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Study · Measured the body's own peptide · 2013

3 results

[Igf-1 and its isoform expression in hepatic cell tumors and the surrounding tissue in mice liver carcinogenesis induced by diethylnitrozamine].

Zinevich LS, Goncharova NO, Uruvaeva IV, Delone GV, Mikaelian AS

Izvestiia Akademii nauk. Seriia biologicheskaia1 Nov 2013Cited by 4 (Europe PMC)

PMID25518553 (opens in a new tab)DOI10.1134/s1062359013060150 (opens in a new tab)PepBankPUB-25518553
Publisher pagePubMedAsk about this study
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Summary

The text of this summary is not shown here, because the article license does not allow reuse. Read it at the source (opens in a new tab)

Text rights: Publisher copyright. Results still quote short attributed sentences.

Results from this study3

No result from this study comes from a test of the peptide.

Natural levels measured3

These results measure the body's own peptide. Nobody was given the peptide. They are not evidence about taking it. They are left out of key results, evidence counts and charts.

  1. 01AnimalEndogenous levelAnimal study (in vivo)Other

    In mice with diethylnitrosamine-induced liver cancer, Mgf mRNA was lower in hepatocellular carcinoma than in control samples.

    In plain wordsIn mice with liver cancer, the body's own MGF gene activity was lower in the tumor than in control liver.

    Peptide
    MGF / PEG-MGF
    Outcome
    DecreaseMgf mRNA in hepatocellular carcinoma
    Study

    mousen: not reported in source

    Diethylnitrosamine-induced liver carcinogenesis
    Comparator
    Control group
    Outcome group
    Tumor growth · Cancer

    Source sentences

    Summary
    By the means of semiquantitative evaluation of the products of two Igf-1 splice isoforms--locally active (Mgf) and circulating (Igf- 1v4)--it has been shown that the amount of mRNA of both isoforms in hepatocellular carcinoma was lower, and in tissue surrounding the tumor higher, than in the samples…
    1 context sentence
    Summary · context
    The expression of the Igf-1 gene in mice liver at different stages of development of hepatocellular carcinoma induced by diethylnitrozamine--from the initial diffuse tissue dysplasia and nodular hyperplasia to the development of multiple adenomas and carcinoma--has been analyzed.

    This result measures the body's own MGF / PEG-MGF. Nobody was given the peptide. It is not evidence about taking it.

  2. 02AnimalEndogenous levelAnimal study (in vivo)Other

    In mice with diethylnitrosamine-induced liver cancer, Mgf mRNA was higher in tissue surrounding the tumor than in control samples.

    In plain wordsIn mice with liver cancer, the body's own MGF gene activity was higher in the tissue around the tumor than in control liver.

    Peptide
    MGF / PEG-MGF
    Outcome
    IncreaseMgf mRNA in tissue surrounding the tumor
    Study

    mousen: not reported in source

    Diethylnitrosamine-induced liver carcinogenesis
    Comparator
    Control group
    Outcome group
    Tumor growth · Cancer

    Source sentences

    Summary
    By the means of semiquantitative evaluation of the products of two Igf-1 splice isoforms--locally active (Mgf) and circulating (Igf- 1v4)--it has been shown that the amount of mRNA of both isoforms in hepatocellular carcinoma was lower, and in tissue surrounding the tumor higher, than in the samples…
    1 context sentence
    Summary · context
    The expression of the Igf-1 gene in mice liver at different stages of development of hepatocellular carcinoma induced by diethylnitrozamine--from the initial diffuse tissue dysplasia and nodular hyperplasia to the development of multiple adenomas and carcinoma--has been analyzed.

    This result measures the body's own MGF / PEG-MGF. Nobody was given the peptide. It is not evidence about taking it.

  3. 03AnimalEndogenous levelAnimal study (in vivo)Other

    In mice with diethylnitrosamine-induced liver cancer, the proportion of Mgf and Igf-1v4 transcripts was stable.

    In plain wordsIn mice with liver cancer, the share of natural MGF among the IGF-1 gene products stayed the same.

    Peptide
    MGF / PEG-MGF
    Outcome
    No significant changeProportion of Mgf and Igf-1v4 transcripts
    Study

    mousen: not reported in source

    Diethylnitrosamine-induced liver carcinogenesis
    Outcome group
    Tumor growth · Cancer

    Source sentences

    Summary
    At the same time, the proportion of transcripts of isoforms was stable.

    This result measures the body's own MGF / PEG-MGF. Nobody was given the peptide. It is not evidence about taking it.

AI wrote and checked these results. AI can make mistakes, so check important results against the source.

Version history

PepBank keeps every version of the data on this study. Status changes from Retraction Watch, Europe PMC and Crossref are listed with their source.

  1. Version 2Current

    13 Oct 2026, 21:44 UTC

    Study results updated

  2. Version 1

    13 Oct 2026, 16:31 UTC

    First added · source update from Europe PMC

Subjects

Terms as the source lists them.

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