Cerebrolysin Accelerates Metamorphosis and Attenuates Aging-Accelerating Effect of High Temperature in Drosophila Melanogaster.

Navrotskaya V, Oxenkrug G, Vorobyova L, Sharma H, Muresanu D, Summergrad P

American journal of neuroprotection and neuroregeneration1 Oct 2014Cited by 5 (Europe PMC)

PMID25798213PMCIDPMC4367862DOI10.1166/ajnn.2014.1083PepBankPUB-25798213

Summary

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Text rights: Publisher copyright. Results still quote short attributed sentences.

Results from this study4

4 results from studies that gave the peptide. No result from this study comes from people.

01AnimalAnimal study (in vivo)Efficacy outcome
In Drosophila melanogaster, Cerebrolysin accelerated metamorphosis.
In plain wordsIn flies, Cerebrolysin accelerated metamorphosis.
Peptide
Cerebrolysin
Outcome
Not applicableMetamorphosis
Study
Drosophila melanogastern: not reported in source
Flies maintained at 23 °C and 28 °C ambient temperature
Outcome group
Cell proliferation and differentiation · Whole body
Studied dose
Dose not stated
Source sentences
Summary
CBL accelerated metamorphosis, exerted strong tendency (p = 0.04) to prolong life span in female but not in male flies, and attenuated aging-accelerating effect of high (28 °C) ambient temperature in both female and male flies.
1 context sentence(design, population, supporting numbers)
Summary · context
To investigate possible involvement of TRP-KYN pathway in mechanisms of neuroprotective effect of CBL, we evaluated CBL effects on metamorphosis and life span of Drosophila melanogaster maintained at 23 °C and 28 °C ambient temperature.
Report a problemFND-2579821301
02AnimalAnimal study (in vivo)Efficacy outcome
In female Drosophila melanogaster, Cerebrolysin showed a strong tendency to prolong life span.
In plain wordsIn female flies, Cerebrolysin showed a tendency to increase life span.
Peptide
Cerebrolysin
Outcome
IncreaseFemale life span
Study
Drosophila melanogastern: not reported in source
Flies maintained at 23 °C and 28 °C ambient temperature
Outcome group
Aging markers · Aging and longevity
Studied dose
Dose not stated
Source sentences
Summary
CBL accelerated metamorphosis, exerted strong tendency (p = 0.04) to prolong life span in female but not in male flies, and attenuated aging-accelerating effect of high (28 °C) ambient temperature in both female and male flies.
1 context sentence(design, population, supporting numbers)
Summary · context
To investigate possible involvement of TRP-KYN pathway in mechanisms of neuroprotective effect of CBL, we evaluated CBL effects on metamorphosis and life span of Drosophila melanogaster maintained at 23 °C and 28 °C ambient temperature.
Report a problemFND-2579821302
03AnimalAnimal study (in vivo)Efficacy outcome
In male Drosophila melanogaster, Cerebrolysin did not show the life span prolongation tendency observed in females.
In plain wordsIn male flies, Cerebrolysin did not show the tendency to increase life span observed in females.
Peptide
Cerebrolysin
Outcome
Direction not reportedMale life span
Study
Drosophila melanogastern: not reported in source
Flies maintained at 23 °C and 28 °C ambient temperature
Outcome group
Aging markers · Aging and longevity
Studied dose
Dose not stated
Source sentences
Summary
CBL accelerated metamorphosis, exerted strong tendency (p = 0.04) to prolong life span in female but not in male flies, and attenuated aging-accelerating effect of high (28 °C) ambient temperature in both female and male flies.
1 context sentence(design, population, supporting numbers)
Summary · context
To investigate possible involvement of TRP-KYN pathway in mechanisms of neuroprotective effect of CBL, we evaluated CBL effects on metamorphosis and life span of Drosophila melanogaster maintained at 23 °C and 28 °C ambient temperature.
Report a problemFND-2579821303
04AnimalAnimal study (in vivo)Efficacy outcome
In female and male Drosophila melanogaster, Cerebrolysin attenuated the aging-accelerating effect of 28 °C ambient temperature.
In plain wordsIn female and male flies, Cerebrolysin reduced accelerated aging at 28 °C.
Peptide
Cerebrolysin
Outcome
DecreaseHigh-temperature accelerated aging
Study
Drosophila melanogastern: not reported in source
Flies maintained at 23 °C and 28 °C ambient temperature
Outcome group
Aging markers · Aging and longevity
Studied dose
Dose not stated
Source sentences
Summary
CBL accelerated metamorphosis, exerted strong tendency (p = 0.04) to prolong life span in female but not in male flies, and attenuated aging-accelerating effect of high (28 °C) ambient temperature in both female and male flies.
1 context sentence(design, population, supporting numbers)
Summary · context
To investigate possible involvement of TRP-KYN pathway in mechanisms of neuroprotective effect of CBL, we evaluated CBL effects on metamorphosis and life span of Drosophila melanogaster maintained at 23 °C and 28 °C ambient temperature.
Report a problemFND-2579821304

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Version history

PepBank keeps every version of the data on this study. Status changes from Retraction Watch, Europe PMC and Crossref are listed with their source.

Version 2Current
14 Oct 2026, 05:02 UTC
Study results updated
Version 1
14 Oct 2026, 01:46 UTC
First added · source update from Europe PMC

Subjects

Terms as the source lists them.

Publication types

Keywords

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