In healthy men, intranasal oxytocin given after fear conditioning increased electrodermal responses to conditioned fear in the early phase of extinction.
In plain wordsIn healthy men, oxytocin nasal spray raised skin responses to a learned fear cue early in extinction compared with placebo.
- Peptide
- Oxytocin
- Outcome
- IncreaseElectrodermal responses to conditioned fear, early extinction
- Study
n = 62
- Comparator
- Placebo
- Outcome group
- Anxiety and mood · Mental health and mood
- Studied dose
- 24 IU · intranasalAs given in this study (human).
Source sentences
Oxytocin, when administered intranasally after Pavlovian fear conditioning, was found to increase electrodermal responses and prefrontal cortex signals to conditioned fear in the early phase of extinction and to enhance the decline of skin conductance responses in the late phase of extinction.
2 context sentences(design, population, supporting numbers)
To address the question whether oxytocin can strengthen Pavlovian extinction beyond its role in controlling social fear, we conducted a functional magnetic resonance imaging experiment with 62 healthy male participants in a randomized, double-blind, parallel-group, placebo-controlled design.
Specifically, subjects were exposed to a Pavlovian fear conditioning paradigm before receiving an intranasal dose (24 IU) of synthetic oxytocin or placebo.