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Study · Not a test of the peptide alone · 2015

2 results

Synthesis of Mono-PEGylated Growth Hormone Releasing Peptide-2 and Investigation of its Biological Activity.

Hu X, Xu B, Zhou Z

AAPS PharmSciTech12 Mar 2015Cited by 2 (Europe PMC)

PMID25761386 (opens in a new tab)PMCIDPMC4674637 (opens in a new tab)DOI10.1208/s12249-015-0307-z (opens in a new tab)PepBankPUB-25761386
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Summary

The text of this summary is not shown here, because the article license does not allow reuse. Read it at the source (opens in a new tab)

Text rights: Publisher copyright. Results still quote short attributed sentences.

Results from this study2

No result from this study comes from a test of the peptide.

Studies that did not test the peptide alone2

In this study, GHRP-2 was a lab tool or a carrier, part of a mix, or the subject of a lab method. These results are not evidence about taking GHRP-2.

  1. 01AnimalNot a test of GHRP-2 aloneAnimal study (in vivo)Pharmacokinetics

    In rats, mono-PEGylated GHRP‑2 gave a more stable activity than GHRP‑2, suggesting a longer plasma half-life without a large loss of biological activity.

    In plain wordsIn rats, the PEG-attached form of GHRP‑2 kept its activity longer than GHRP‑2 itself.

    Peptide
    GHRP-2
    Outcome
    IncreaseStability of biological activity of mono-PEGylated GHRP-2
    Study

    ratn: not reported in source

    rats
    Comparator
    GHRP-2
    Outcome group
    Pharmacokinetics · Pharmacology

    Source sentences

    Summary
    The evaluation of the biological activity for the products showed that the mono-PEGylated GHRP-2 gave a more stable activity than GHRP-2, suggesting that PEGylation led to the increase in the half-life of GHRP-2 in plasma without greatly impairing the biological activity.
    1 context sentence
    Summary · context
    The product was purified by cation exchange chromatography, and its biological activity was conducted in rats.

    In this study, GHRP-2 was a lab tool or a carrier, part of a mix, or the subject of a lab method. This result is not evidence about taking GHRP-2.

  2. 02LabNot a test of GHRP-2 aloneIn vitro (cell-free)Other

    Mono-PEGylated GHRP‑2 was obtained as the major product in anhydrous aprotic solvents such as DMF and DMSO at a mPEG-NHS ester to GHRP‑2 molar ratio of 0.8:1.

    In plain wordsIn lab chemistry, a PEG-attached form of GHRP‑2 was obtained as the main product under set conditions.

    Peptide
    GHRP-2
    Outcome
    Not applicableSynthesis of mono-PEGylated GHRP-2
    Study

    n: not reported in source

    Outcome group
    Receptor activity and mechanism · Pharmacology

    Source sentences

    Summary
    The desired mono-PEGylated GHRP-2 as the major product was readily obtained in anhydrous aprotic solvent, such as dimethyl formamide (DMF) and dimethylsulfoxide (DMSO), when the molar ratio of mPEG-NHS ester to GHRP-2 was fixed to be 0.8:1.
    1 context sentence
    Summary · context
    The product was purified by cation exchange chromatography, and its biological activity was conducted in rats.

    In this study, GHRP-2 was a lab tool or a carrier, part of a mix, or the subject of a lab method. This result is not evidence about taking GHRP-2.

AI wrote and checked these results. AI can make mistakes, so check important results against the source.

Version history

PepBank keeps every version of the data on this study. Status changes from Retraction Watch, Europe PMC and Crossref are listed with their source.

  1. Version 2Current

    13 Oct 2026, 21:44 UTC

    Study results updated

  2. Version 1

    13 Oct 2026, 16:31 UTC

    First added · source update from Europe PMC

Subjects

Terms as the source lists them.

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