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Study · Animal study (in vivo) · mouse · 2015

5 results

Localized delivery of mechano-growth factor E-domain peptide via polymeric microstructures improves cardiac function following myocardial infarction.

Peña JR, Pinney JR, Ayala P, Desai TA, Goldspink PH

Biomaterials16 Jan 2015Cited by 22 (Europe PMC)

PMID25678113 (opens in a new tab)PMCIDPMC4328136 (opens in a new tab)DOI10.1016/j.biomaterials.2014.12.050 (opens in a new tab)PepBankPUB-25678113
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Summary

The text of this summary is not shown here, because the article license does not allow reuse. Read it at the source (opens in a new tab)

Text rights: Publisher copyright. Results still quote short attributed sentences.

Results from this study5

5 results from studies that gave the peptide. No result from this study comes from people.

  1. 01AnimalAnimal study (in vivo)Efficacy outcome

    In mice after myocardial infarction, MGF E-domain peptide delivered in eluting microrods decreased mortality.

    In plain wordsIn mice after a heart attack, the MGF E-domain peptide delivered in microrods lowered deaths.

    Peptide
    MGF / PEG-MGF
    Outcome
    DecreaseMortality after myocardial infarction
    Study

    mousen: not reported in source

    Myocardial infarction by coronary artery ligation
    Outcome group
    Mortality · Cardiovascular
    Studied dose
    Dose not stated · intramuscular injection of peptide-eluting microrodsAs given in this study (mouse).

    Source sentences

    Summary
    Delivery of the E-domain peptide eluting microrods decreased mortality, ameliorated the decline in hemodynamics, and delayed decompensation.
    1 context sentence
    Summary · context
    Peptide eluting microrods and empty microrods were delivered via intramuscular injection following coronary artery ligation in mice.
  2. 02AnimalAnimal study (in vivo)Efficacy outcome

    In mice after myocardial infarction, MGF E-domain peptide delivered in eluting microrods ameliorated the decline in hemodynamics.

    In plain wordsIn mice after a heart attack, the MGF E-domain peptide in microrods eased the decline in heart blood-flow measures.

    Peptide
    MGF / PEG-MGF
    Outcome
    IncreaseDecline in hemodynamics after myocardial infarction
    Study

    mousen: not reported in source

    Myocardial infarction by coronary artery ligation
    Outcome group
    Heart function · Cardiovascular
    Studied dose
    Dose not stated · intramuscular injection of peptide-eluting microrodsAs given in this study (mouse).

    Source sentences

    Summary
    ameliorated the decline in hemodynamics, and delayed decompensation.
    1 context sentence
    Summary · context
    Peptide eluting microrods and empty microrods were delivered via intramuscular injection following coronary artery ligation in mice.
  3. 03AnimalAnimal study (in vivo)Efficacy outcome

    In mice after myocardial infarction, MGF E-domain peptide delivered in eluting microrods delayed decompensation.

    In plain wordsIn mice after a heart attack, the MGF E-domain peptide in microrods delayed heart failure worsening.

    Peptide
    MGF / PEG-MGF
    Outcome
    DecreaseDecompensation after myocardial infarction
    Study

    mousen: not reported in source

    Myocardial infarction by coronary artery ligation
    Outcome group
    Heart function · Cardiovascular
    Studied dose
    Dose not stated · intramuscular injection of peptide-eluting microrodsAs given in this study (mouse).

    Source sentences

    Summary
    and delayed decompensation.
    1 context sentence
    Summary · context
    Peptide eluting microrods and empty microrods were delivered via intramuscular injection following coronary artery ligation in mice.
  4. 04AnimalAnimal study (in vivo)Efficacy outcome

    In mice after myocardial infarction, MGF E-domain peptide microrods were associated with inhibition of pathologic hypertrophy.

    In plain wordsIn mice after a heart attack, the MGF E-domain peptide in microrods was linked to less harmful heart enlargement.

    Peptide
    MGF / PEG-MGF
    Outcome
    DecreasePathologic hypertrophy
    Study

    mousen: not reported in source

    Myocardial infarction by coronary artery ligation
    Outcome group
    Heart function · Cardiovascular
    Studied dose
    Dose not stated · intramuscular injection of peptide-eluting microrodsAs given in this study (mouse).

    Source sentences

    Summary
    the inhibition of pathologic hypertrophy despite increasing vascular impedance.
    1 context sentence
    Summary · context
    Peptide eluting microrods and empty microrods were delivered via intramuscular injection following coronary artery ligation in mice.
  5. 05AnimalAnimal study (in vivo)Other

    In mice after myocardial infarction, vascular impedance increased with MGF E-domain peptide microrods.

    In plain wordsIn mice after a heart attack, vessel resistance rose with the MGF E-domain peptide in microrods.

    Peptide
    MGF / PEG-MGF
    Outcome
    IncreaseVascular impedance
    Study

    mousen: not reported in source

    Myocardial infarction by coronary artery ligation
    Outcome group
    Heart function · Cardiovascular
    Studied dose
    Dose not stated · intramuscular injection of peptide-eluting microrodsAs given in this study (mouse).

    Source sentences

    Summary
    despite increasing vascular impedance.
    1 context sentence
    Summary · context
    Peptide eluting microrods and empty microrods were delivered via intramuscular injection following coronary artery ligation in mice.

AI wrote and checked these results. AI can make mistakes, so check important results against the source.

Version history

PepBank keeps every version of the data on this study. Status changes from Retraction Watch, Europe PMC and Crossref are listed with their source.

  1. Version 2Current

    13 Oct 2026, 21:44 UTC

    Study results updated

  2. Version 1

    13 Oct 2026, 16:31 UTC

    First added · source update from Europe PMC

Subjects

Terms as the source lists them.

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