Nonverbal communication of patients with borderline personality disorder during clinical interviews: a double-blind placebo-controlled study using intranasal oxytocin.

Brüne M, Kolb M, Ebert A, Roser P, Edel MA

The Journal of nervous and mental disease1 Feb 2015Cited by 24 (Europe PMC)

PMID25594788DOI10.1097/nmd.0000000000000240PepBankPUB-25594788

Publisher page PubMedAsk about this study

Summary

The text of this summary is not shown here, because the article license does not allow reuse. Read it at the source (opens in a new tab)

Text rights: Publisher copyright. Results still quote short attributed sentences.

Results from this study4

4 results from studies that gave the peptide. 4 results from people.

01HumanRandomized controlled trialEfficacy outcome
In patients with borderline personality disorder and in controls, oxytocin given at T1 was associated with less flight behavior than placebo.
In plain wordsIn people with borderline personality disorder and in controls, oxytocin was linked to less withdrawing behavior than placebo when given first.
Peptide
Oxytocin
Outcome
DecreaseFlight behavior
Study
n = 30
Comparator
Placebo
Outcome group
Social behavior and cognition · Mental health and mood
Studied dose
Dose not stated · intranasalAs given in this study (human).
Source sentences
Summary
OT was also associated with less flight behavior in both groups when given at T1 compared with placebo.
2 context sentences(design, population, supporting numbers)
Summary · context
Fifteen BPD patients and 15 controls participated in two clinical interviews, one under OT and one under placebo, which were randomly conducted 1 week apart in a double-blind fashion.
Title · context
Nonverbal communication of patients with borderline personality disorder during clinical interviews: a double-blind placebo-controlled study using intranasal oxytocin.
Report a problemFND-2559478803
02HumanRandomized controlled trialEfficacy outcome
In healthy controls, affiliative behavior was higher when oxytocin was given at T1 than when oxytocin was given at T2.
In plain wordsIn healthy controls, people showed more friendly behavior when oxytocin came first than when it came second.
Peptide
Oxytocin
Outcome
IncreaseAffiliative behavior, oxytocin at T1 versus T2, controls
Study
n = 15
Comparator
Oxytocin given at T2
Outcome group
Social behavior and cognition · Mental health and mood
Studied dose
Dose not stated · intranasalAs given in this study (human).
Source sentences
Summary
Notably, the controls, but not the patients, displayed more affiliation when OT was given at T1 compared with OT given at T2.
2 context sentences(design, population, supporting numbers)
Summary · context
Fifteen BPD patients and 15 controls participated in two clinical interviews, one under OT and one under placebo, which were randomly conducted 1 week apart in a double-blind fashion.
Title · context
Nonverbal communication of patients with borderline personality disorder during clinical interviews: a double-blind placebo-controlled study using intranasal oxytocin.
Report a problemFND-2559478801
03HumanRandomized controlled trialEfficacy outcome
In patients with borderline personality disorder, affiliative behavior did not differ between oxytocin given at T1 and oxytocin given at T2.
In plain wordsIn people with borderline personality disorder, friendly behavior did not change whether oxytocin came first or second.
Peptide
Oxytocin
Outcome
No significant changeAffiliative behavior, oxytocin at T1 versus T2, patients with BPD
Study
n = 15
Comparator
Oxytocin given at T2
Outcome group
Social behavior and cognition · Mental health and mood
Studied dose
Dose not stated · intranasalAs given in this study (human).
Source sentences
Summary
Notably, the controls, but not the patients, displayed more affiliation when OT was given at T1 compared with OT given at T2.
2 context sentences(design, population, supporting numbers)
Summary · context
Fifteen BPD patients and 15 controls participated in two clinical interviews, one under OT and one under placebo, which were randomly conducted 1 week apart in a double-blind fashion.
Title · context
Nonverbal communication of patients with borderline personality disorder during clinical interviews: a double-blind placebo-controlled study using intranasal oxytocin.
Report a problemFND-2559478802
04HumanRandomized controlled trialEfficacy outcome
In patients with borderline personality disorder, responses to oxytocin were unrelated to history of childhood trauma.
In plain wordsIn people with borderline personality disorder, how they responded to oxytocin was not related to childhood trauma.
Peptide
Oxytocin
Outcome
No significant changeOxytocin responses and childhood trauma history
Study
n = 15
Outcome group
Social behavior and cognition · Mental health and mood
Studied dose
Dose not stated · intranasalAs given in this study (human).
Source sentences
Summary
OT responses were unrelated to the patients' history of childhood trauma.
2 context sentences(design, population, supporting numbers)
Summary · context
Fifteen BPD patients and 15 controls participated in two clinical interviews, one under OT and one under placebo, which were randomly conducted 1 week apart in a double-blind fashion.
Title · context
Nonverbal communication of patients with borderline personality disorder during clinical interviews: a double-blind placebo-controlled study using intranasal oxytocin.
Report a problemFND-2559478804

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Version history

PepBank keeps every version of the data on this study. Status changes from Retraction Watch, Europe PMC and Crossref are listed with their source.

Version 2Current
11 Oct 2026, 01:30 UTC
Study results updated
Version 1
9 Oct 2026, 02:50 UTC
First added · source update from Europe PMC

Subjects

Terms as the source lists them.

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MeSH terms

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