Impaired spatial working memory after anterior thalamic lesions: recovery with cerebrolysin and enrichment.

Loukavenko EA, Wolff M, Poirier GL, Dalrymple-Alford JC

Brain structure & function1 Mar 2015Cited by 17 (Europe PMC)

PMID25725627DOI10.1007/s00429-015-1015-xPepBankPUB-25725627

Publisher page PubMedAsk about this study

Summary

The text of this summary is not shown here, because the article license does not allow reuse. Read it at the source (opens in a new tab)

Text rights: Publisher copyright. Results still quote short attributed sentences.

Results from this study5

4 results from studies that gave the peptide. No result from this study comes from people.

01AnimalAnimal study (in vivo)Efficacy outcome
In rats with anterior thalamic lesions, Cerebrolysin improved spatial working memory compared with saline in standard housing.
In plain wordsIn rats with thalamic lesions, Cerebrolysin improved working memory compared with saline in standard housing.
Peptide
Cerebrolysin
Outcome
IncreaseSpatial working memory
Study
ratn: not reported in source
Anterior thalamic nuclei lesion rats
Comparator
Saline in standard housing
Outcome group
Cognition and memory · Nervous system and cognition
Studied dose
Dose not stated · 30-dayAs given in this study (rat).
Source sentences
Summary
Both cerebrolysin and enrichment substantially improved this working memory deficit, including accuracy on trials that required attention to distal cues for successful performance.
2 context sentences(design, population, supporting numbers)
Summary · context
As expected, ATN lesions in standard-housed rats given saline produced severely impaired reinforced spatial alternation when compared to standard-housed rats with sham lesions.
Summary · context
Recovery of spatial working memory after ATN lesions was examined using a 30-day administration of the neurotrophin cerebrolysin and/or an enriched housing environment.
Report a problemFND-2572562701
02AnimalAnimal study (in vivo)Efficacy outcome
In rats with anterior thalamic lesions, Cerebrolysin improved distal-cue trial accuracy compared with saline in standard housing.
In plain wordsIn rats with thalamic lesions, Cerebrolysin improved memory trial accuracy with distant cues compared with saline in standard housing.
Peptide
Cerebrolysin
Outcome
IncreaseDistal cue trial accuracy
Study
ratn: not reported in source
Anterior thalamic nuclei lesion rats
Comparator
Saline in standard housing
Outcome group
Cognition and memory · Nervous system and cognition
Studied dose
Dose not stated · 30-dayAs given in this study (rat).
Source sentences
Summary
Both cerebrolysin and enrichment substantially improved this working memory deficit, including accuracy on trials that required attention to distal cues for successful performance.
2 context sentences(design, population, supporting numbers)
Summary · context
As expected, ATN lesions in standard-housed rats given saline produced severely impaired reinforced spatial alternation when compared to standard-housed rats with sham lesions.
Summary · context
Recovery of spatial working memory after ATN lesions was examined using a 30-day administration of the neurotrophin cerebrolysin and/or an enriched housing environment.
Report a problemFND-2572562702
03AnimalAnimal study (in vivo)Efficacy outcome
In rats with thalamic lesions, adding Cerebrolysin to enrichment improved working memory more than enrichment alone at a 40 s delay.
In plain wordsIn rats with thalamic lesions, Cerebrolysin plus enrichment improved memory more than enrichment alone at a 40 s delay.
Peptide
Cerebrolysin
Outcome
IncreaseWorking memory at increased delay
Study
ratn: not reported in source
Anterior thalamic nuclei lesion rats
Comparator
Enrichment alone
Outcome group
Cognition and memory · Nervous system and cognition
Studied dose
Dose not stated · 30-dayAs given in this study (rat).
Source sentences
Summary
The combination of cerebrolysin and enrichment was more effective than either treatment alone when the delay between successive runs in a trial was increased to 40 s.
1 context sentence(design, population, supporting numbers)
Summary · context
Recovery of spatial working memory after ATN lesions was examined using a 30-day administration of the neurotrophin cerebrolysin and/or an enriched housing environment.
Report a problemFND-2572562703
04AnimalAnimal study (in vivo)Mechanism
In rats with anterior thalamic lesions, retrosplenial c-Fos expression remained low compared with intact rats after Cerebrolysin and enrichment treatments.
In plain wordsIn rats with thalamic lesions, brain c-Fos expression remained low compared with intact rats after Cerebrolysin and enrichment treatments.
Peptide
Cerebrolysin
Outcome
No significant changeRetrosplenial c-Fos expression
Study
ratn: not reported in source
Anterior thalamic nuclei lesion rats
Comparator
Intact rats
Outcome group
Receptor activity and mechanism · Nervous system and cognition
Studied dose
Dose not stated · 30-dayAs given in this study (rat).
Source sentences
Summary
Compared to the intact rats, ATN lesions in standard-housed groups produced substantial reduction in c-Fos expression in the retrosplenial cortex, which remained low after cerebrolysin and enrichment treatments.
1 context sentence(design, population, supporting numbers)
Summary · context
Recovery of spatial working memory after ATN lesions was examined using a 30-day administration of the neurotrophin cerebrolysin and/or an enriched housing environment.
Report a problemFND-2572562705

Studies that did not test the peptide alone1

In this study, Cerebrolysin was a lab tool or a carrier, part of a mix, or the subject of a lab method. These results are not evidence about taking Cerebrolysin.

05AnimalNot a test of Cerebrolysin aloneAnimal study (in vivo)Efficacy outcome
In rats with thalamic lesions, Cerebrolysin plus enrichment improved working memory more than Cerebrolysin alone at a 40 s delay.
In plain wordsIn rats with thalamic lesions, Cerebrolysin plus enrichment improved memory more than Cerebrolysin alone at a 40 s delay.
Peptide
Cerebrolysin
Outcome
IncreaseWorking memory at increased delay
Study
ratn: not reported in source
Anterior thalamic nuclei lesion rats
Comparator
Cerebrolysin alone
Outcome group
Cognition and memory · Nervous system and cognition
Source sentences
Summary
The combination of cerebrolysin and enrichment was more effective than either treatment alone when the delay between successive runs in a trial was increased to 40 s.
1 context sentence(design, population, supporting numbers)
Summary · context
Recovery of spatial working memory after ATN lesions was examined using a 30-day administration of the neurotrophin cerebrolysin and/or an enriched housing environment.
In this study, Cerebrolysin was a lab tool or a carrier, part of a mix, or the subject of a lab method. This result is not evidence about taking Cerebrolysin.
Report a problemFND-2572562704

AI wrote and checked these results. AI can make mistakes, so check important results against the source.

Version history

PepBank keeps every version of the data on this study. Status changes from Retraction Watch, Europe PMC and Crossref are listed with their source.

Version 2Current
14 Oct 2026, 05:02 UTC
Study results updated
Version 1
14 Oct 2026, 01:46 UTC
First added · source update from Europe PMC

Subjects

Terms as the source lists them.

PepBank is a research reference. Talk to a doctor before you use any peptide.