Growth hormone-releasing peptide-biotin conjugate stimulates myocytes differentiation through insulin-like growth factor-1 and collagen type I.

Lim CJ, Jeon JE, Jeong SK, Yoon SJ, Kwon SD, Lim J, Park K, Kim DY, Ahn JK, Kim BW

BMB reports1 Sept 2015Cited by 5 (Europe PMC)

PMID25644636PMCIDPMC4641233DOI10.5483/bmbrep.2015.48.9.258PepBankPUB-25644636

Read at source PubMedAsk about this study

Summary

The text of this summary is not shown here, because the article license does not allow reuse. Read it at the source (opens in a new tab)

Text rights: CC BY-NC. Results still quote short attributed sentences.

Results from this study8

No result from this study comes from a test of the peptide.

Studies that did not test the peptide alone8

In this study, GHRP-6 was a lab tool or a carrier, part of a mix, or the subject of a lab method. These results are not evidence about taking GHRP-6.

01LabNot a test of GHRP-6 aloneIn vitro (cells)Mechanism
In cultured myoblasts, the GHRP‑6-biotin conjugate increased expression of myogenic marker proteins.
In plain wordsIn cells, the GHRP‑6-biotin conjugate increased muscle development marker proteins.
Peptide
GHRP-6
Outcome
IncreaseMyogenic marker expression
Study
n: not reported in source
Cultured myoblast cells
Outcome group
Muscle injury and repair · Musculoskeletal
Source sentences
Summary
Increased expression of myogenic marker proteins was observed in GHRP-6-biotin conjugate-treated cells.
1 context sentence(design, population, supporting numbers)
Summary · context
Based on the potential beneficial effects of growth hormone releasing peptide (GHRP)-6 on muscle functions, a newly synthesized GHRP-6-biotin conjugate was tested on cultured myoblast cells.
In this study, GHRP-6 was a lab tool or a carrier, part of a mix, or the subject of a lab method. This result is not evidence about taking GHRP-6.
Report a problemFND-2564463601
02LabNot a test of GHRP-6 aloneIn vitro (cells)Mechanism
In cultured myoblasts, the GHRP‑6-biotin conjugate increased IGF-1 expression.
In plain wordsIn cells, the GHRP‑6-biotin conjugate increased IGF-1 expression.
Peptide
GHRP-6
Outcome
IncreaseIGF-1 expression
Study
n: not reported in source
Cultured myoblast cells
Outcome group
Muscle injury and repair · Musculoskeletal
Source sentences
Summary
Additionally, increased expression levels of insulin-like growth factor-1 and collagen type I were observed.
1 context sentence(design, population, supporting numbers)
Summary · context
Based on the potential beneficial effects of growth hormone releasing peptide (GHRP)-6 on muscle functions, a newly synthesized GHRP-6-biotin conjugate was tested on cultured myoblast cells.
In this study, GHRP-6 was a lab tool or a carrier, part of a mix, or the subject of a lab method. This result is not evidence about taking GHRP-6.
Report a problemFND-2564463602
03LabNot a test of GHRP-6 aloneIn vitro (cells)Mechanism
In cultured myoblasts, the GHRP‑6-biotin conjugate increased collagen type I expression.
In plain wordsIn cells, the GHRP‑6-biotin conjugate increased collagen type I expression.
Peptide
GHRP-6
Outcome
IncreaseCollagen type I expression
Study
n: not reported in source
Cultured myoblast cells
Outcome group
Muscle injury and repair · Musculoskeletal
Source sentences
Summary
Additionally, increased expression levels of insulin-like growth factor-1 and collagen type I were observed.
1 context sentence(design, population, supporting numbers)
Summary · context
Based on the potential beneficial effects of growth hormone releasing peptide (GHRP)-6 on muscle functions, a newly synthesized GHRP-6-biotin conjugate was tested on cultured myoblast cells.
In this study, GHRP-6 was a lab tool or a carrier, part of a mix, or the subject of a lab method. This result is not evidence about taking GHRP-6.
Report a problemFND-2564463603
04LabNot a test of GHRP-6 aloneIn vitro (cells)Mechanism
In cultured myoblasts, the GHRP‑6-biotin conjugate increased ATP concentration.
In plain wordsIn cells, the GHRP‑6-biotin conjugate increased ATP levels.
Peptide
GHRP-6
Outcome
IncreaseATP concentration
Study
n: not reported in source
Cultured myoblast cells
Outcome group
Muscle injury and repair · Musculoskeletal
Source sentences
Summary
Furthermore, GHRP-6-biotin conjugate-treated cells showed increased metabolic activity, as indicated by increased concentrations of energy metabolites, such as ATP and lactate, and increased enzymatic activity of lactate dehydrogenase and creatine kinase.
1 context sentence(design, population, supporting numbers)
Summary · context
Based on the potential beneficial effects of growth hormone releasing peptide (GHRP)-6 on muscle functions, a newly synthesized GHRP-6-biotin conjugate was tested on cultured myoblast cells.
In this study, GHRP-6 was a lab tool or a carrier, part of a mix, or the subject of a lab method. This result is not evidence about taking GHRP-6.
Report a problemFND-2564463604
05LabNot a test of GHRP-6 aloneIn vitro (cells)Mechanism
In cultured myoblasts, the GHRP‑6-biotin conjugate increased lactate concentration.
In plain wordsIn cells, the GHRP‑6-biotin conjugate increased lactate levels.
Peptide
GHRP-6
Outcome
IncreaseLactate concentration
Study
n: not reported in source
Cultured myoblast cells
Outcome group
Muscle injury and repair · Musculoskeletal
Source sentences
Summary
Furthermore, GHRP-6-biotin conjugate-treated cells showed increased metabolic activity, as indicated by increased concentrations of energy metabolites, such as ATP and lactate, and increased enzymatic activity of lactate dehydrogenase and creatine kinase.
1 context sentence(design, population, supporting numbers)
Summary · context
Based on the potential beneficial effects of growth hormone releasing peptide (GHRP)-6 on muscle functions, a newly synthesized GHRP-6-biotin conjugate was tested on cultured myoblast cells.
In this study, GHRP-6 was a lab tool or a carrier, part of a mix, or the subject of a lab method. This result is not evidence about taking GHRP-6.
Report a problemFND-2564463605
06LabNot a test of GHRP-6 aloneIn vitro (cells)Mechanism
In cultured myoblasts, the GHRP‑6-biotin conjugate increased lactate dehydrogenase activity.
In plain wordsIn cells, the GHRP‑6-biotin conjugate increased lactate dehydrogenase activity.
Peptide
GHRP-6
Outcome
IncreaseLactate dehydrogenase activity
Study
n: not reported in source
Cultured myoblast cells
Outcome group
Muscle injury and repair · Musculoskeletal
Source sentences
Summary
Furthermore, GHRP-6-biotin conjugate-treated cells showed increased metabolic activity, as indicated by increased concentrations of energy metabolites, such as ATP and lactate, and increased enzymatic activity of lactate dehydrogenase and creatine kinase.
1 context sentence(design, population, supporting numbers)
Summary · context
Based on the potential beneficial effects of growth hormone releasing peptide (GHRP)-6 on muscle functions, a newly synthesized GHRP-6-biotin conjugate was tested on cultured myoblast cells.
In this study, GHRP-6 was a lab tool or a carrier, part of a mix, or the subject of a lab method. This result is not evidence about taking GHRP-6.
Report a problemFND-2564463606
07LabNot a test of GHRP-6 aloneIn vitro (cells)Mechanism
In cultured myoblasts, the GHRP‑6-biotin conjugate increased creatine kinase activity.
In plain wordsIn cells, the GHRP‑6-biotin conjugate increased creatine kinase activity.
Peptide
GHRP-6
Outcome
IncreaseCreatine kinase activity
Study
n: not reported in source
Cultured myoblast cells
Outcome group
Muscle injury and repair · Musculoskeletal
Source sentences
Summary
Furthermore, GHRP-6-biotin conjugate-treated cells showed increased metabolic activity, as indicated by increased concentrations of energy metabolites, such as ATP and lactate, and increased enzymatic activity of lactate dehydrogenase and creatine kinase.
1 context sentence(design, population, supporting numbers)
Summary · context
Based on the potential beneficial effects of growth hormone releasing peptide (GHRP)-6 on muscle functions, a newly synthesized GHRP-6-biotin conjugate was tested on cultured myoblast cells.
In this study, GHRP-6 was a lab tool or a carrier, part of a mix, or the subject of a lab method. This result is not evidence about taking GHRP-6.
Report a problemFND-2564463607
08LabNot a test of GHRP-6 aloneIn vitro (cells)Mechanism
In myoblast experiments, binding analysis suggested desmin, actin, and zinc finger protein 691 as potential GHRP‑6-biotin conjugate targets.
In plain wordsIn cells, binding analysis suggested several possible protein targets for the GHRP‑6-biotin conjugate.
Peptide
GHRP-6
Outcome
Not applicableCandidate binding targets
Study
n: not reported in source
Cultured myoblast cells
Outcome group
Receptor activity and mechanism · Musculoskeletal
Source sentences
Summary
Finally, binding protein analysis suggested few candidate proteins, including desmin, actin, and zinc finger protein 691 as potential targets for GHRP6-biotin conjugate action.
1 context sentence(design, population, supporting numbers)
Summary · context
Based on the potential beneficial effects of growth hormone releasing peptide (GHRP)-6 on muscle functions, a newly synthesized GHRP-6-biotin conjugate was tested on cultured myoblast cells.
In this study, GHRP-6 was a lab tool or a carrier, part of a mix, or the subject of a lab method. This result is not evidence about taking GHRP-6.
Report a problemFND-2564463608

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Version history

PepBank keeps every version of the data on this study. Status changes from Retraction Watch, Europe PMC and Crossref are listed with their source.

Version 2Current
21 Oct 2026, 15:58 UTC
Study results updated
Version 1
9 Oct 2026, 03:13 UTC
First added · source update from Europe PMC

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