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Study · In vitro (cells) · 2014

1 result

Effect of GLY-HIS-LYS and its copper complex on TGF-β secretion in normal human dermal fibroblasts.

Gruchlik A, Chodurek E, Dzierzewicz Z

Acta poloniae pharmaceutica1 Nov 2014Cited by 13 (Europe PMC)

PMID25745767 (opens in a new tab)PepBankPUB-25745767
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Summary

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Text rights: Publisher copyright. Results still quote short attributed sentences.

Results from this study1

1 result from studies that gave the peptide. No result from this study comes from people.

  1. 01LabIn vitro (cells)Mechanism

    In normal human dermal fibroblasts, 1 nM GHK‑Cu decreased IGF-2-dependent TGF-β1 secretion.

    In plain wordsIn cells, GHK‑Cu reduced the release of the scar-related signal TGF-β1 triggered by IGF-2.

    Peptide
    GHK-Cu
    Outcome
    DecreaseIGF-2-dependent TGF-β1 secretion
    Study

    humann: not reported in source

    normal human dermal fibroblasts
    Outcome group
    Wound healing · Skin and wound
    Studied dose
    1 nMAs given in this study (human).

    Source sentences

    Summary
    GHK and its copper complex and free copper ions decreased IGF-2-dependent TGF-β1 secretion.
    1 context sentence
    Summary · context
    In the present study, the influence of 1 nM solutions of GHK, GHK-Cu and CuCl2, on IGF-2-dependent TGF-β1 secretion in normal human dermal fibroblasts cells was investigated.

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Version history

PepBank keeps every version of the data on this study. Status changes from Retraction Watch, Europe PMC and Crossref are listed with their source.

  1. Version 3Current

    9 Oct 2026, 18:17 UTC

    Study results updated

  2. Version 2

    9 Oct 2026, 03:03 UTC

    Study data updated · source update from Europe PMC

  3. Version 1

    9 Oct 2026, 02:56 UTC

    First added · source update from Europe PMC

Subjects

Terms as the source lists them.

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