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Study · Animal study (in vivo) · rat · 2015

7 results

Tripeptide-copper complex GHK-Cu (II) transiently improved healing outcome in a rat model of ACL reconstruction.

Fu SC, Cheuk YC, Chiu WY, Yung SH, Rolf CG, Chan KM

Journal of orthopaedic research : official publication of the Orthopaedic Research Society10 Apr 2015Cited by 15 (Europe PMC)

PMID25731775 (opens in a new tab)DOI10.1002/jor.22831 (opens in a new tab)PepBankPUB-25731775
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Summary

The text of this summary is not shown here, because the article license does not allow reuse. Read it at the source (opens in a new tab)

Text rights: Publisher copyright. Results still quote short attributed sentences.

Results from this study7

7 results from studies that gave the peptide. No result from this study comes from people.

  1. 01AnimalAnimal study (in vivo)Efficacy outcome

    In rats after ACL reconstruction, GHK‑Cu groups had a smaller side-to-side difference in knee laxity than the saline group at 6 weeks (p = 0.009).

    In plain wordsIn rats after ACL surgery, knee looseness was smaller with GHK‑Cu than with saline at 6 weeks.

    Peptide
    GHK-Cu
    Outcome
    DecreaseKnee laxity at 6 weeks
    Study

    ratn: not reported in source

    ACL reconstruction
    Comparator
    Saline
    Outcome group
    Tendon and ligament healing · Musculoskeletal
    Studied dose
    0.3 or 3 mg/ml · intra-articular injection · once weekly for 4 weeks, from week 2As given in this study (rat).

    Source sentences

    Summary
    At 6 weeks post-ACLR, GHK-Cu groups resulted in a smaller side-to-side difference in knee laxity as compared to the saline group (p = 0.009)
    2 context sentences
    Summary · context
    Seventy-two rats underwent unilateral ACLR were randomized to saline, 0.3 or 3 mg/ml GHK-Cu groups (n = 24).
    Summary · context
    Post-operational intra-articular injections were given from week 2, once a week, for 4 weeks.
  2. 02AnimalAnimal study (in vivo)Efficacy outcome

    In rats after ACL reconstruction, knee laxity did not differ significantly between GHK‑Cu and saline groups at 12 weeks.

    In plain wordsIn rats after ACL surgery, knee looseness did not differ between GHK‑Cu and saline at 12 weeks.

    Peptide
    GHK-Cu
    Outcome
    No significant changeKnee laxity at 12 weeks
    Study

    ratn: not reported in source

    ACL reconstruction
    Comparator
    Saline
    Outcome group
    Tendon and ligament healing · Musculoskeletal
    Studied dose
    0.3 or 3 mg/ml · intra-articular injection · once weekly for 4 weeks, from week 2As given in this study (rat).

    Source sentences

    Summary
    but there was no significant difference at 12 weeks post-operation.
    2 context sentences
    Summary · context
    Seventy-two rats underwent unilateral ACLR were randomized to saline, 0.3 or 3 mg/ml GHK-Cu groups (n = 24).
    Summary · context
    Post-operational intra-articular injections were given from week 2, once a week, for 4 weeks.
  3. 03AnimalAnimal study (in vivo)Efficacy outcome

    In rats after ACL reconstruction, the graft complex in the 0.3 mg/ml GHK‑Cu group had higher stiffness than the saline group at 6 weeks (p = 0.026).

    In plain wordsIn rats after ACL surgery, the repaired graft was stiffer with 0.3 mg/ml GHK‑Cu than with saline at 6 weeks.

    Peptide
    GHK-Cu
    Outcome
    IncreaseGraft stiffness at 6 weeks
    Study

    ratn: not reported in source

    ACL reconstruction
    Comparator
    Saline
    Outcome group
    Tendon and ligament healing · Musculoskeletal
    Studied dose
    0.3 mg/ml · intra-articular injection · once weekly for 4 weeks, from week 2As given in this study (rat).

    Source sentences

    Summary
    The graft complex in the 0.3 mg/ml GHK-Cu group had higher stiffness than saline group at 6 weeks post-operation (p = 0.026)
    2 context sentences
    Summary · context
    Seventy-two rats underwent unilateral ACLR were randomized to saline, 0.3 or 3 mg/ml GHK-Cu groups (n = 24).
    Summary · context
    Post-operational intra-articular injections were given from week 2, once a week, for 4 weeks.
  4. 04AnimalAnimal study (in vivo)Efficacy outcome

    In rats after ACL reconstruction, ultimate load did not differ significantly among treatment groups.

    In plain wordsIn rats after ACL surgery, graft breaking strength did not differ between GHK‑Cu and saline.

    Peptide
    GHK-Cu
    Outcome
    No significant changeUltimate load of graft
    Study

    ratn: not reported in source

    ACL reconstruction
    Comparator
    Saline
    Outcome group
    Tendon and ligament healing · Musculoskeletal
    Studied dose
    0.3 or 3 mg/ml · intra-articular injection · once weekly for 4 weeks, from week 2As given in this study (rat).

    Source sentences

    Summary
    but there was no significant difference in ultimate load, gait parameters, and histological scores among treatment groups.
    2 context sentences
    Summary · context
    Seventy-two rats underwent unilateral ACLR were randomized to saline, 0.3 or 3 mg/ml GHK-Cu groups (n = 24).
    Summary · context
    Post-operational intra-articular injections were given from week 2, once a week, for 4 weeks.
  5. 05AnimalAnimal study (in vivo)Efficacy outcome

    In rats after ACL reconstruction, gait parameters did not differ significantly among treatment groups.

    In plain wordsIn rats after ACL surgery, walking measures did not differ between GHK‑Cu and saline.

    Peptide
    GHK-Cu
    Outcome
    No significant changeGait parameters
    Study

    ratn: not reported in source

    ACL reconstruction
    Comparator
    Saline
    Outcome group
    Tendon and ligament healing · Musculoskeletal
    Studied dose
    0.3 or 3 mg/ml · intra-articular injection · once weekly for 4 weeks, from week 2As given in this study (rat).

    Source sentences

    Summary
    but there was no significant difference in ultimate load, gait parameters, and histological scores among treatment groups.
    2 context sentences
    Summary · context
    Seventy-two rats underwent unilateral ACLR were randomized to saline, 0.3 or 3 mg/ml GHK-Cu groups (n = 24).
    Summary · context
    Post-operational intra-articular injections were given from week 2, once a week, for 4 weeks.
  6. 06AnimalAnimal study (in vivo)Efficacy outcome

    In rats after ACL reconstruction, histological scores did not differ significantly among treatment groups.

    In plain wordsIn rats after ACL surgery, tissue scores under the microscope did not differ between GHK‑Cu and saline.

    Peptide
    GHK-Cu
    Outcome
    No significant changeHistological scores
    Study

    ratn: not reported in source

    ACL reconstruction
    Comparator
    Saline
    Outcome group
    Tendon and ligament healing · Musculoskeletal
    Studied dose
    0.3 or 3 mg/ml · intra-articular injection · once weekly for 4 weeks, from week 2As given in this study (rat).

    Source sentences

    Summary
    but there was no significant difference in ultimate load, gait parameters, and histological scores among treatment groups.
    2 context sentences
    Summary · context
    Seventy-two rats underwent unilateral ACLR were randomized to saline, 0.3 or 3 mg/ml GHK-Cu groups (n = 24).
    Summary · context
    Post-operational intra-articular injections were given from week 2, once a week, for 4 weeks.
  7. 07AnimalAnimal study (in vivo)Efficacy outcome

    In rats after ACL reconstruction, all grafts failed mid-substance during the pull-out test, in every group.

    In plain wordsIn rats after ACL surgery, all grafts broke in the middle during the pull-out test, in every group.

    Peptide
    GHK-Cu
    Outcome
    Not applicableGraft failure mode in pull-out test
    Study

    ratn: not reported in source

    ACL reconstruction
    Outcome group
    Tendon and ligament healing · Musculoskeletal
    Studied dose
    0.3 or 3 mg/ml · intra-articular injection · once weekly for 4 weeks, from week 2As given in this study (rat).

    Source sentences

    Summary
    All grafts failed mid-substance during pull-out test.
    2 context sentences
    Summary · context
    Seventy-two rats underwent unilateral ACLR were randomized to saline, 0.3 or 3 mg/ml GHK-Cu groups (n = 24).
    Summary · context
    Post-operational intra-articular injections were given from week 2, once a week, for 4 weeks.

AI wrote and checked these results. AI can make mistakes, so check important results against the source.

Version history

PepBank keeps every version of the data on this study. Status changes from Retraction Watch, Europe PMC and Crossref are listed with their source.

  1. Version 3Current

    9 Oct 2026, 18:17 UTC

    Study results updated

  2. Version 2

    9 Oct 2026, 03:03 UTC

    Study data updated · source update from Europe PMC

  3. Version 1

    9 Oct 2026, 02:56 UTC

    First added · source update from Europe PMC

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