Random-start GnRH antagonist for emergency fertility preservation: a self-controlled trial.

Checa MA, Brassesco M, Sastre M, Gómez M, Herrero J, Marque L, Brassesco A, Espinós JJ

International journal of women's health12 Feb 2015Cited by 14 (Europe PMC)

PMID25709506PMCIDPMC4332315DOI10.2147/ijwh.s66743PepBankPUB-25709506

Read at source PubMedAsk about this study

Summary

The text of this summary is not shown here, because the article license does not allow reuse. Read it at the source (opens in a new tab)

Text rights: CC BY-NC. Results still quote short attributed sentences.

Results from this study6

6 results from studies that gave the peptide. 6 results from people.

01HumanNon-randomized trialEfficacy outcome
In egg donors, mature oocyte yield was comparable between ganirelix protocol B and standard protocol A.
In plain wordsIn egg donors, mature oocyte yield was comparable between ganirelix protocol B and standard protocol A.
Peptide
Ganirelix
Outcome
Direction not reportedMature oocytes with day 10 start
Study
n = 11
Comparator
Standard protocol A
Analysis
Primary
Outcome group
Sex hormones and fertility · Reproductive and sexual health
Studied dose
Dose not stated · started on day 10 of the cycle and continued until estradiol levels were below 60 pg/dLAs given in this study (human).
Measurements
Mature oocytes
13 oocytes
protocol B mean
Mature oocytes SD
9.1 oocytes
protocol B
Mature oocytes
14.3 oocytes
protocol A mean
Mature oocytes SD
4.6 oocytes
protocol A
Source sentences
Summary
Results from this study show that the number of mature oocytes retrieved was comparable across the different protocols (14.3±4.6 in the standard protocol versus 13.0±9.1 and 13.2±5.2 in protocols B and C, respectively; values expressed as mean ± standard deviation).
4 context sentences(design, population, supporting numbers)
Summary · context
A self-controlled pilot clinical trial (NCT01385332) was performed in an acute-care teaching hospital and in two private reproductive centers in Barcelona, Spain.
Summary · context
Eleven egg donors participated in the study.
Summary · context
Two random-start gonadotropin-releasing hormone (GnRH) antagonist protocols were assessed in which ganirelix was initiated on either day 10 (protocol B) or on day 20 (protocol C) of the menstrual cycle and was continued until estradiol levels were below 60 pg/dL.
Summary · context
These protocols were compared with a standard protocol (protocol A).
Report a problemFND-2570950601
02HumanNon-randomized trialEfficacy outcome
In egg donors, mature oocyte yield was comparable between ganirelix protocol C and standard protocol A.
In plain wordsIn egg donors, mature oocyte yield was comparable between ganirelix protocol C and standard protocol A.
Peptide
Ganirelix
Outcome
Direction not reportedMature oocytes with day 20 start
Study
n = 11
Comparator
Standard protocol A
Analysis
Primary
Outcome group
Sex hormones and fertility · Reproductive and sexual health
Studied dose
Dose not stated · started on day 20 of the cycle and continued until estradiol levels were below 60 pg/dLAs given in this study (human).
Measurements
Mature oocytes
13.2 oocytes
protocol C mean
Mature oocytes SD
5.2 oocytes
protocol C
Mature oocytes
14.3 oocytes
protocol A mean
Mature oocytes SD
4.6 oocytes
protocol A
Source sentences
Summary
Results from this study show that the number of mature oocytes retrieved was comparable across the different protocols (14.3±4.6 in the standard protocol versus 13.0±9.1 and 13.2±5.2 in protocols B and C, respectively; values expressed as mean ± standard deviation).
4 context sentences(design, population, supporting numbers)
Summary · context
A self-controlled pilot clinical trial (NCT01385332) was performed in an acute-care teaching hospital and in two private reproductive centers in Barcelona, Spain.
Summary · context
Eleven egg donors participated in the study.
Summary · context
Two random-start gonadotropin-releasing hormone (GnRH) antagonist protocols were assessed in which ganirelix was initiated on either day 10 (protocol B) or on day 20 (protocol C) of the menstrual cycle and was continued until estradiol levels were below 60 pg/dL.
Summary · context
These protocols were compared with a standard protocol (protocol A).
Report a problemFND-2570950602
03HumanNon-randomized trialEfficacy outcome
In egg donors, days to lower estradiol were similar between ganirelix protocol B and standard protocol A.
In plain wordsIn egg donors, days to lower estradiol were similar between ganirelix protocol B and standard protocol A.
Peptide
Ganirelix
Outcome
Direction not reportedDays to lower estradiol with protocol B
Study
n = 11
Comparator
Standard protocol A
Outcome group
Sex hormones and fertility · Reproductive and sexual health
Studied dose
Dose not stated · started on day 10 of the cycle and continued until estradiol levels were below 60 pg/dLAs given in this study (human).
Source sentences
Summary
The mean number of days needed for a GnRH antagonist to lower estradiol levels, as well as the ongoing pregnancy rates, were also similar when protocols B (stimulation in follicular phase) and C (stimulation on luteal phase) were compared with protocol A (standard stimulation).
4 context sentences(design, population, supporting numbers)
Summary · context
A self-controlled pilot clinical trial (NCT01385332) was performed in an acute-care teaching hospital and in two private reproductive centers in Barcelona, Spain.
Summary · context
Eleven egg donors participated in the study.
Summary · context
Two random-start gonadotropin-releasing hormone (GnRH) antagonist protocols were assessed in which ganirelix was initiated on either day 10 (protocol B) or on day 20 (protocol C) of the menstrual cycle and was continued until estradiol levels were below 60 pg/dL.
Summary · context
These protocols were compared with a standard protocol (protocol A).
Report a problemFND-2570950603
04HumanNon-randomized trialEfficacy outcome
In egg donors, days to lower estradiol were similar between ganirelix protocol C and standard protocol A.
In plain wordsIn egg donors, days to lower estradiol were similar between ganirelix protocol C and standard protocol A.
Peptide
Ganirelix
Outcome
Direction not reportedDays to lower estradiol with protocol C
Study
n = 11
Comparator
Standard protocol A
Outcome group
Sex hormones and fertility · Reproductive and sexual health
Studied dose
Dose not stated · started on day 20 of the cycle and continued until estradiol levels were below 60 pg/dLAs given in this study (human).
Source sentences
Summary
The mean number of days needed for a GnRH antagonist to lower estradiol levels, as well as the ongoing pregnancy rates, were also similar when protocols B (stimulation in follicular phase) and C (stimulation on luteal phase) were compared with protocol A (standard stimulation).
4 context sentences(design, population, supporting numbers)
Summary · context
A self-controlled pilot clinical trial (NCT01385332) was performed in an acute-care teaching hospital and in two private reproductive centers in Barcelona, Spain.
Summary · context
Eleven egg donors participated in the study.
Summary · context
Two random-start gonadotropin-releasing hormone (GnRH) antagonist protocols were assessed in which ganirelix was initiated on either day 10 (protocol B) or on day 20 (protocol C) of the menstrual cycle and was continued until estradiol levels were below 60 pg/dL.
Summary · context
These protocols were compared with a standard protocol (protocol A).
Report a problemFND-2570950604
05HumanNon-randomized trialEfficacy outcome
Ongoing pregnancy rates were similar after ganirelix protocol B and standard protocol A.
In plain wordsOngoing pregnancy rates were similar after ganirelix protocol B and standard protocol A.
Peptide
Ganirelix
Outcome
Direction not reportedOngoing pregnancy with protocol B
Study
n: not reported in source
Comparator
Standard protocol A
Outcome group
Sex hormones and fertility · Reproductive and sexual health
Studied dose
Dose not stated · started on day 10 of the cycle and continued until estradiol levels were below 60 pg/dLAs given in this study (human).
Source sentences
Summary
The mean number of days needed for a GnRH antagonist to lower estradiol levels, as well as the ongoing pregnancy rates, were also similar when protocols B (stimulation in follicular phase) and C (stimulation on luteal phase) were compared with protocol A (standard stimulation).
4 context sentences(design, population, supporting numbers)
Summary · context
A self-controlled pilot clinical trial (NCT01385332) was performed in an acute-care teaching hospital and in two private reproductive centers in Barcelona, Spain.
Summary · context
Eleven egg donors participated in the study.
Summary · context
Two random-start gonadotropin-releasing hormone (GnRH) antagonist protocols were assessed in which ganirelix was initiated on either day 10 (protocol B) or on day 20 (protocol C) of the menstrual cycle and was continued until estradiol levels were below 60 pg/dL.
Summary · context
These protocols were compared with a standard protocol (protocol A).
Report a problemFND-2570950605
06HumanNon-randomized trialEfficacy outcome
Ongoing pregnancy rates were similar after ganirelix protocol C and standard protocol A.
In plain wordsOngoing pregnancy rates were similar after ganirelix protocol C and standard protocol A.
Peptide
Ganirelix
Outcome
Direction not reportedOngoing pregnancy with protocol C
Study
n: not reported in source
Comparator
Standard protocol A
Outcome group
Sex hormones and fertility · Reproductive and sexual health
Studied dose
Dose not stated · started on day 20 of the cycle and continued until estradiol levels were below 60 pg/dLAs given in this study (human).
Source sentences
Summary
The mean number of days needed for a GnRH antagonist to lower estradiol levels, as well as the ongoing pregnancy rates, were also similar when protocols B (stimulation in follicular phase) and C (stimulation on luteal phase) were compared with protocol A (standard stimulation).
4 context sentences(design, population, supporting numbers)
Summary · context
A self-controlled pilot clinical trial (NCT01385332) was performed in an acute-care teaching hospital and in two private reproductive centers in Barcelona, Spain.
Summary · context
Eleven egg donors participated in the study.
Summary · context
Two random-start gonadotropin-releasing hormone (GnRH) antagonist protocols were assessed in which ganirelix was initiated on either day 10 (protocol B) or on day 20 (protocol C) of the menstrual cycle and was continued until estradiol levels were below 60 pg/dL.
Summary · context
These protocols were compared with a standard protocol (protocol A).
Report a problemFND-2570950606

AI wrote and checked these results. AI can make mistakes, so check important results against the source.

Version history

PepBank keeps every version of the data on this study. Status changes from Retraction Watch, Europe PMC and Crossref are listed with their source.

Version 2Current
28 Oct 2026, 02:03 UTC
Study results updated
Version 1
27 Oct 2026, 16:35 UTC
First added · source update from Europe PMC

Subjects

Terms as the source lists them.

Publication types

Keywords

PepBank is a research reference. Talk to a doctor before you use any peptide.