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Study · Ex vivo tissue · rat · 2015

4 results

Nootropic dipeptide noopept enhances inhibitory synaptic transmission in the hippocampus.

Povarov IS, Kondratenko RV, Derevyagin VI, Ostrovskaya RU, Skrebitskii VG

Bulletin of experimental biology and medicine9 Jan 2015Cited by 1 (Europe PMC)

PMID25573367 (opens in a new tab)DOI10.1007/s10517-015-2759-2 (opens in a new tab)PepBankPUB-25573367
Publisher pagePubMedAsk about this study
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Summary

The text of this summary is not shown here, because the article license does not allow reuse. Read it at the source (opens in a new tab)

Text rights: Publisher copyright. Results still quote short attributed sentences.

Results from this study4

4 results from studies that gave the peptide. No result from this study comes from people.

  1. 01LabEx vivo tissueMechanism

    In rat hippocampal slices, Noopept enhanced the inhibitory component of stimulation-induced current in CA1 pyramidal neurons.

    In plain wordsIn lab tests on rat hippocampal slices, Noopept increased inhibitory synaptic current.

    Peptide
    Noopept (omberacetam)
    Outcome
    IncreaseInhibitory synaptic current
    Study

    ratn: not reported in source

    Wistar rat hippocampal slices
    Outcome group
    Receptor activity and mechanism · Nervous system and cognition
    Studied dose
    Dose not stated

    Source sentences

    Summary
    Application of nootropic agent Noopept on hippocampal slices from Wistar rats enhanced the inhibitory component of total current induced by stimulation of Shaffer collaterals in CA1 pyramidal neurons, but did not affect the excitatory component.
  2. 02LabEx vivo tissueMechanism

    In rat hippocampal slices, Noopept did not affect the excitatory component of stimulation-induced current.

    In plain wordsIn lab tests on rat hippocampal slices, Noopept did not change excitatory synaptic current.

    Peptide
    Noopept (omberacetam)
    Outcome
    No significant changeExcitatory synaptic current
    Study

    ratn: not reported in source

    Wistar rat hippocampal slices
    Outcome group
    Receptor activity and mechanism · Nervous system and cognition
    Studied dose
    Dose not stated

    Source sentences

    Summary
    Application of nootropic agent Noopept on hippocampal slices from Wistar rats enhanced the inhibitory component of total current induced by stimulation of Shaffer collaterals in CA1 pyramidal neurons, but did not affect the excitatory component.
  3. 03LabEx vivo tissueMechanism

    In rat hippocampal slices, inhibitory current amplitude increases correlated directly with Noopept concentration.

    In plain wordsIn lab tests on rat hippocampal slices, higher Noopept concentrations correlated with larger increases in inhibitory current.

    Peptide
    Noopept (omberacetam)
    Outcome
    IncreaseInhibitory current concentration dependence
    Study

    ratn: not reported in source

    Wistar rat hippocampal slices
    Outcome group
    Receptor activity and mechanism · Nervous system and cognition
    Studied dose
    Dose not stated

    Source sentences

    Summary
    A direct correlation between the increase in the amplitude of inhibitory current and agent concentration was found.
  4. 04LabEx vivo tissueMechanism

    In rat hippocampal slices, Noopept did not affect inhibitory transmitter release from terminals in pyramidal neurons.

    In plain wordsIn lab tests on rat hippocampal slices, Noopept did not change inhibitory transmitter release from terminals in pyramidal neurons.

    Peptide
    Noopept (omberacetam)
    Outcome
    No significant changeInhibitory transmitter release
    Study

    ratn: not reported in source

    Wistar rat hippocampal slices
    Outcome group
    Receptor activity and mechanism · Nervous system and cognition
    Studied dose
    Dose not stated

    Source sentences

    Summary
    The substance did not affect the release of inhibitory transmitters from terminals in the pyramidal neurons, which indicated changes in GABAergic interneurons.

AI wrote and checked these results. AI can make mistakes, so check important results against the source.

Version history

PepBank keeps every version of the data on this study. Status changes from Retraction Watch, Europe PMC and Crossref are listed with their source.

  1. Version 2Current

    21 Oct 2026, 15:58 UTC

    Study results updated

  2. Version 1

    21 Oct 2026, 12:50 UTC

    First added · source update from Europe PMC

Subjects

Terms as the source lists them.

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