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Study · Systematic review · 2015

4 results

Neurophysiological effects of acute oxytocin administration: systematic review and meta-analysis of placebo-controlled imaging studies.

Wigton R, Radua J, Allen P, Averbeck B, Meyer-Lindenberg A, McGuire P, Shergill SS, Fusar-Poli P

Journal of psychiatry & neuroscience : JPN1 Jan 2015Cited by 148 (Europe PMC)

PMID25520163 (opens in a new tab)PMCIDPMC4275335 (opens in a new tab)DOI10.1503/jpn.130289 (opens in a new tab)PepBankPUB-25520163
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Summary

The text of this summary is not shown here, because the article license does not allow reuse. Read it at the source (opens in a new tab)

Text rights: Publisher copyright. Results still quote short attributed sentences.

Results from this study4

4 results from studies that gave the peptide. 4 results from people.

  1. 01HumanSystematic reviewMechanism

    In placebo-controlled imaging studies, oxytocin altered activation of brain regions, including the temporal lobes and insula, during processing of social stimuli.

    In plain wordsIn brain imaging studies, oxytocin changed activity in several brain regions, including the temporal lobes and insula, during social tasks.

    Peptide
    Oxytocin
    Outcome
    MixedBrain activation during social stimuli
    Study

    n: not reported in source

    Comparator
    Placebo
    Outcome group
    Brain and neuronal activity · Nervous system and cognition
    Studied dose
    Dose not stated

    Source sentences

    Summary
    The results demonstrate consistent alterations in activation of brain regions, including the temporal lobes and insula, during the processing of social stimuli, with some variation dependent on sex and task.
    2 context sentences
    Summary · context
    We conducted a systematic literature review of placebo-controlled imaging studies using OXT as a pharmacological manipulator of brain activity.
    Summary · context
    We identified a total of 21 studies for inclusion in our review, and after applying additional selection criteria, 11 of them were included in our fMRI voxel-based meta-analysis.
  2. 02HumanSystematic reviewMechanism

    The alterations in brain activation after oxytocin showed some variation dependent on sex and task.

    In plain wordsThe brain activity changes after oxytocin varied somewhat by sex and by task.

    Peptide
    Oxytocin
    Outcome
    MixedModulation of oxytocin effects on brain activation by sex and task
    Study

    n: not reported in source

    Comparator
    Placebo
    Outcome group
    Brain and neuronal activity · Nervous system and cognition
    Studied dose
    Dose not stated

    Source sentences

    Summary
    with some variation dependent on sex and task.
    2 context sentences
    Summary · context
    We conducted a systematic literature review of placebo-controlled imaging studies using OXT as a pharmacological manipulator of brain activity.
    Summary · context
    We identified a total of 21 studies for inclusion in our review, and after applying additional selection criteria, 11 of them were included in our fMRI voxel-based meta-analysis.
  3. 03HumanSystematic reviewMechanism

    The voxel-based meta-analysis showed significant left insular hyperactivation after oxytocin administration.

    In plain wordsIn pooled brain scans, a part of the brain called the left insula was more active after oxytocin.

    Peptide
    Oxytocin
    Outcome
    IncreaseLeft insula activation in the fMRI meta-analysis
    Study

    n: not reported in source

    Comparator
    Placebo
    Outcome group
    Brain and neuronal activity · Nervous system and cognition
    Studied dose
    Dose not stated

    Source sentences

    Summary
    The meta-analysis revealed significant left insular hyperactivation after OXT administration, suggesting a potential modulation of neural circuits underlying emotional processing.
    2 context sentences
    Summary · context
    We conducted a systematic literature review of placebo-controlled imaging studies using OXT as a pharmacological manipulator of brain activity.
    Summary · context
    We identified a total of 21 studies for inclusion in our review, and after applying additional selection criteria, 11 of them were included in our fMRI voxel-based meta-analysis.
  4. 04HumanSystematic reviewMechanism

    The magnitude of oxytocin-related neural activation was largest in the temporal lobes.

    In plain wordsBrain activity changes after oxytocin were largest in the temporal lobes.

    Peptide
    Oxytocin
    Outcome
    IncreaseMagnitude of neural activation in the temporal lobes
    Study

    n: not reported in source

    Comparator
    Placebo
    Outcome group
    Brain and neuronal activity · Nervous system and cognition
    Studied dose
    Dose not stated

    Source sentences

    Summary
    The magnitude of this neural activation is largest in the temporal lobes
    2 context sentences
    Summary · context
    We conducted a systematic literature review of placebo-controlled imaging studies using OXT as a pharmacological manipulator of brain activity.
    Summary · context
    We identified a total of 21 studies for inclusion in our review, and after applying additional selection criteria, 11 of them were included in our fMRI voxel-based meta-analysis.

AI wrote and checked these results. AI can make mistakes, so check important results against the source.

Version history

PepBank keeps every version of the data on this study. Status changes from Retraction Watch, Europe PMC and Crossref are listed with their source.

  1. Version 2Current

    9 Oct 2026, 18:17 UTC

    Study results updated

  2. Version 1

    9 Oct 2026, 02:50 UTC

    First added · source update from Europe PMC

Subjects

Terms as the source lists them.

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