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Study · Randomized controlled trial · n = 34 · 2015

4 results

Oxytocin administration selectively improves olfactory detection thresholds for lyral in patients with schizophrenia.

Woolley JD, Lam O, Chuang B, Ford JM, Mathalon DH, Vinogradov S

Psychoneuroendocrinology7 Jan 2015Cited by 12 (Europe PMC)

PMID25637811 (opens in a new tab)PMCIDPMC4503321 (opens in a new tab)DOI10.1016/j.psyneuen.2014.12.018 (opens in a new tab)PepBankPUB-25637811
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Summary

The text of this summary is not shown here, because the article license does not allow reuse. Read it at the source (opens in a new tab)

Text rights: Publisher copyright. Results still quote short attributed sentences.

Results from this study4

4 results from studies that gave the peptide. 4 results from people.

  1. 01HumanRandomized controlled trialEfficacy outcome

    In healthy controls, oxytocin had no effect on detection of lyral.

    In plain wordsIn healthy people, oxytocin nasal spray did not change the sense of smell for lyral compared with placebo.

    Peptide
    Oxytocin
    Outcome
    No significant changeOlfactory detection threshold for lyral, healthy controls
    Study

    n = 34

    Comparator
    Placebo
    Outcome group
    Sensory perception · Nervous system and cognition
    Studied dose
    40 IU · intranasalAs given in this study (human).

    Source sentences

    Summary
    In contrast, oxytocin had no effect on detection of either odor in healthy controls.
    1 context sentence
    Summary · context
    To examine this model, we administered 40IU of oxytocin and placebo intranasally to 31 patients with a schizophrenia spectrum illness and 34 age-matched healthy control participants in a randomized, double-blind, placebo-controlled, cross-over study.
  2. 02HumanRandomized controlled trialEfficacy outcome

    In healthy controls, oxytocin had no effect on detection of anise.

    In plain wordsIn healthy people, oxytocin nasal spray did not change the sense of smell for anise compared with placebo.

    Peptide
    Oxytocin
    Outcome
    No significant changeOlfactory detection threshold for anise, healthy controls
    Study

    n = 34

    Comparator
    Placebo
    Outcome group
    Sensory perception · Nervous system and cognition
    Studied dose
    40 IU · intranasalAs given in this study (human).

    Source sentences

    Summary
    In contrast, oxytocin had no effect on detection of either odor in healthy controls.
    1 context sentence
    Summary · context
    To examine this model, we administered 40IU of oxytocin and placebo intranasally to 31 patients with a schizophrenia spectrum illness and 34 age-matched healthy control participants in a randomized, double-blind, placebo-controlled, cross-over study.
  3. 03HumanRandomized controlled trialEfficacy outcome

    In patients with a schizophrenia spectrum illness, oxytocin significantly improved olfactory detection thresholds for lyral.

    In plain wordsIn people with schizophrenia, oxytocin nasal spray improved the sense of smell for one odor (lyral) compared with placebo.

    Peptide
    Oxytocin
    Outcome
    IncreaseOlfactory detection threshold for lyral, patients with schizophrenia
    Study

    n = 31

    Comparator
    Placebo
    Outcome group
    Sensory perception · Nervous system and cognition
    Studied dose
    40 IU · intranasalAs given in this study (human).

    Source sentences

    Summary
    We found that oxytocin administration significantly and selectively improved olfactory detection thresholds for lyral but not for anise in patients with schizophrenia.
    1 context sentence
    Summary · context
    To examine this model, we administered 40IU of oxytocin and placebo intranasally to 31 patients with a schizophrenia spectrum illness and 34 age-matched healthy control participants in a randomized, double-blind, placebo-controlled, cross-over study.
  4. 04HumanRandomized controlled trialEfficacy outcome

    In patients with a schizophrenia spectrum illness, oxytocin did not improve olfactory detection thresholds for anise.

    In plain wordsIn people with schizophrenia, oxytocin nasal spray did not improve the sense of smell for anise compared with placebo.

    Peptide
    Oxytocin
    Outcome
    No significant changeOlfactory detection threshold for anise, patients with schizophrenia
    Study

    n = 31

    Comparator
    Placebo
    Outcome group
    Sensory perception · Nervous system and cognition
    Studied dose
    40 IU · intranasalAs given in this study (human).

    Source sentences

    Summary
    We found that oxytocin administration significantly and selectively improved olfactory detection thresholds for lyral but not for anise in patients with schizophrenia.
    1 context sentence
    Summary · context
    To examine this model, we administered 40IU of oxytocin and placebo intranasally to 31 patients with a schizophrenia spectrum illness and 34 age-matched healthy control participants in a randomized, double-blind, placebo-controlled, cross-over study.

AI wrote and checked these results. AI can make mistakes, so check important results against the source.

Version history

PepBank keeps every version of the data on this study. Status changes from Retraction Watch, Europe PMC and Crossref are listed with their source.

  1. Version 2Current

    11 Oct 2026, 01:30 UTC

    Study results updated

  2. Version 1

    9 Oct 2026, 02:49 UTC

    First added · source update from Europe PMC

Subjects

Terms as the source lists them.

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