Effect of intermittent PTH treatment on plasma glucose in osteoporosis: A randomized trial.

D'Amelio P, Sassi F, Buondonno I, Spertino E, Tamone C, Piano S, Zugna D, Richiardi L, Isaia GC

Bone27 Mar 2015Cited by 18 (Europe PMC)

PMID25827255DOI10.1016/j.bone.2015.03.018PepBankPUB-25827255

Summary

The text of this summary is not shown here, because the article license does not allow reuse. Read it at the source (opens in a new tab)

Text rights: Publisher copyright. Results still quote short attributed sentences.

Results from this study8

8 results from studies that gave the peptide. 8 results from people.

01HumanRandomized controlled trialEfficacy outcome
In osteoporotic women, PTH increased total osteocalcin versus calcium and colecalcipherol alone.
In plain wordsIn osteoporotic women, PTH increased total osteocalcin versus calcium and colecalcipherol alone.
Peptide
PTH 1-84 (parathyroid hormone)
Outcome
IncreaseTotal osteocalcin
Study
n = 39
Comparator
Calcium and colecalcipherol without PTH
Outcome group
Bone and joint · Musculoskeletal
Studied dose
Dose not stated
Source sentences
Summary
Treatment with PTH increases osteocalcin, both total (OC) and undercarboxylated (uOC), and decreases blood glucose, without influence on insulin secretion, resistance and pancreatic β cell function.
1 context sentence(design, population, supporting numbers)
Summary · context
This is a parallel, randomized controlled, open label, trial. The randomization was done by computer generated tables to allocate treatments. Forty-six postmenopausal osteoporotic non-diabetic women were assigned to treatment with calcium and colecalcipherol with (24) or without (22) PTH 1-84.
Report a problemFND-2582725502
02HumanRandomized controlled trialEfficacy outcome
In osteoporotic women, PTH increased undercarboxylated osteocalcin versus calcium and colecalcipherol alone.
In plain wordsIn osteoporotic women, PTH increased undercarboxylated osteocalcin versus calcium and colecalcipherol alone.
Peptide
PTH 1-84 (parathyroid hormone)
Outcome
IncreaseUndercarboxylated osteocalcin
Study
n = 39
Comparator
Calcium and colecalcipherol without PTH
Outcome group
Bone and joint · Musculoskeletal
Studied dose
Dose not stated
Source sentences
Summary
Treatment with PTH increases osteocalcin, both total (OC) and undercarboxylated (uOC), and decreases blood glucose, without influence on insulin secretion, resistance and pancreatic β cell function.
1 context sentence(design, population, supporting numbers)
Summary · context
This is a parallel, randomized controlled, open label, trial. The randomization was done by computer generated tables to allocate treatments. Forty-six postmenopausal osteoporotic non-diabetic women were assigned to treatment with calcium and colecalcipherol with (24) or without (22) PTH 1-84.
Report a problemFND-2582725503
03HumanRandomized controlled trialEfficacy outcome
In osteoporotic women, PTH decreased blood glucose versus calcium and colecalcipherol alone.
In plain wordsIn osteoporotic women, PTH decreased blood glucose versus calcium and colecalcipherol alone.
Peptide
PTH 1-84 (parathyroid hormone)
Outcome
DecreaseBlood glucose
Study
n = 39
Comparator
Calcium and colecalcipherol without PTH
Outcome group
Glycemic control · Metabolic and weight
Studied dose
Dose not stated
Source sentences
Summary
Treatment with PTH increases osteocalcin, both total (OC) and undercarboxylated (uOC), and decreases blood glucose, without influence on insulin secretion, resistance and pancreatic β cell function.
1 context sentence(design, population, supporting numbers)
Summary · context
This is a parallel, randomized controlled, open label, trial. The randomization was done by computer generated tables to allocate treatments. Forty-six postmenopausal osteoporotic non-diabetic women were assigned to treatment with calcium and colecalcipherol with (24) or without (22) PTH 1-84.
Report a problemFND-2582725504
04HumanRandomized controlled trialEfficacy outcome
In osteoporotic women, PTH did not influence insulin secretion, insulin resistance, or pancreatic beta-cell function versus calcium and colecalcipherol alone.
In plain wordsIn osteoporotic women, PTH did not affect insulin secretion, insulin resistance, or pancreatic beta-cell function versus calcium and colecalcipherol alone.
Peptide
PTH 1-84 (parathyroid hormone)
Outcome
No significant changeInsulin secretion, insulin resistance, and pancreatic beta-cell function
Study
n = 39
Comparator
Calcium and colecalcipherol without PTH
Outcome group
Glycemic control · Metabolic and weight
Studied dose
Dose not stated
Source sentences
Summary
Treatment with PTH increases osteocalcin, both total (OC) and undercarboxylated (uOC), and decreases blood glucose, without influence on insulin secretion, resistance and pancreatic β cell function.
1 context sentence(design, population, supporting numbers)
Summary · context
This is a parallel, randomized controlled, open label, trial. The randomization was done by computer generated tables to allocate treatments. Forty-six postmenopausal osteoporotic non-diabetic women were assigned to treatment with calcium and colecalcipherol with (24) or without (22) PTH 1-84.
Report a problemFND-2582725505
05HumanRandomized controlled trialEfficacy outcome
In osteoporotic women, PTH did not influence fat distribution versus calcium and colecalcipherol alone.
In plain wordsIn osteoporotic women, PTH did not influence fat distribution versus calcium and colecalcipherol alone.
Peptide
PTH 1-84 (parathyroid hormone)
Outcome
No significant changeFat distribution
Study
n = 39
Comparator
Calcium and colecalcipherol without PTH
Outcome group
Body composition · Metabolic and weight
Studied dose
Dose not stated
Source sentences
Summary
Treatment with PTH does not influence fat distribution and adipokine production.
1 context sentence(design, population, supporting numbers)
Summary · context
This is a parallel, randomized controlled, open label, trial. The randomization was done by computer generated tables to allocate treatments. Forty-six postmenopausal osteoporotic non-diabetic women were assigned to treatment with calcium and colecalcipherol with (24) or without (22) PTH 1-84.
Report a problemFND-2582725506
06HumanRandomized controlled trialEfficacy outcome
In osteoporotic women, PTH did not influence adipokine production versus calcium and colecalcipherol alone.
In plain wordsIn osteoporotic women, PTH did not influence adipokine production versus calcium and colecalcipherol alone.
Peptide
PTH 1-84 (parathyroid hormone)
Outcome
No significant changeAdipokine production
Study
n = 39
Comparator
Calcium and colecalcipherol without PTH
Outcome group
Glycemic control · Metabolic and weight
Studied dose
Dose not stated
Source sentences
Summary
Treatment with PTH does not influence fat distribution and adipokine production.
1 context sentence(design, population, supporting numbers)
Summary · context
This is a parallel, randomized controlled, open label, trial. The randomization was done by computer generated tables to allocate treatments. Forty-six postmenopausal osteoporotic non-diabetic women were assigned to treatment with calcium and colecalcipherol with (24) or without (22) PTH 1-84.
Report a problemFND-2582725507
07HumanNon-randomized trialSafety outcome
In osteoporotic women, no significant adverse events were reported in the PTH trial.
In plain wordsIn osteoporotic women, no significant adverse events were reported in the PTH trial.
Peptide
PTH 1-84 (parathyroid hormone)
Outcome
Not applicableSignificant adverse events
Study
n: not reported in source
Outcome group
Adverse events · Whole body
Studied dose
Dose not stated
Source sentences
Summary
There were no significance adverse events.
1 context sentence(design, population, supporting numbers)
Summary · context
This is a parallel, randomized controlled, open label, trial. The randomization was done by computer generated tables to allocate treatments. Forty-six postmenopausal osteoporotic non-diabetic women were assigned to treatment with calcium and colecalcipherol with (24) or without (22) PTH 1-84.
Report a problemFND-2582725501
08HumanObservational studyMechanism
In osteoporotic women, mediation analysis suggested that osteocalcin partly mediated PTH's blood glucose effect, with less mediation by undercarboxylated osteocalcin.
In plain wordsIn osteoporotic women, analysis linked PTH's blood glucose effect partly to osteocalcin and less to undercarboxylated osteocalcin.
Peptide
PTH 1-84 (parathyroid hormone)
Outcome
Not applicableOsteocalcin mediation of glucose effect
Study
n = 39
Outcome group
Glycemic control · Metabolic and weight
Studied dose
Dose not stated
Source sentences
Summary
The results of the mediation analyses suggest a total effect of PTH on blood glucose, moderately mediated by OC and to a less extent by uOC.
1 context sentence(design, population, supporting numbers)
Summary · context
This is a parallel, randomized controlled, open label, trial. The randomization was done by computer generated tables to allocate treatments. Forty-six postmenopausal osteoporotic non-diabetic women were assigned to treatment with calcium and colecalcipherol with (24) or without (22) PTH 1-84.
Report a problemFND-2582725508

AI wrote and checked these results. AI can make mistakes, so check important results against the source.

Version history

PepBank keeps every version of the data on this study. Status changes from Retraction Watch, Europe PMC and Crossref are listed with their source.

Version 2Current
28 Oct 2026, 02:03 UTC
Study results updated
Version 1
27 Oct 2026, 16:37 UTC
First added · source update from Europe PMC

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