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Study · Not a test of the peptide alone · 2014

3 results

[The impact of immunoactive drugs on passive avoidance response].

Novoseletskaia AV, Kiseleva NM, Belova OV, Zimina IV, Moskvina SN, Bystrova OV, Inozemtsev AN, Arion VIa, Sergienko VI

Vestnik Rossiiskoi akademii meditsinskikh nauk1 Jan 2014

PMID25563001 (opens in a new tab)DOI10.15690/vramn.v69i7-8.1106 (opens in a new tab)PepBankPUB-25563001
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Summary

The text of this summary is not shown here, because the article license does not allow reuse. Read it at the source (opens in a new tab)

Text rights: Publisher copyright. Results still quote short attributed sentences.

Results from this study3

No result from this study comes from a test of the peptide.

Studies that did not test the peptide alone3

In this study, Thymulin (serum thymic factor) was a lab tool or a carrier, part of a mix, or the subject of a lab method. These results are not evidence about taking Thymulin (serum thymic factor).

  1. 01AnimalNot a test of Thymulin (serum thymic factor) aloneAnimal study (in vivo)Efficacy outcome

    In rats, immunoactive drugs including thymulin prolonged memory trace persistence in both avoidance models.

    In plain wordsIn rats, drugs including thymulin prolonged memory retention in both avoidance models.

    Peptide
    Thymulin (serum thymic factor)
    Outcome
    IncreaseMemory trace persistence
    Study

    ratn: not reported in source

    Passive avoidance box models
    Outcome group
    Cognition and memory · Nervous system and cognition

    Source sentences

    Summary
    The project has established that the memory trace persists longer under the influence of the immunoactive drugs in both models, which is consistent with the reference nootropic piracetam test results.
    2 context sentences
    Summary · context
    The objective of this project was to explore the influence of immunoactive drugs (tactivin, thymulin, and thymosin fraction 5) on the development of the passive avoidance conditioned reflex.
    Summary · context
    Two types of passive avoidance boxes were used--a regular two-chamber box and a modified three-chamber box, comprising a dark chamber in which rats were exposed to electrical shock, a safe dark chamber, and a light chamber in the center.

    In this study, Thymulin (serum thymic factor) was a lab tool or a carrier, part of a mix, or the subject of a lab method. This result is not evidence about taking Thymulin (serum thymic factor).

  2. 02AnimalNot a test of Thymulin (serum thymic factor) aloneAnimal study (in vivo)Efficacy outcome

    In rats, the pooled drugs' memory effect was stronger in the modified three-chamber box than in the standard box.

    In plain wordsIn rats, drugs including thymulin had stronger memory effects in the modified box than in the standard box.

    Peptide
    Thymulin (serum thymic factor)
    Outcome
    IncreaseModel-dependent memory effect
    Study

    ratn: not reported in source

    Passive avoidance box models
    Comparator
    Standard two-chamber box
    Outcome group
    Cognition and memory · Nervous system and cognition

    Source sentences

    Summary
    Notably, the immunoactive drugs' mnemotropic effect was more pronounced in the modified three-chamber box than in the standard two-chamber box.
    2 context sentences
    Summary · context
    The objective of this project was to explore the influence of immunoactive drugs (tactivin, thymulin, and thymosin fraction 5) on the development of the passive avoidance conditioned reflex.
    Summary · context
    Two types of passive avoidance boxes were used--a regular two-chamber box and a modified three-chamber box, comprising a dark chamber in which rats were exposed to electrical shock, a safe dark chamber, and a light chamber in the center.

    In this study, Thymulin (serum thymic factor) was a lab tool or a carrier, part of a mix, or the subject of a lab method. This result is not evidence about taking Thymulin (serum thymic factor).

  3. 03AnimalNot a test of Thymulin (serum thymic factor) aloneAnimal study (in vivo)Efficacy outcome

    In rats, thymus preparations including thymulin led to safe-chamber selection at later tests.

    In plain wordsIn rats, thymus preparations including thymulin led animals to select the safe chamber in later tests.

    Peptide
    Thymulin (serum thymic factor)
    Outcome
    Not applicableSafe chamber selection
    Study

    ratn: not reported in source

    Passive avoidance box models
    Outcome group
    Cognition and memory · Nervous system and cognition

    Source sentences

    Summary
    Immunotropic preparations from thymus caused the animals to select the safe chamber 24 hours later and in subsequent tests.
    2 context sentences
    Summary · context
    The objective of this project was to explore the influence of immunoactive drugs (tactivin, thymulin, and thymosin fraction 5) on the development of the passive avoidance conditioned reflex.
    Summary · context
    Two types of passive avoidance boxes were used--a regular two-chamber box and a modified three-chamber box, comprising a dark chamber in which rats were exposed to electrical shock, a safe dark chamber, and a light chamber in the center.

    In this study, Thymulin (serum thymic factor) was a lab tool or a carrier, part of a mix, or the subject of a lab method. This result is not evidence about taking Thymulin (serum thymic factor).

AI wrote and checked these results. AI can make mistakes, so check important results against the source.

Version history

PepBank keeps every version of the data on this study. Status changes from Retraction Watch, Europe PMC and Crossref are listed with their source.

  1. Version 3Current

    21 Oct 2026, 15:58 UTC

    Study results updated

  2. Version 2

    21 Oct 2026, 13:55 UTC

    Study data updated · source update from Europe PMC

  3. Version 1

    21 Oct 2026, 12:50 UTC

    First added · source update from Europe PMC

Subjects

Terms as the source lists them.

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