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Study · Animal study (in vivo) · mouse · 2014

8 results

[The dynamics of behavioral and neuroreceptor effects after acute and long-term noopept administration in C57BL/6 and BALB/c mice].

Kovalev GI, Kondrakhin EA, Salimov RM, Neznamov GG

Eksperimental'naia i klinicheskaia farmakologiia1 Jan 2014

PMID25739185 (opens in a new tab)PepBankPUB-25739185
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Summary

The text of this summary is not shown here, because the article license does not allow reuse. Read it at the source (opens in a new tab)

Text rights: Publisher copyright. Results still quote short attributed sentences.

Results from this study8

8 results from studies that gave the peptide. No result from this study comes from people.

  1. 01AnimalAnimal study (in vivo)Efficacy outcome

    In C57BL/6 mice, Noopept did not affect anxiety at any experimental step.

    In plain wordsIn mice of the C57BL/6 strain, Noopept did not change anxiety.

    Peptide
    Noopept (omberacetam)
    Outcome
    No significant changeAnxiety
    Study

    micen: not reported in source

    C57BL/6 mice
    Outcome group
    Anxiety and mood · Mental health and mood
    Studied dose
    1 mg/kg/dayAs given in this study (mice).

    Source sentences

    Summary
    The dipeptide failed to affect the anxiety and exploration activity in C57BL/6 mice at each of 3 steps of experimental session.
  2. 02AnimalAnimal study (in vivo)Efficacy outcome

    In C57BL/6 mice, Noopept did not affect exploration activity at any experimental step.

    In plain wordsIn mice of the C57BL/6 strain, Noopept did not change exploration.

    Peptide
    Noopept (omberacetam)
    Outcome
    No significant changeExploration activity
    Study

    micen: not reported in source

    C57BL/6 mice
    Outcome group
    Cognition and memory · Nervous system and cognition
    Studied dose
    1 mg/kg/dayAs given in this study (mice).

    Source sentences

    Summary
    The dipeptide failed to affect the anxiety and exploration activity in C57BL/6 mice at each of 3 steps of experimental session.
    1 context sentence
    Summary · context
    The effect of acute, 7-fold and 14-fold noopept (1 mg/kg/day) administration on the dynamics of anxiolitic and nootropic behavioral effects in cross-maze, as well as their correlations with NMDA- and BDZ-receptor density was studied in inbred mice strains, differing in exploratory and emotional stat…
  3. 03AnimalAnimal study (in vivo)Mechanism

    In C57BL/6 mice, Noopept changed MK-801 binding B(max) only after single administration.

    In plain wordsIn mice of the C57BL/6 strain, Noopept changed NMDA receptor binding only after a single dose.

    Peptide
    Noopept (omberacetam)
    Outcome
    Direction not reportedNMDA receptor binding B(max)
    Study

    micen: not reported in source

    C57BL/6 mice
    Outcome group
    Receptor activity and mechanism · Nervous system and cognition
    Studied dose
    1 mg/kg/dayAs given in this study (mice).

    Source sentences

    Summary
    In this strain the B(max) values of [3H]-MK-801 and [3H]-Flunitrazepam binding changed only after single administration.
    1 context sentence
    Summary · context
    The effect of acute, 7-fold and 14-fold noopept (1 mg/kg/day) administration on the dynamics of anxiolitic and nootropic behavioral effects in cross-maze, as well as their correlations with NMDA- and BDZ-receptor density was studied in inbred mice strains, differing in exploratory and emotional stat…
  4. 04AnimalAnimal study (in vivo)Mechanism

    In C57BL/6 mice, Noopept changed flunitrazepam binding B(max) only after single administration.

    In plain wordsIn mice of the C57BL/6 strain, Noopept changed benzodiazepine receptor binding only after a single dose.

    Peptide
    Noopept (omberacetam)
    Outcome
    Direction not reportedBDZ receptor binding B(max)
    Study

    micen: not reported in source

    C57BL/6 mice
    Outcome group
    Receptor activity and mechanism · Nervous system and cognition
    Studied dose
    1 mg/kg/dayAs given in this study (mice).

    Source sentences

    Summary
    In this strain the B(max) values of [3H]-MK-801 and [3H]-Flunitrazepam binding changed only after single administration.
    1 context sentence
    Summary · context
    The effect of acute, 7-fold and 14-fold noopept (1 mg/kg/day) administration on the dynamics of anxiolitic and nootropic behavioral effects in cross-maze, as well as their correlations with NMDA- and BDZ-receptor density was studied in inbred mice strains, differing in exploratory and emotional stat…
  5. 05AnimalAnimal study (in vivo)Efficacy outcome

    In BALB/c mice, Noopept produced an anxiolytic effect that reached its maximum on the seventh day.

    In plain wordsIn mice of the BALB/c strain, Noopept reduced anxiety, with the largest effect on the seventh day.

    Peptide
    Noopept (omberacetam)
    Outcome
    DecreaseAnxiolytic effect
    Study

    micen: not reported in source

    BALB/c mice
    Outcome group
    Anxiety and mood · Mental health and mood
    Studied dose
    1 mg/kg/dayAs given in this study (mice).

    Source sentences

    Summary
    In respect to BALB/c mice noopept induced both the anxiolitic and nootropic effects reaching their maximum on 7th day.
    1 context sentence
    Summary · context
    The effect of acute, 7-fold and 14-fold noopept (1 mg/kg/day) administration on the dynamics of anxiolitic and nootropic behavioral effects in cross-maze, as well as their correlations with NMDA- and BDZ-receptor density was studied in inbred mice strains, differing in exploratory and emotional stat…
  6. 06AnimalAnimal study (in vivo)Efficacy outcome

    In BALB/c mice, Noopept produced a nootropic effect that reached its maximum on the seventh day.

    In plain wordsIn mice of the BALB/c strain, Noopept improved cognitive performance, with the largest effect on the seventh day.

    Peptide
    Noopept (omberacetam)
    Outcome
    IncreaseNootropic effect
    Study

    micen: not reported in source

    BALB/c mice
    Outcome group
    Cognition and memory · Nervous system and cognition
    Studied dose
    1 mg/kg/dayAs given in this study (mice).

    Source sentences

    Summary
    In respect to BALB/c mice noopept induced both the anxiolitic and nootropic effects reaching their maximum on 7th day.
    1 context sentence
    Summary · context
    The effect of acute, 7-fold and 14-fold noopept (1 mg/kg/day) administration on the dynamics of anxiolitic and nootropic behavioral effects in cross-maze, as well as their correlations with NMDA- and BDZ-receptor density was studied in inbred mice strains, differing in exploratory and emotional stat…
  7. 07AnimalAnimal study (in vivo)Mechanism

    In Noopept-treated BALB/c mice, hippocampal NMDA receptor binding dynamics corresponded to exploratory efficacy dynamics.

    In plain wordsIn mice of the BALB/c strain, changes in NMDA receptor binding corresponded to exploratory effects during Noopept treatment.

    Peptide
    Noopept (omberacetam)
    Outcome
    Not applicableNMDA binding and exploratory efficacy dynamics
    Study

    micen: not reported in source

    BALB/c mice
    Outcome group
    Receptor activity and mechanism · Nervous system and cognition
    Studied dose
    1 mg/kg/dayAs given in this study (mice).

    Source sentences

    Summary
    In BALB/c strain the dynamics of hippocampal NMDA-receptor binding corresponds to the dynamics of exploratory efficacy whereas the dynamics of BDZ-receptors in prefrontal cortex was reciprocally to dynamics of anxiety level.
    1 context sentence
    Summary · context
    The effect of acute, 7-fold and 14-fold noopept (1 mg/kg/day) administration on the dynamics of anxiolitic and nootropic behavioral effects in cross-maze, as well as their correlations with NMDA- and BDZ-receptor density was studied in inbred mice strains, differing in exploratory and emotional stat…
  8. 08AnimalAnimal study (in vivo)Mechanism

    In Noopept-treated BALB/c mice, prefrontal BDZ receptor dynamics varied reciprocally with anxiety dynamics.

    In plain wordsIn mice of the BALB/c strain, benzodiazepine receptor changes varied inversely with anxiety during Noopept treatment.

    Peptide
    Noopept (omberacetam)
    Outcome
    Not applicableBDZ binding and anxiety dynamics
    Study

    micen: not reported in source

    BALB/c mice
    Outcome group
    Receptor activity and mechanism · Nervous system and cognition
    Studied dose
    1 mg/kg/dayAs given in this study (mice).

    Source sentences

    Summary
    In BALB/c strain the dynamics of hippocampal NMDA-receptor binding corresponds to the dynamics of exploratory efficacy whereas the dynamics of BDZ-receptors in prefrontal cortex was reciprocally to dynamics of anxiety level.
    1 context sentence
    Summary · context
    The effect of acute, 7-fold and 14-fold noopept (1 mg/kg/day) administration on the dynamics of anxiolitic and nootropic behavioral effects in cross-maze, as well as their correlations with NMDA- and BDZ-receptor density was studied in inbred mice strains, differing in exploratory and emotional stat…

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Version history

PepBank keeps every version of the data on this study. Status changes from Retraction Watch, Europe PMC and Crossref are listed with their source.

  1. Version 2Current

    21 Oct 2026, 15:58 UTC

    Study results updated

  2. Version 1

    21 Oct 2026, 12:50 UTC

    First added · source update from Europe PMC

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