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Study · Animal study (in vivo) · horse · 2015

7 results

Oxytocin induction of pulses of a prostaglandin metabolite and luteolysis in mares.

Santos VG, Castro T, Bettencourt EM, Ginther OJ

Theriogenology13 Nov 2014Cited by 12 (Europe PMC)

PMID25523835 (opens in a new tab)DOI10.1016/j.theriogenology.2014.11.006 (opens in a new tab)PepBankPUB-25523835
Publisher pagePubMedAsk about this study
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Summary

The text of this summary is not shown here, because the article license does not allow reuse. Read it at the source (opens in a new tab)

Text rights: Publisher copyright. Results still quote short attributed sentences.

Results from this study7

6 results from studies that gave the peptide. No result from this study comes from people.

  1. 01AnimalAnimal study (in vivo)Activity measurement

    In mares, a 2-hour oxytocin infusion of 1.25, 2.5 or 5 IU/100 kg induced a PGFM pulse similar to reported pulses.

    In plain wordsIn mares, a 2-hour oxytocin drip caused a prostaglandin marker pulse like the natural one.

    Peptide
    Oxytocin
    Outcome
    IncreasePGFM pulse during 2-hour oxytocin infusion
    Study

    horsen = 4

    mares on Day 13 postovulation
    Outcome group
    Sex hormones and fertility · Reproductive and sexual health
    Studied dose
    1.25, 2.5 or 5 IU/100 kg · 2 hoursAs given in this study (horse).

    Source sentences

    Summary
    A 2-hour OT infusion of 1.25, 2.5, or 5 IU/100 kg (n = 4) induced a PGFM pulse similar to reported pulses
    1 context sentence
    Summary · context
    A procedure for oxytocin (OT) administration on Day 13 postovulation was developed in mares for stimulation of a pulse of PGFM (a PGF2α metabolite) that mimics a natural PGFM pulse during luteolysis.
  2. 02AnimalAnimal study (in vivo)Activity measurement

    In mares, a bolus of oxytocin at each of five doses stimulated a burst of PGFM that peaked in 4 minutes and was unlike a natural pulse.

    In plain wordsIn mares, a single oxytocin dose caused a fast burst of a prostaglandin marker that did not look like the natural pulse.

    Peptide
    Oxytocin
    Outcome
    IncreasePGFM response to oxytocin bolus
    Study

    horsen = 3

    mares on Day 13 postovulation
    Outcome group
    Sex hormones and fertility · Reproductive and sexual health
    Studied dose
    1-10 IU/mare · bolusAs given in this study (horse).

    Source sentences

    Summary
    Bolus treatment with each of five OT doses (1-10 IU/mare, n = 3) stimulated a burst of PGFM that was maximum in 4 minutes and was unlike a natural pulse.
    1 context sentence
    Summary · context
    A procedure for oxytocin (OT) administration on Day 13 postovulation was developed in mares for stimulation of a pulse of PGFM (a PGF2α metabolite) that mimics a natural PGFM pulse during luteolysis.
  3. 03AnimalAnimal study (in vivo)Activity measurement

    In mares, oxytocin infusion at doses lower than 1.25 IU/100 kg did not induce a PGFM pulse similar to reported pulses.

    In plain wordsIn mares, lower oxytocin drip doses did not cause a pulse like the natural one.

    Peptide
    Oxytocin
    Outcome
    No significant changePGFM pulse at lower oxytocin infusion doses
    Study

    horsen: not reported in source

    mares on Day 13 postovulation
    Outcome group
    Sex hormones and fertility · Reproductive and sexual health
    Studied dose
    Dose not stated · 2 hoursAs given in this study (horse).

    Source sentences

    Summary
    A 2-hour OT infusion of 1.25, 2.5, or 5 IU/100 kg (n = 4) induced a PGFM pulse similar to reported pulses; lower doses did not.
    1 context sentence
    Summary · context
    A procedure for oxytocin (OT) administration on Day 13 postovulation was developed in mares for stimulation of a pulse of PGFM (a PGF2α metabolite) that mimics a natural PGFM pulse during luteolysis.
  4. 04AnimalAnimal study (in vivo)Activity measurement

    In mares, the peak of the oxytocin-induced PGFM pulse was approximately 260-380 pg/mL, similar to reported natural peaks of approximately 200-300 pg/mL.

    In plain wordsIn mares, the peak of the oxytocin-induced prostaglandin marker pulse was close to the natural peak.

    Peptide
    Oxytocin
    Outcome
    Not applicablePeak of the induced PGFM pulse
    Study

    horsen: not reported in source

    mares on Day 13 postovulation
    Outcome group
    Sex hormones and fertility · Reproductive and sexual health
    Studied dose
    Dose not stated · 2 hoursAs given in this study (horse).

    Measurements

    PGFM pulse peak (induced)
    260 to 380 pg/mL
    oxytocin infusion
    PGFM pulse peak (natural, reported)
    200 to 300 pg/mL
    natural pulse

    Source sentences

    Summary
    The peak of an induced pulse (approximately 260-380 pg/mL) seemed similar to reported natural peaks (approximately 200-300 pg/mL), using the same assay system.
    1 context sentence
    Summary · context
    A procedure for oxytocin (OT) administration on Day 13 postovulation was developed in mares for stimulation of a pulse of PGFM (a PGF2α metabolite) that mimics a natural PGFM pulse during luteolysis.
  5. 05AnimalAnimal study (in vivo)Activity measurement

    In mares, the interval from nadir to nadir of the oxytocin-induced PGFM pulse was 6.6 ± 0.2 hours.

    In plain wordsIn mares, the oxytocin-induced prostaglandin marker pulse lasted about 6.6 hours from low point to low point.

    Peptide
    Oxytocin
    Outcome
    Not applicableInterval from nadir to nadir of induced PGFM pulse
    Study

    horsen: not reported in source

    mares on Day 13 postovulation
    Outcome group
    Sex hormones and fertility · Reproductive and sexual health
    Studied dose
    Dose not stated · 2 hoursAs given in this study (horse).

    Measurements

    Interval nadir to nadir
    6.6 hours
    oxytocin-induced PGFM pulse

    Source sentences

    Summary
    The interval from nadir to nadir was 6.6 ± 0.2 hours.
    1 context sentence
    Summary · context
    A procedure for oxytocin (OT) administration on Day 13 postovulation was developed in mares for stimulation of a pulse of PGFM (a PGF2α metabolite) that mimics a natural PGFM pulse during luteolysis.
  6. 06AnimalAnimal study (in vivo)Efficacy outcome

    In mares, oxytocin infusion at 1.25, 2.5 or 5 IU/100 kg decreased progesterone within 8 hours more than vehicle did (43%-50% versus 11%).

    In plain wordsIn mares, oxytocin infusion lowered progesterone more than vehicle did within 8 hours.

    Peptide
    Oxytocin
    Outcome
    DecreasePercentage decrease in progesterone within 8 hours
    Study

    horsen: not reported in source

    mares on Day 13 postovulation
    Comparator
    Vehicle
    Outcome group
    Sex hormones and fertility · Reproductive and sexual health
    Studied dose
    1.25, 2.5 or 5 IU/100 kg · 2 hoursAs given in this study (horse).

    Measurements

    Progesterone decrease
    43 to 50%
    oxytocin 1.25, 2.5 or 5 IU/100 kg
    Progesterone decrease
    11%
    vehicle

    Source sentences

    Summary
    Percentage decrease in progesterone (P4) within 8 hours was greater (P < 0.05) for doses of 1.25, 2.5, or 5 IU/100 kg (43%-50%) than that for a vehicle group (11%).
    1 context sentence
    Summary · context
    A procedure for oxytocin (OT) administration on Day 13 postovulation was developed in mares for stimulation of a pulse of PGFM (a PGF2α metabolite) that mimics a natural PGFM pulse during luteolysis.

Studies that did not test the peptide alone1

In this study, Oxytocin was a lab tool or a carrier, part of a mix, or the subject of a lab method. These results are not evidence about taking Oxytocin.

  1. 07AnimalNot a test of Oxytocin aloneAnimal study (in vivo)Efficacy outcome

    In mares, flunixin meglumine given 2 hours before an oxytocin infusion of 2.5 IU/100 kg did not prevent the oxytocin-induced PGFM pulses and the decrease in progesterone.

    In plain wordsIn mares, the anti-inflammatory drug flunixin did not stop the oxytocin-induced prostaglandin marker pulse or the progesterone fall.

    Peptide
    Oxytocin
    Outcome
    No significant changeFlunixin pretreatment and the oxytocin-induced PGFM pulse and progesterone decrease
    Study

    horsen: not reported in source

    mares on Day 13 postovulation
    Outcome group
    Sex hormones and fertility · Reproductive and sexual health

    Source sentences

    Summary
    but treatment 2 hours before the beginning of OT infusion (2.5 IU/100 kg) did not prevent the OT-induced PGFM pulses and the decrease in P4.
    1 context sentence
    Summary · context
    A procedure for oxytocin (OT) administration on Day 13 postovulation was developed in mares for stimulation of a pulse of PGFM (a PGF2α metabolite) that mimics a natural PGFM pulse during luteolysis.

    In this study, Oxytocin was a lab tool or a carrier, part of a mix, or the subject of a lab method. This result is not evidence about taking Oxytocin.

AI wrote and checked these results. AI can make mistakes, so check important results against the source.

Version history

PepBank keeps every version of the data on this study. Status changes from Retraction Watch, Europe PMC and Crossref are listed with their source.

  1. Version 2Current

    11 Oct 2026, 01:30 UTC

    Study results updated

  2. Version 1

    9 Oct 2026, 02:50 UTC

    First added · source update from Europe PMC

Subjects

Terms as the source lists them.

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