In rats given fluvoxamine as pups, which delayed growth, reduced body weight, raised anxiety and disturbed learning, semax treatment largely compensated these negative consequences.
In plain wordsIn rats given fluvoxamine as pups, semax treatment largely offset the later growth, weight, anxiety and learning problems.
- Peptide
- Semax
- Outcome
- MixedCorrection of neonatal fluvoxamine effects (growth, body weight, anxiety, learning)
- Study
ratn: not reported in source
Neonatal fluvoxamine administration (postnatal days 1-14)- Outcome group
- Overall treatment effect · Nervous system and cognition
- Studied dose
- 0.05 mg/kg · intranasal · postnatal days 15 to 28As given in this study (rat).
Source sentences
The negative consequences of neonatal FA administration were largely compensated by Semax.
2 context sentences(design, population, supporting numbers)
Furthermore, FA administration increased the anxiety level and disturbed the learning ability of animals.
Fluvoxamine was injected intraperitoneally at a dose of 10 mg/kg from postnatal days 1 to 14, and semax was injected intranasally at a dose of 0.05 mg/kg from postnatal days 15 to 28.