In pigs, an oral L. plantarum vaccine expressing E2 with thymosin alpha‑1 gave significantly different, better, immune responses than the vaccine expressing E2 alone.
In plain wordsIn pigs, adding thymosin alpha‑1 to an oral swine fever vaccine gave better immune responses than the vaccine without it.
- Peptide
- Thymosin alpha-1
- Outcome
- IncreaseImmune responses with Tα1 adjuvant versus E2 alone
- Study
pign: not reported in source
Oral recombinant Lactobacillus plantarum vaccine against classical swine fever virus- Comparator
- L. plantarum/pYG-E2 (E2 without Tα1)
- Outcome group
- Immune response · Immune and inflammation
- Studied dose
- Dose not stated · oralAs given in this study (pig).
Source sentences
Significant differences (P < 0.05) in the levels of immune responses were observed between L. plantarum/pYG-E2-Tα1 and L. plantarum/pYG-E2, suggesting a better immunogenicity of L. plantarum/pYG-E2-Tα1 as a result of the Tα1 molecular adjuvant that can enhance immune responsiveness and augment speci…
1 context sentence(design, population, supporting numbers)
In this study, genetically engineered Lactobacillus plantarum bacteria expressing CSFV E2 protein alone (L. plantarum/pYG-E2) and in combination with Tα1 (L. plantarum/pYG-E2-Tα1) were developed, and the immunogenicity of each as an oral vaccine to induce protective immunity against CSFV in pigs was evaluated.