In hypoxic rat neuronal cultures, NAP regulated cellular antioxidants through more than one route of neuroprotective action.
In plain wordsIn cells from rats under low oxygen, NAP regulated cellular antioxidants through more than one route.
- Peptide
- Davunetide
- Outcome
- Direction not reportedCellular antioxidant regulation
- Study
ratn: not reported in source
primary neuronal culture under hypoxia- Outcome group
- Receptor activity and mechanism · Nervous system and cognition
- Studied dose
- 15fM · 72 hAs given in this study (rat).
Source sentences
In the present study, we report that NAP regulates a major clad of cellular antioxidants and there is an involvement of more than one route of action in neuroprotection during hypoxia.
1 context sentence(design, population, supporting numbers)
Primary neuronal culture of rat was subjected to cellular hypoxia by limiting the oxygen concentration to 0.5% for 72 h and observing the prophylactic efficacies of 15fM NAP by conventional cell death assays using flow cytometry.