Longitudinal assessment of oxytocin efficacy on bone and bone marrow fat masses in a rabbit osteoporosis model through 3.0-T magnetic resonance spectroscopy and micro-CT.

Qiu Y, Yao J, Wu X, Zhou B, Shao H, Hua T, Xiong Z, Tang G

Osteoporosis international : a journal established as result of cooperation between the European Foundation for Osteoporosis and the National Osteoporosis Foundation of the USA22 Oct 2014Cited by 15 (Europe PMC)

PMID25690480DOI10.1007/s00198-014-2933-9PepBankPUB-25690480

Publisher page PubMedAsk about this study

Jump to 5 results

Summary

The text of this summary is not shown here, because the article license does not allow reuse. Read it at the source (opens in a new tab)

Text rights: Publisher copyright. Results still quote short attributed sentences.

Results from this study5

5 results from studies that gave the peptide. No result from this study comes from people.

01AnimalAnimal study (in vivo)Efficacy outcome
In ovariectomized rabbits, oxytocin treatment significantly decreased bone marrow fat fraction from the eighth week versus untreated osteoporotic rabbits.
In plain wordsIn rabbits with osteoporosis, oxytocin lowered bone marrow fat compared with untreated osteoporotic rabbits.
Peptide
Oxytocin
Outcome
DecreaseBone marrow fat fraction (FF)
Study
rabbitn: not reported in source
Ovariectomy-induced osteoporosis model
Comparator
Osteoporosis (OP) group
Outcome group
Bone and joint · Musculoskeletal
Studied dose
Dose not stated · subcutaneous · 8 weeksAs given in this study (rabbit).
Source sentences
Summary
The FF values of the OT group significantly decreased (p = 0.044), but the TMD values increased (p = 0.042) from eighth week compared with those of the OP group.
2 context sentences(design, population, supporting numbers)
Summary · context
Sixty 20-week-old female rabbits were randomly assigned into three groups.
Summary · context
The OT group was subcutaneously injected with OT daily from the second week after OVX for 8 weeks.
Report a problemFND-2569048001
02AnimalAnimal study (in vivo)Efficacy outcome
In ovariectomized rabbits, oxytocin treatment significantly increased tissue mineral density from the eighth week versus untreated osteoporotic rabbits.
In plain wordsIn rabbits with osteoporosis, oxytocin raised bone tissue mineral density compared with untreated osteoporotic rabbits.
Peptide
Oxytocin
Outcome
IncreaseTissue mineral density (TMD)
Study
rabbitn: not reported in source
Ovariectomy-induced osteoporosis model
Comparator
Osteoporosis (OP) group
Outcome group
Bone and joint · Musculoskeletal
Studied dose
Dose not stated · subcutaneous · 8 weeksAs given in this study (rabbit).
Source sentences
Summary
The FF values of the OT group significantly decreased (p = 0.044), but the TMD values increased (p = 0.042) from eighth week compared with those of the OP group.
2 context sentences(design, population, supporting numbers)
Summary · context
Sixty 20-week-old female rabbits were randomly assigned into three groups.
Summary · context
The OT group was subcutaneously injected with OT daily from the second week after OVX for 8 weeks.
Report a problemFND-2569048002
03AnimalAnimal study (in vivo)Efficacy outcome
In ovariectomized rabbits, oxytocin treatment significantly decreased adipocyte diameter from the eighth week versus untreated osteoporotic rabbits.
In plain wordsIn rabbits with osteoporosis, oxytocin made marrow fat cells smaller compared with untreated osteoporotic rabbits.
Peptide
Oxytocin
Outcome
DecreaseMarrow adipocyte diameter
Study
rabbitn: not reported in source
Ovariectomy-induced osteoporosis model
Comparator
Osteoporosis (OP) group
Outcome group
Bone and joint · Musculoskeletal
Studied dose
Dose not stated · subcutaneous · 8 weeksAs given in this study (rabbit).
Source sentences
Summary
The adypocyte diameter of the OT group significantly decreased (p = 0.041) from eighth week and then adypocyte density did so too from tenth week, compared with those of the OP group at the same time point.
2 context sentences(design, population, supporting numbers)
Summary · context
Sixty 20-week-old female rabbits were randomly assigned into three groups.
Summary · context
The OT group was subcutaneously injected with OT daily from the second week after OVX for 8 weeks.
Report a problemFND-2569048003
04AnimalAnimal study (in vivo)Efficacy outcome
In ovariectomized rabbits, oxytocin treatment significantly decreased adipocyte density from the tenth week versus untreated osteoporotic rabbits.
In plain wordsIn rabbits with osteoporosis, oxytocin lowered the number of marrow fat cells compared with untreated osteoporotic rabbits.
Peptide
Oxytocin
Outcome
DecreaseMarrow adipocyte density
Study
rabbitn: not reported in source
Ovariectomy-induced osteoporosis model
Comparator
Osteoporosis (OP) group
Outcome group
Bone and joint · Musculoskeletal
Studied dose
Dose not stated · subcutaneous · 8 weeksAs given in this study (rabbit).
Source sentences
Summary
The adypocyte diameter of the OT group significantly decreased (p = 0.041) from eighth week and then adypocyte density did so too from tenth week, compared with those of the OP group at the same time point.
2 context sentences(design, population, supporting numbers)
Summary · context
Sixty 20-week-old female rabbits were randomly assigned into three groups.
Summary · context
The OT group was subcutaneously injected with OT daily from the second week after OVX for 8 weeks.
Report a problemFND-2569048004
05AnimalAnimal study (in vivo)Efficacy outcome
In ovariectomized rabbits, adipocyte measures in the oxytocin group did not differ from the sham control group until the 12th week.
In plain wordsIn rabbits, marrow fat cell measures after oxytocin stayed similar to sham-operated controls up to week 12.
Peptide
Oxytocin
Outcome
No significant changeAdipocyte calculation versus control group
Study
rabbitn: not reported in source
Ovariectomy-induced osteoporosis model
Comparator
Control (sham surgery) group
Outcome group
Bone and joint · Musculoskeletal
Studied dose
Dose not stated · subcutaneous · 8 weeksAs given in this study (rabbit).
Source sentences
Summary
No difference in adypocyte calculation was found between the OT and control groups until the 12th week after operation.
2 context sentences(design, population, supporting numbers)
Summary · context
Sixty 20-week-old female rabbits were randomly assigned into three groups.
Summary · context
The OT group was subcutaneously injected with OT daily from the second week after OVX for 8 weeks.
Report a problemFND-2569048005

AI wrote and checked these results. AI can make mistakes, so check important results against the source.

Version history

PepBank keeps every version of the data on this study. Status changes from Retraction Watch, Europe PMC and Crossref are listed with their source.

Version 2Current
11 Oct 2026, 01:30 UTC
Study results updated
Version 1
9 Oct 2026, 02:50 UTC
First added · source update from Europe PMC

Subjects

Terms as the source lists them.

Publication types

MeSH terms

PepBank is a research reference. Talk to a doctor before you use any peptide.