Skip to content

Study · Randomized controlled trial · n = 15 · 2014

5 results

Oxytocin affects the connectivity of the precuneus and the amygdala: a randomized, double-blinded, placebo-controlled neuroimaging trial.

Kumar J, Völlm B, Palaniyappan L

The international journal of neuropsychopharmacology31 Oct 2014Cited by 29 (Europe PMC)

PMID25522395 (opens in a new tab)PMCIDPMC4376540 (opens in a new tab)DOI10.1093/ijnp/pyu051 (opens in a new tab)PepBankPUB-25522395
Read at sourcePubMedAsk about this study
Jump to 5 results

Summary

The text of this summary is not shown here, because the article license does not allow reuse. Read it at the source (opens in a new tab)

Text rights: CC BY-NC. Results still quote short attributed sentences.

Results from this study5

5 results from studies that gave the peptide. 5 results from people.

  1. 01HumanRandomized controlled trialMechanism

    In healthy men, intranasal oxytocin 24 IU reduced the degree centrality of the right precuneus versus placebo.

    In plain wordsIn healthy men, oxytocin lowered one measure of activity connection in a brain area called the right precuneus, compared with placebo.

    Peptide
    Oxytocin
    Outcome
    DecreaseDegree centrality of the right precuneus
    Study

    n = 15

    Comparator
    Placebo
    Outcome group
    Brain and neuronal activity · Nervous system and cognition
    Studied dose
    24 IU · intranasalAs given in this study (human).

    Source sentences

    Summary
    We found that oxytocin significantly reduced the degree centrality of the right precuneus (P<.05).
    1 context sentence
    Summary · context
    Using a randomized, double-blinded, placebo-controlled, crossover design, 15 healthy male volunteers received 24 IU intranasal oxytocin or placebo prior to resting-state functional MRI acquisition at 3T.
  2. 02HumanRandomized controlled trialMechanism

    In healthy men, intranasal oxytocin reduced connectivity between the bilateral amygdalae versus placebo.

    In plain wordsIn healthy men, oxytocin lowered the connection between the left and right amygdala in the brain, compared with placebo.

    Peptide
    Oxytocin
    Outcome
    DecreaseConnectivity between the bilateral amygdalae
    Study

    n = 15

    Comparator
    Placebo
    Outcome group
    Brain and neuronal activity · Nervous system and cognition
    Studied dose
    24 IU · intranasalAs given in this study (human).

    Source sentences

    Summary
    Oxytocin also reduced connectivity between the bilateral amygdalae and between the right precuneus and the right and left amygdala (P<.05).
    1 context sentence
    Summary · context
    Using a randomized, double-blinded, placebo-controlled, crossover design, 15 healthy male volunteers received 24 IU intranasal oxytocin or placebo prior to resting-state functional MRI acquisition at 3T.
  3. 03HumanRandomized controlled trialMechanism

    In healthy men, intranasal oxytocin reduced connectivity between the right precuneus and the right and left amygdala versus placebo.

    In plain wordsIn healthy men, oxytocin lowered the connection between the right precuneus and both amygdalae in the brain, compared with placebo.

    Peptide
    Oxytocin
    Outcome
    DecreaseConnectivity between the right precuneus and the amygdalae
    Study

    n = 15

    Comparator
    Placebo
    Outcome group
    Brain and neuronal activity · Nervous system and cognition
    Studied dose
    24 IU · intranasalAs given in this study (human).

    Source sentences

    Summary
    between the right precuneus and the right and left amygdala (P<.05).
    1 context sentence
    Summary · context
    Using a randomized, double-blinded, placebo-controlled, crossover design, 15 healthy male volunteers received 24 IU intranasal oxytocin or placebo prior to resting-state functional MRI acquisition at 3T.
  4. 04HumanRandomized controlled trialMechanism

    In healthy men, intranasal oxytocin caused no significant change in regional homogeneity at the whole brain level versus placebo.

    In plain wordsIn healthy men, oxytocin did not significantly change one brain activity measure across the whole brain, compared with placebo.

    Peptide
    Oxytocin
    Outcome
    No significant changeRegional homogeneity, whole brain
    Study

    n = 15

    Comparator
    Placebo
    Outcome group
    Brain and neuronal activity · Nervous system and cognition
    Studied dose
    24 IU · intranasalAs given in this study (human).

    Source sentences

    Summary
    there were no significant changes in regional homogeneity at the whole brain level
    1 context sentence
    Summary · context
    Using a randomized, double-blinded, placebo-controlled, crossover design, 15 healthy male volunteers received 24 IU intranasal oxytocin or placebo prior to resting-state functional MRI acquisition at 3T.
  5. 05HumanRandomized controlled trialMechanism

    In healthy men, a post hoc analysis showed that intranasal oxytocin reduced regional homogeneity in the right precuneus versus placebo.

    In plain wordsIn healthy men, a follow-up analysis found oxytocin lowered one brain activity measure in the right precuneus, compared with placebo.

    Peptide
    Oxytocin
    Outcome
    DecreaseRegional homogeneity, right precuneus (post hoc)
    Study

    n = 15

    Comparator
    Placebo
    Outcome group
    Brain and neuronal activity · Nervous system and cognition
    Studied dose
    24 IU · intranasalAs given in this study (human).

    Source sentences

    Summary
    posthoc results showed a reduction involving the right precuneus (P<.05).
    1 context sentence
    Summary · context
    Using a randomized, double-blinded, placebo-controlled, crossover design, 15 healthy male volunteers received 24 IU intranasal oxytocin or placebo prior to resting-state functional MRI acquisition at 3T.

AI wrote and checked these results. AI can make mistakes, so check important results against the source.

Version history

PepBank keeps every version of the data on this study. Status changes from Retraction Watch, Europe PMC and Crossref are listed with their source.

  1. Version 2Current

    11 Oct 2026, 01:30 UTC

    Study results updated

  2. Version 1

    9 Oct 2026, 02:49 UTC

    First added · source update from Europe PMC

Subjects

Terms as the source lists them.

PepBank is a research reference. Talk to a doctor before you use any peptide.