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Study · Animal study (in vivo) · 2015

8 results

Mechano growth factor (MGF) and transforming growth factor (TGF)-β3 functionalized silk scaffolds enhance articular hyaline cartilage regeneration in rabbit model.

Luo Z, Jiang L, Xu Y, Li H, Xu W, Wu S, Wang Y, Tang Z, Lv Y, Yang L

Biomaterials18 Mar 2015Cited by 102 (Europe PMC)

PMID25818452 (opens in a new tab)DOI10.1016/j.biomaterials.2015.01.001 (opens in a new tab)PepBankPUB-25818452
Publisher pagePubMedAsk about this study
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Summary

The text of this summary is not shown here, because the article license does not allow reuse. Read it at the source (opens in a new tab)

Text rights: Publisher copyright. Results still quote short attributed sentences.

Results from this study8

6 results from studies that gave the peptide. No result from this study comes from people.

  1. 01AnimalAnimal study (in vivo)Efficacy outcome

    In silk scaffold experiments in vitro and in vivo, adding MGF to TGF-β3 increased cell recruitment more than TGF-β3 alone, up to 1.8 times and 2 times higher.

    In plain wordsIn lab and animal tests, MGF with TGF-β3 drew in more cells than TGF-β3 alone.

    Peptide
    MGF / PEG-MGF
    Outcome
    IncreaseCell recruitment, MGF plus TGF-β3 versus TGF-β3, in vitro and in vivo
    Study

    n: not reported in source

    Comparator
    TGF-β3 alone
    Outcome group
    Bone and joint · Musculoskeletal
    Studied dose
    Dose not stated

    Source sentences

    Summary
    Combination of MGF and TGF-β3 significantly increased cell recruitment up to 1.8 times and 2 times higher than TGF-β3 did in vitro and in vivo.
    1 context sentence
    Summary · context
    Here we demonstrated that one of alternative isoforms of IGF-1, mechano growth factor (MGF) acted synergistically with transforming growth factor β3 (TGF-β3) embedded in silk fibroin scaffolds to induce chemotactic homing and chondrogenic differentiation of mesenchymal stem cells (MSCs).
  2. 02AnimalAnimal study (in vivo)Efficacy outcome

    At 2 months after subcutaneous implantation, scaffolds with TGF-β3 and MGF held more cartilage-like extracellular matrix than scaffolds with TGF-β3 alone.

    In plain wordsIn animals, scaffolds with MGF and TGF-β3 grew more cartilage-like tissue than scaffolds with TGF-β3 alone.

    Peptide
    MGF / PEG-MGF
    Outcome
    IncreaseCartilage-like extracellular matrix at 2 months
    Study

    n: not reported in source

    Comparator
    TGF-β3 modified scaffolds (ST)
    Outcome group
    Bone and joint · Musculoskeletal
    Studied dose
    Dose not stated · scaffold implanted subcutaneously · 2 monthsAs given in this study.

    Source sentences

    Summary
    Similarly, more cartilage-like extracellular matrix and less fibrillar collagen were detected in STM scaffolds than that in TGF-β3 modified scaffolds (ST) at 2 months after subcutaneous implantation.
  3. 03AnimalAnimal study (in vivo)Efficacy outcome

    At 2 months after subcutaneous implantation, scaffolds with TGF-β3 and MGF held less fibrillar collagen than scaffolds with TGF-β3 alone.

    In plain wordsIn animals, scaffolds with MGF and TGF-β3 had less fibrillar collagen than scaffolds with TGF-β3 alone.

    Peptide
    MGF / PEG-MGF
    Outcome
    DecreaseFibrillar collagen at 2 months
    Study

    n: not reported in source

    Comparator
    TGF-β3 modified scaffolds (ST)
    Outcome group
    Bone and joint · Musculoskeletal
    Studied dose
    Dose not stated · scaffold implanted subcutaneously · 2 monthsAs given in this study.

    Source sentences

    Summary
    Similarly, more cartilage-like extracellular matrix and less fibrillar collagen were detected in STM scaffolds than that in TGF-β3 modified scaffolds (ST) at 2 months after subcutaneous implantation.
  4. 04LabIn vitro (cells)Efficacy outcome

    In TGF-β3-induced hMSC chondrogenesis in vitro, MGF increased Collagen II secretion.

    In plain wordsIn cells, MGF raised Collagen II production in stem cells that were driven to become cartilage cells with TGF-β3.

    Peptide
    MGF / PEG-MGF
    Outcome
    IncreaseCollagen II secretion in TGF-β3-induced chondrogenesis
    Study

    n: not reported in source

    hMSC chondrogenesis induced by TGF-β3
    Comparator
    TGF-β3-induced chondrogenesis without MGF
    Outcome group
    Bone and joint · Musculoskeletal
    Studied dose
    Dose not stated

    Source sentences

    Summary
    MGF increased Collagen II and aggrecan secretion of TGF-β3 induced hMSCs chondrogenesis
  5. 05LabIn vitro (cells)Efficacy outcome

    In TGF-β3-induced hMSC chondrogenesis in vitro, MGF increased aggrecan secretion.

    In plain wordsIn cells, MGF raised aggrecan production in stem cells that were driven to become cartilage cells with TGF-β3.

    Peptide
    MGF / PEG-MGF
    Outcome
    IncreaseAggrecan secretion in TGF-β3-induced chondrogenesis
    Study

    n: not reported in source

    hMSC chondrogenesis induced by TGF-β3
    Comparator
    TGF-β3-induced chondrogenesis without MGF
    Outcome group
    Bone and joint · Musculoskeletal
    Studied dose
    Dose not stated

    Source sentences

    Summary
    MGF increased Collagen II and aggrecan secretion of TGF-β3 induced hMSCs chondrogenesis
  6. 06LabIn vitro (cells)Efficacy outcome

    In TGF-β3-induced hMSC chondrogenesis in vitro, MGF decreased Collagen I.

    In plain wordsIn cells, MGF lowered Collagen I in stem cells that were driven to become cartilage cells with TGF-β3.

    Peptide
    MGF / PEG-MGF
    Outcome
    DecreaseCollagen I in TGF-β3-induced chondrogenesis
    Study

    n: not reported in source

    hMSC chondrogenesis induced by TGF-β3
    Comparator
    TGF-β3-induced chondrogenesis without MGF
    Outcome group
    Bone and joint · Musculoskeletal
    Studied dose
    Dose not stated

    Source sentences

    Summary
    Moreover, MGF increased Collagen II and aggrecan secretion of TGF-β3 induced hMSCs chondrogenesis, but decreased Collagen I in vitro.

Studies that did not test the peptide alone2

In this study, MGF / PEG-MGF was a lab tool or a carrier, part of a mix, or the subject of a lab method. These results are not evidence about taking MGF / PEG-MGF.

  1. 07AnimalNot a test of MGF / PEG-MGF aloneAnimal study (in vivo)Efficacy outcome

    At 7 days after subcutaneous implantation, silk fibroin scaffolds with TGF-β3 and MGF recruited more CD29+/CD44+ cells (P<0.05). The abstract does not name the comparator.

    In plain wordsIn animals, scaffolds with TGF-β3 and MGF drew in more stem-like cells. The abstract does not name the comparison group.

    Peptide
    MGF / PEG-MGF
    Outcome
    IncreaseCD29+/CD44+ cell recruitment at 7 days, TGF-β3 plus MGF scaffold
    Study

    n: not reported in source

    Outcome group
    Bone and joint · Musculoskeletal

    Source sentences

    Summary
    At 7 days after subcutaneous implantation, TGF-β3 and MGF functionalized silk fibroin scaffolds (STM) recruited more CD29+/CD44+cells (P<0.05).

    In this study, MGF / PEG-MGF was a lab tool or a carrier, part of a mix, or the subject of a lab method. This result is not evidence about taking MGF / PEG-MGF.

  2. 08AnimalNot a test of MGF / PEG-MGF aloneAnimal study (in vivo)Efficacy outcome

    In a rabbit osteochondral defect model, scaffolds with TGF-β3 and MGF showed the best integration and an architecture similar to native hyaline cartilage (P<0.05). The abstract does not name the comparator.

    In plain wordsIn rabbits, scaffolds with TGF-β3 and MGF integrated best and looked most like natural cartilage. The abstract does not name the comparison group.

    Peptide
    MGF / PEG-MGF
    Outcome
    IncreaseTissue integration and histological score, TGF-β3 plus MGF scaffold
    Study

    rabbitn: not reported in source

    osteochondral defect in articular joint
    Outcome group
    Bone and joint · Musculoskeletal

    Source sentences

    Summary
    STM scaffolds showed the best integration into host tissues, similar architecture and collagen organization to native hyaline cartilage, as evidenced by immunostaining of aggrecan, collagen II and collagen I, as well as Safranin O and Masson's trichrome staining, and histological evalution based on…

    In this study, MGF / PEG-MGF was a lab tool or a carrier, part of a mix, or the subject of a lab method. This result is not evidence about taking MGF / PEG-MGF.

AI wrote and checked these results. AI can make mistakes, so check important results against the source.

Version history

PepBank keeps every version of the data on this study. Status changes from Retraction Watch, Europe PMC and Crossref are listed with their source.

  1. Version 2Current

    13 Oct 2026, 21:44 UTC

    Study results updated

  2. Version 1

    13 Oct 2026, 16:31 UTC

    First added · source update from Europe PMC

Subjects

Terms as the source lists them.

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