7. 07LabIn vitro (cells)Efficacy outcome

    In osteoblast cultures, 5 nM BMP2 with a sub-25 nM concentration of MGF24E gave higher ALP mRNA expression than BMP2 alone.

    In plain wordsIn cells, BMP2 with a small amount of MGF24E raised ALP gene activity more than BMP2 alone.

    Peptide
    MGF / PEG-MGF
    Outcome
    IncreaseALP mRNA expression
    Study

    n: not reported in source

    Comparator
    BMP2 alone
    Outcome group
    Bone and joint · Musculoskeletal
    Studied dose
    sub-25 nM MGF24E with 5 nM BMP2As given in this study.

    Source sentences

    Summary
    An amount of 5 nM BMP2 in a sub-25 nM concentration of MGF24E medium achieved a higher expression for ALP mRNA and a greater calcium mineral content compared with BMP2 alone.
    1 context sentence
    Summary · context
    To confirm the hypothesis, the potentials of MGF24E, BMP2 and BMP2/MGF24E combination treatments on the phosphorylation of Smad 1/5/8, the downstream osteogenesis-related gene expression and osteoblasts mineralization, are investigated with or without the blocking of Smad 5 siRNA.
  8. 08LabIn vitro (cells)Efficacy outcome

    In osteoblast cultures, 5 nM BMP2 with a sub-25 nM concentration of MGF24E gave a greater calcium mineral content than BMP2 alone.

    In plain wordsIn cells, BMP2 with a small amount of MGF24E gave more mineral than BMP2 alone.

    Peptide
    MGF / PEG-MGF
    Outcome
    IncreaseCalcium mineral content
    Study

    n: not reported in source

    Comparator
    BMP2 alone
    Outcome group
    Bone and joint · Musculoskeletal
    Studied dose
    sub-25 nM MGF24E with 5 nM BMP2As given in this study.

    Source sentences

    Summary
    An amount of 5 nM BMP2 in a sub-25 nM concentration of MGF24E medium achieved a higher expression for ALP mRNA and a greater calcium mineral content compared with BMP2 alone.
    1 context sentence
    Summary · context
    To confirm the hypothesis, the potentials of MGF24E, BMP2 and BMP2/MGF24E combination treatments on the phosphorylation of Smad 1/5/8, the downstream osteogenesis-related gene expression and osteoblasts mineralization, are investigated with or without the blocking of Smad 5 siRNA.

Studies that did not test the peptide alone1

In this study, MGF / PEG-MGF was a lab tool or a carrier, part of a mix, or the subject of a lab method. These results are not evidence about taking MGF / PEG-MGF.

  1. 09LabNot a test of MGF / PEG-MGF aloneIn vitro (cells)Mechanism

    In osteoblast cultures, inhibition of the MGF24E-regulated BMP pathway (Smad 5 siRNA) blocked osteogenesis induced by the dual BMP2 and MGF24E treatment.

    In plain wordsIn cells, blocking this signal with Smad 5 siRNA stopped the bone-forming effect of BMP2 plus MGF24E.

    Peptide
    MGF / PEG-MGF
    Outcome
    DecreaseOsteogenesis after inhibition of the MGF24E-regulated BMP pathway
    Study

    n: not reported in source

    Outcome group
    Receptor activity and mechanism · Musculoskeletal

    Source sentences

    Summary
    Nevertheless, the inhibition of the MGF24E-regulated BMP pathway could block osteogenesis induced by the dual treatment.
    1 context sentence
    Summary · context
    To confirm the hypothesis, the potentials of MGF24E, BMP2 and BMP2/MGF24E combination treatments on the phosphorylation of Smad 1/5/8, the downstream osteogenesis-related gene expression and osteoblasts mineralization, are investigated with or without the blocking of Smad 5 siRNA.

    In this study, MGF / PEG-MGF was a lab tool or a carrier, part of a mix, or the subject of a lab method. This result is not evidence about taking MGF / PEG-MGF.

AI wrote and checked these results. AI can make mistakes, so check important results against the source.

Version history

PepBank keeps every version of the data on this study. Status changes from Retraction Watch, Europe PMC and Crossref are listed with their source.

  1. Version 2Current

    13 Oct 2026, 21:44 UTC

    Study results updated

  2. Version 1

    13 Oct 2026, 16:31 UTC

    First added · source update from Europe PMC

Subjects

Terms as the source lists them.

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