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Study · Animal study (in vivo) · rat · 2015

7 results

Cerebrolysin improves cognitive performance in rats after mild traumatic brain injury.

Zhang Y, Chopp M, Meng Y, Zhang ZG, Doppler E, Winter S, Schallert T, Mahmood A, Xiong Y

Journal of neurosurgery23 Jan 2015Cited by 45 (Europe PMC)

PMID25614944 (opens in a new tab)DOI10.3171/2014.11.jns14271 (opens in a new tab)PepBankPUB-25614944
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Summary

The text of this summary is not shown here, because the article license does not allow reuse. Read it at the source (opens in a new tab)

Text rights: Publisher copyright. Results still quote short attributed sentences.

Results from this study7

7 results from studies that gave the peptide. No result from this study comes from people.

  1. 01AnimalAnimal study (in vivo)Efficacy outcome

    In rats after mild traumatic brain injury, cerebrolysin improved long-term spatial learning versus saline up to 90 days after injury.

    In plain wordsIn rats after mild brain injury, cerebrolysin improved spatial learning compared with saline.

    Peptide
    Cerebrolysin
    Outcome
    IncreaseSpatial learning
    Study

    ratn = 22

    Closed-head mild traumatic brain injury
    Comparator
    Saline
    Outcome group
    Cognition and memory · Nervous system and cognition
    Studied dose
    2.5 ml/kg · 28 daysAs given in this study (rat).

    Source sentences

    Summary
    Compared with saline treatment, Cerebrolysin treatment significantly improved both long-term spatial learning and memory in the MWM test and nonspatial recognition memory in the social odor recognition task up to 90 days after mTBI (p < 0.05).
    1 context sentence
    Summary · context
    Rats subjected to closed-head mTBI were treated with saline (n = 11) or Cerebrolysin (2.5 ml/kg, n = 11) starting 24 hours after injury and then daily for 28 days.
  2. 02AnimalAnimal study (in vivo)Efficacy outcome

    In rats after mild traumatic brain injury, cerebrolysin improved long-term spatial memory versus saline up to 90 days after injury.

    In plain wordsIn rats after mild brain injury, cerebrolysin improved spatial memory compared with saline.

    Peptide
    Cerebrolysin
    Outcome
    IncreaseSpatial memory
    Study

    ratn = 22

    Closed-head mild traumatic brain injury
    Comparator
    Saline
    Outcome group
    Cognition and memory · Nervous system and cognition
    Studied dose
    2.5 ml/kg · 28 daysAs given in this study (rat).

    Source sentences

    Summary
    Compared with saline treatment, Cerebrolysin treatment significantly improved both long-term spatial learning and memory in the MWM test and nonspatial recognition memory in the social odor recognition task up to 90 days after mTBI (p < 0.05).
    1 context sentence
    Summary · context
    Rats subjected to closed-head mTBI were treated with saline (n = 11) or Cerebrolysin (2.5 ml/kg, n = 11) starting 24 hours after injury and then daily for 28 days.
  3. 03AnimalAnimal study (in vivo)Efficacy outcome

    In rats after mild traumatic brain injury, cerebrolysin improved nonspatial recognition memory versus saline up to 90 days after injury.

    In plain wordsIn rats after mild brain injury, cerebrolysin improved nonspatial recognition memory compared with saline.

    Peptide
    Cerebrolysin
    Outcome
    IncreaseNonspatial recognition memory
    Study

    ratn = 22

    Closed-head mild traumatic brain injury
    Comparator
    Saline
    Outcome group
    Cognition and memory · Nervous system and cognition
    Studied dose
    2.5 ml/kg · 28 daysAs given in this study (rat).

    Source sentences

    Summary
    Compared with saline treatment, Cerebrolysin treatment significantly improved both long-term spatial learning and memory in the MWM test and nonspatial recognition memory in the social odor recognition task up to 90 days after mTBI (p < 0.05).
    1 context sentence
    Summary · context
    Rats subjected to closed-head mTBI were treated with saline (n = 11) or Cerebrolysin (2.5 ml/kg, n = 11) starting 24 hours after injury and then daily for 28 days.
  4. 04AnimalAnimal study (in vivo)Efficacy outcome

    In rats after mild traumatic brain injury, cerebrolysin increased neuroblast numbers in the dentate gyrus versus saline.

    In plain wordsIn rats after mild brain injury, cerebrolysin increased neuroblast numbers compared with saline.

    Peptide
    Cerebrolysin
    Outcome
    IncreaseNeuroblast number
    Study

    ratn = 22

    Closed-head mild traumatic brain injury
    Comparator
    Saline
    Outcome group
    Neuroprotection · Nervous system and cognition
    Studied dose
    2.5 ml/kg · 28 daysAs given in this study (rat).

    Source sentences

    Summary
    Cerebrolysin significantly increased the number of neuroblasts and promoted neurogenesis in the dentate gyrus, and it reduced APP levels and astrogliosis in the corpus callosum, cortex, dentate gyrus, CA1, and CA3 regions (p < 0.05).
    1 context sentence
    Summary · context
    Rats subjected to closed-head mTBI were treated with saline (n = 11) or Cerebrolysin (2.5 ml/kg, n = 11) starting 24 hours after injury and then daily for 28 days.
  5. 05AnimalAnimal study (in vivo)Efficacy outcome

    In rats after mild traumatic brain injury, cerebrolysin promoted dentate gyrus neurogenesis versus saline.

    In plain wordsIn rats after mild brain injury, cerebrolysin increased new neuron formation compared with saline.

    Peptide
    Cerebrolysin
    Outcome
    IncreaseNeurogenesis
    Study

    ratn = 22

    Closed-head mild traumatic brain injury
    Comparator
    Saline
    Outcome group
    Neuroprotection · Nervous system and cognition
    Studied dose
    2.5 ml/kg · 28 daysAs given in this study (rat).

    Source sentences

    Summary
    Cerebrolysin significantly increased the number of neuroblasts and promoted neurogenesis in the dentate gyrus, and it reduced APP levels and astrogliosis in the corpus callosum, cortex, dentate gyrus, CA1, and CA3 regions (p < 0.05).
    1 context sentence
    Summary · context
    Rats subjected to closed-head mTBI were treated with saline (n = 11) or Cerebrolysin (2.5 ml/kg, n = 11) starting 24 hours after injury and then daily for 28 days.
  6. 06AnimalAnimal study (in vivo)Efficacy outcome

    In rats after mild traumatic brain injury, cerebrolysin reduced APP levels in the reported brain regions versus saline.

    In plain wordsIn rats after mild brain injury, cerebrolysin reduced brain APP levels compared with saline.

    Peptide
    Cerebrolysin
    Outcome
    DecreaseAPP levels
    Study

    ratn = 22

    Closed-head mild traumatic brain injury
    Comparator
    Saline
    Outcome group
    Neuroprotection · Nervous system and cognition
    Studied dose
    2.5 ml/kg · 28 daysAs given in this study (rat).

    Source sentences

    Summary
    Cerebrolysin significantly increased the number of neuroblasts and promoted neurogenesis in the dentate gyrus, and it reduced APP levels and astrogliosis in the corpus callosum, cortex, dentate gyrus, CA1, and CA3 regions (p < 0.05).
    1 context sentence
    Summary · context
    Rats subjected to closed-head mTBI were treated with saline (n = 11) or Cerebrolysin (2.5 ml/kg, n = 11) starting 24 hours after injury and then daily for 28 days.
  7. 07AnimalAnimal study (in vivo)Efficacy outcome

    In rats after mild traumatic brain injury, cerebrolysin reduced astrogliosis in the reported brain regions versus saline.

    In plain wordsIn rats after mild brain injury, cerebrolysin reduced astrogliosis compared with saline.

    Peptide
    Cerebrolysin
    Outcome
    DecreaseAstrogliosis
    Study

    ratn = 22

    Closed-head mild traumatic brain injury
    Comparator
    Saline
    Outcome group
    Neuroprotection · Nervous system and cognition
    Studied dose
    2.5 ml/kg · 28 daysAs given in this study (rat).

    Source sentences

    Summary
    Cerebrolysin significantly increased the number of neuroblasts and promoted neurogenesis in the dentate gyrus, and it reduced APP levels and astrogliosis in the corpus callosum, cortex, dentate gyrus, CA1, and CA3 regions (p < 0.05).
    1 context sentence
    Summary · context
    Rats subjected to closed-head mTBI were treated with saline (n = 11) or Cerebrolysin (2.5 ml/kg, n = 11) starting 24 hours after injury and then daily for 28 days.

AI wrote and checked these results. AI can make mistakes, so check important results against the source.

Version history

PepBank keeps every version of the data on this study. Status changes from Retraction Watch, Europe PMC and Crossref are listed with their source.

  1. Version 2Current

    14 Oct 2026, 05:02 UTC

    Study results updated

  2. Version 1

    14 Oct 2026, 01:46 UTC

    First added · source update from Europe PMC

Subjects

Terms as the source lists them.

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