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Study · In vitro (cells) · pig · 2015

4 results

Oxytocin improves the expression of cardiac specific markers in porcine bone marrow stem cells differentiation.

Ybarra N, Vincent P, Smith LC, Troncy E

Research in veterinary science10 Dec 2014Cited by 5 (Europe PMC)

PMID25541154 (opens in a new tab)DOI10.1016/j.rvsc.2014.11.014 (opens in a new tab)PepBankPUB-25541154
Publisher pagePubMedAsk about this study
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Summary

The text of this summary is not shown here, because the article license does not allow reuse. Read it at the source (opens in a new tab)

Text rights: Publisher copyright. Results still quote short attributed sentences.

Results from this study4

4 results from studies that gave the peptide. No result from this study comes from people.

  1. 01LabIn vitro (cells)Mechanism

    In porcine bone marrow stem cells, oxytocin treatment upregulated GATA4 transcripts by RT-PCR, as did 5-azacytidine.

    In plain wordsIn pig stem cells in lab tests, oxytocin raised GATA4, a gene linked to heart muscle development.

    Peptide
    Oxytocin
    Outcome
    IncreaseGATA4 transcript expression
    Study

    pign: not reported in source

    porcine bone marrow stem cells (pBMSCs)
    Outcome group
    Receptor activity and mechanism · Cardiovascular
    Studied dose
    Dose not stated

    Source sentences

    Summary
    RT-PCR showed upregulation of GATA4 in OT and 5-azacytidine-induced groups.
    2 context sentences
    Summary · context
    We attempted to isolate, characterize, and induce OT-mediated cardiomyogenic differentiation of porcine pBMSCs.
    Summary · context
    Cells were treated as: control, OT, and 5-azacytidine groups.
  2. 02LabIn vitro (cells)Mechanism

    In porcine bone marrow stem cells, immunocytochemistry showed higher cardiac troponin T expression with oxytocin than with 5-azacytidine induction (p < 0.01).

    In plain wordsIn pig stem cells in lab tests, oxytocin raised a heart muscle protein more than 5-azacytidine did.

    Peptide
    Oxytocin
    Outcome
    IncreaseCardiac troponin T expression
    Study

    pign: not reported in source

    porcine bone marrow stem cells (pBMSCs)
    Comparator
    5-azacytidine
    Outcome group
    Receptor activity and mechanism · Cardiovascular
    Studied dose
    Dose not stated

    Source sentences

    Summary
    Immunocytochemistry revealed higher expressions of cardiac troponin T and myosin heavy chain in OT than in 5-azacytidine-induced groups (p < 0.01).
    2 context sentences
    Summary · context
    We attempted to isolate, characterize, and induce OT-mediated cardiomyogenic differentiation of porcine pBMSCs.
    Summary · context
    Cells were treated as: control, OT, and 5-azacytidine groups.
  3. 03LabIn vitro (cells)Mechanism

    In porcine bone marrow stem cells, immunocytochemistry showed higher myosin heavy chain expression with oxytocin than with 5-azacytidine induction (p < 0.01).

    In plain wordsIn pig stem cells in lab tests, oxytocin raised a heart muscle protein more than 5-azacytidine did.

    Peptide
    Oxytocin
    Outcome
    IncreaseMyosin heavy chain expression
    Study

    pign: not reported in source

    porcine bone marrow stem cells (pBMSCs)
    Comparator
    5-azacytidine
    Outcome group
    Receptor activity and mechanism · Cardiovascular
    Studied dose
    Dose not stated

    Source sentences

    Summary
    Immunocytochemistry revealed higher expressions of cardiac troponin T and myosin heavy chain in OT than in 5-azacytidine-induced groups (p < 0.01).
    2 context sentences
    Summary · context
    We attempted to isolate, characterize, and induce OT-mediated cardiomyogenic differentiation of porcine pBMSCs.
    Summary · context
    Cells were treated as: control, OT, and 5-azacytidine groups.
  4. 04LabIn vitro (cells)Mechanism

    In porcine bone marrow stem cells, Western blot showed upregulation of cardiac troponin I with oxytocin induction (p < 0.01).

    In plain wordsIn pig stem cells in lab tests, oxytocin raised a heart muscle protein called troponin I.

    Peptide
    Oxytocin
    Outcome
    IncreaseCardiac troponin I protein expression
    Study

    pign: not reported in source

    porcine bone marrow stem cells (pBMSCs)
    Outcome group
    Receptor activity and mechanism · Cardiovascular
    Studied dose
    Dose not stated

    Source sentences

    Summary
    Western blot analysis showed upregulation of cardiac troponin I in OT-induced pBMSCs (p < 0.01).
    2 context sentences
    Summary · context
    We attempted to isolate, characterize, and induce OT-mediated cardiomyogenic differentiation of porcine pBMSCs.
    Summary · context
    Cells were treated as: control, OT, and 5-azacytidine groups.

AI wrote and checked these results. AI can make mistakes, so check important results against the source.

Version history

PepBank keeps every version of the data on this study. Status changes from Retraction Watch, Europe PMC and Crossref are listed with their source.

  1. Version 2Current

    11 Oct 2026, 01:30 UTC

    Study results updated

  2. Version 1

    9 Oct 2026, 02:50 UTC

    First added · source update from Europe PMC

Subjects

Terms as the source lists them.

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