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Study · Not a test of the peptide alone · 2015

4 results

Topical delivery of acetyl hexapeptide-8 from different emulsions: influence of emulsion composition and internal structure.

Hoppel M, Reznicek G, Kählig H, Kotisch H, Resch GP, Valenta C

European journal of pharmaceutical sciences : official journal of the European Federation for Pharmaceutical Sciences9 Dec 2014Cited by 30 (Europe PMC)

PMID25497319 (opens in a new tab)DOI10.1016/j.ejps.2014.12.006 (opens in a new tab)PepBankPUB-25497319
Publisher pagePubMedAsk about this study
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Summary

The text of this summary is not shown here, because the article license does not allow reuse. Read it at the source (opens in a new tab)

Text rights: Publisher copyright. Results still quote short attributed sentences.

Results from this study4

No result from this study comes from a test of the peptide.

Studies that did not test the peptide alone4

In this study, Argireline (acetyl hexapeptide-8) was a lab tool or a carrier, part of a mix, or the subject of a lab method. These results are not evidence about taking Argireline (acetyl hexapeptide-8).

  1. 01LabNot a test of Argireline (acetyl hexapeptide-8) aloneEx vivo tissuePharmacokinetics

    In porcine skin, a multiple W/O/W emulsion increased acetyl hexapeptide‑8 penetration versus simple O/W emulsion.

    In plain wordsIn lab tests on pig skin, W/O/W emulsion increased acetyl hexapeptide‑8 penetration versus simple O/W emulsion.

    Peptide
    Argireline (acetyl hexapeptide-8)
    Outcome
    IncreaseSkin penetration with multiple emulsion versus O/W
    Study

    pign: not reported in source

    Porcine ear skin
    Comparator
    Simple O/W emulsion
    Outcome group
    Pharmacokinetics · Pharmacology

    Source sentences

    Summary
    By applying LC-MS/MS for quantification of AH-8, we demonstrated that a multiple water-in-oil-in-water (W/O/W) emulsion can significantly increase penetration of AH-8 into porcine skin compared to simple O/W and W/O emulsions.
    1 context sentence
    Summary · context
    Besides skin permeation experiments with Franz type diffusion cells, the spatial distribution of AH-8 in the stratum corneum after a real in-use application was investigated by in vitro tape stripping on porcine ear skin.

    In this study, Argireline (acetyl hexapeptide-8) was a lab tool or a carrier, part of a mix, or the subject of a lab method. This result is not evidence about taking Argireline (acetyl hexapeptide-8).

  2. 02LabNot a test of Argireline (acetyl hexapeptide-8) aloneEx vivo tissuePharmacokinetics

    In porcine skin, a multiple W/O/W emulsion increased acetyl hexapeptide‑8 penetration versus simple W/O emulsion.

    In plain wordsIn lab tests on pig skin, W/O/W emulsion increased acetyl hexapeptide‑8 penetration versus simple W/O emulsion.

    Peptide
    Argireline (acetyl hexapeptide-8)
    Outcome
    IncreaseSkin penetration with multiple emulsion versus W/O
    Study

    pign: not reported in source

    Porcine ear skin
    Comparator
    Simple W/O emulsion
    Outcome group
    Pharmacokinetics · Pharmacology

    Source sentences

    Summary
    By applying LC-MS/MS for quantification of AH-8, we demonstrated that a multiple water-in-oil-in-water (W/O/W) emulsion can significantly increase penetration of AH-8 into porcine skin compared to simple O/W and W/O emulsions.
    1 context sentence
    Summary · context
    Besides skin permeation experiments with Franz type diffusion cells, the spatial distribution of AH-8 in the stratum corneum after a real in-use application was investigated by in vitro tape stripping on porcine ear skin.

    In this study, Argireline (acetyl hexapeptide-8) was a lab tool or a carrier, part of a mix, or the subject of a lab method. This result is not evidence about taking Argireline (acetyl hexapeptide-8).

  3. 03LabNot a test of Argireline (acetyl hexapeptide-8) aloneEx vivo tissuePharmacokinetics

    In porcine skin, water-rich O/W emulsion delivered acetyl hexapeptide‑8 better than oil-rich W/O emulsion.

    In plain wordsIn lab tests on pig skin, water-rich O/W emulsion delivered acetyl hexapeptide‑8 better than oil-rich W/O emulsion.

    Peptide
    Argireline (acetyl hexapeptide-8)
    Outcome
    IncreaseDermal delivery with water-rich O/W versus W/O
    Study

    pign: not reported in source

    Porcine ear skin
    Comparator
    Oil-rich W/O emulsion
    Outcome group
    Pharmacokinetics · Pharmacology

    Source sentences

    Summary
    In general, a clear superiority of water-rich W/O/W and O/W emulsions over an oil-rich W/O emulsion in terms of dermal delivery of AH-8 was found.
    1 context sentence
    Summary · context
    Besides skin permeation experiments with Franz type diffusion cells, the spatial distribution of AH-8 in the stratum corneum after a real in-use application was investigated by in vitro tape stripping on porcine ear skin.

    In this study, Argireline (acetyl hexapeptide-8) was a lab tool or a carrier, part of a mix, or the subject of a lab method. This result is not evidence about taking Argireline (acetyl hexapeptide-8).

  4. 04LabNot a test of Argireline (acetyl hexapeptide-8) aloneEx vivo tissueMechanism

    In porcine skin, increased absorption of water-rich emulsions could explain enhanced acetyl hexapeptide‑8 delivery.

    In plain wordsIn lab tests on pig skin, greater absorption of water-rich emulsions could explain their enhanced acetyl hexapeptide‑8 delivery.

    Peptide
    Argireline (acetyl hexapeptide-8)
    Outcome
    IncreaseVehicle absorption associated with enhanced peptide delivery
    Study

    pign: not reported in source

    Porcine ear skin
    Outcome group
    Pharmacokinetics · Pharmacology

    Source sentences

    Summary
    This enhanced delivery of AH-8 could be explained by an increased absorption of the water-rich emulsions into the skin, confirmed by combined ATR-FTIR and tape stripping experiments.
    1 context sentence
    Summary · context
    Besides skin permeation experiments with Franz type diffusion cells, the spatial distribution of AH-8 in the stratum corneum after a real in-use application was investigated by in vitro tape stripping on porcine ear skin.

    In this study, Argireline (acetyl hexapeptide-8) was a lab tool or a carrier, part of a mix, or the subject of a lab method. This result is not evidence about taking Argireline (acetyl hexapeptide-8).

AI wrote and checked these results. AI can make mistakes, so check important results against the source.

Version history

PepBank keeps every version of the data on this study. Status changes from Retraction Watch, Europe PMC and Crossref are listed with their source.

  1. Version 2Current

    22 Oct 2026, 02:25 UTC

    Study results updated

  2. Version 1

    21 Oct 2026, 18:59 UTC

    First added · source update from Europe PMC

Subjects

Terms as the source lists them.

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