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Study · Animal study (in vivo) · mouse · 2015

8 results

Adenosine monophosphate-activated protein kinase activation protects against sepsis-induced organ injury and inflammation.

Escobar DA, Botero-Quintero AM, Kautza BC, Luciano J, Loughran P, Darwiche S, Rosengart MR, Zuckerbraun BS, Gomez H

The Journal of surgical research8 Oct 2014Cited by 94 (Europe PMC)

PMID25456115 (opens in a new tab)PMCIDPMC4346495 (opens in a new tab)DOI10.1016/j.jss.2014.10.009 (opens in a new tab)PepBankPUB-25456115
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Summary

The text of this summary is not shown here, because the article license does not allow reuse. Read it at the source (opens in a new tab)

Text rights: Publisher copyright. Results still quote short attributed sentences.

Results from this study8

8 results from studies that gave the peptide. No result from this study comes from people.

  1. 01AnimalAnimal study (in vivo)Efficacy outcome

    In mice with CLP-induced sepsis, AICAR decreased liver injury.

    In plain wordsIn mice with sepsis, AICAR reduced liver injury compared with vehicle.

    Peptide
    AICAR (acadesine)
    Outcome
    DecreaseLiver injury
    Study

    mousen: not reported in source

    Cecal ligation and puncture sepsis
    Comparator
    Vehicle
    Outcome group
    Liver fat and liver function · Liver
    Studied dose
    Dose not stated

    Source sentences

    Summary
    AICAR decreased liver and kidney injury induced by CLP and minimized cytokine elevation in vivo and in vitro.
    1 context sentence
    Summary · context
    Wild-type mice underwent cecal ligation and puncture (CLP) or sham surgery. Mice were randomized to vehicle, AICAR, or compound C.
  2. 02AnimalAnimal study (in vivo)Efficacy outcome

    In mice with CLP-induced sepsis, AICAR decreased kidney injury.

    In plain wordsIn mice with sepsis, AICAR reduced kidney injury compared with vehicle.

    Peptide
    AICAR (acadesine)
    Outcome
    DecreaseKidney injury
    Study

    mousen: not reported in source

    Cecal ligation and puncture sepsis
    Comparator
    Vehicle
    Outcome group
    Kidney function · Kidney and urinary
    Studied dose
    Dose not stated

    Source sentences

    Summary
    AICAR decreased liver and kidney injury induced by CLP and minimized cytokine elevation in vivo and in vitro.
    1 context sentence
    Summary · context
    Wild-type mice underwent cecal ligation and puncture (CLP) or sham surgery. Mice were randomized to vehicle, AICAR, or compound C.
  3. 03AnimalAnimal study (in vivo)Efficacy outcome

    In mice with CLP-induced sepsis, AICAR minimized cytokine elevation.

    In plain wordsIn mice with sepsis, AICAR reduced cytokine elevation compared with vehicle.

    Peptide
    AICAR (acadesine)
    Outcome
    DecreaseCytokine elevation in vivo
    Study

    mousen: not reported in source

    Cecal ligation and puncture sepsis
    Comparator
    Vehicle
    Outcome group
    Inflammation markers · Immune and inflammation
    Studied dose
    Dose not stated

    Source sentences

    Summary
    AICAR decreased liver and kidney injury induced by CLP and minimized cytokine elevation in vivo and in vitro.
    1 context sentence
    Summary · context
    Wild-type mice underwent cecal ligation and puncture (CLP) or sham surgery. Mice were randomized to vehicle, AICAR, or compound C.
  4. 04AnimalAnimal study (in vivo)Efficacy outcome

    In mice, AICAR limited CLP-induced endothelial injury assessed by electron microscopy and Evans blue dye extravasation.

    In plain wordsIn mice with sepsis, AICAR reduced blood vessel lining injury compared with vehicle.

    Peptide
    AICAR (acadesine)
    Outcome
    DecreaseEndothelial injury
    Study

    mousen: not reported in source

    Cecal ligation and puncture sepsis
    Comparator
    Vehicle
    Outcome group
    Vascular function · Cardiovascular
    Studied dose
    Dose not stated

    Source sentences

    Summary
    Additionally, CLP led to endothelial injury as determined by electron microscopy and Evans blue dye extravasation, and AICAR limited this injury.
    1 context sentence
    Summary · context
    Wild-type mice underwent cecal ligation and puncture (CLP) or sham surgery. Mice were randomized to vehicle, AICAR, or compound C.
  5. 05AnimalAnimal study (in vivo)Mechanism

    In mice, AICAR limited CLP-induced intracellular adhesion molecule upregulation.

    In plain wordsIn mice, AICAR reduced adhesion molecule increases compared with vehicle after CLP.

    Peptide
    AICAR (acadesine)
    Outcome
    DecreaseIntracellular adhesion molecule upregulation in vivo
    Study

    mousen: not reported in source

    Cecal ligation and puncture sepsis
    Comparator
    Vehicle
    Outcome group
    Inflammation markers · Immune and inflammation
    Studied dose
    Dose not stated

    Source sentences

    Summary
    Furthermore, AICAR limited CLP and lipopolysaccharide (LPS)-induced upregulation of intracellular adhesion molecule in vivo and in vitro and decreased LPS-induced neutrophil adhesion in vitro.
    1 context sentence
    Summary · context
    Wild-type mice underwent cecal ligation and puncture (CLP) or sham surgery. Mice were randomized to vehicle, AICAR, or compound C.
  6. 06LabIn vitro (cells)Efficacy outcome

    In mouse kidney endothelial cells, AICAR minimized cytokine elevation.

    In plain wordsIn cells from mice, AICAR reduced cytokine elevation.

    Peptide
    AICAR (acadesine)
    Outcome
    DecreaseCytokine elevation in vitro
    Study

    mousen: not reported in source

    Mouse kidney endothelial cells
    Outcome group
    Inflammation markers · Immune and inflammation
    Studied dose
    Dose not stated

    Source sentences

    Summary
    AICAR decreased liver and kidney injury induced by CLP and minimized cytokine elevation in vivo and in vitro.
    1 context sentence
    Summary · context
    Mouse kidney endothelial cells were used for in vitro experiments.
  7. 07LabIn vitro (cells)Mechanism

    In mouse kidney endothelial cells, AICAR limited LPS-induced intracellular adhesion molecule upregulation.

    In plain wordsIn cells from mice, AICAR reduced LPS-induced adhesion molecule increases.

    Peptide
    AICAR (acadesine)
    Outcome
    DecreaseIntracellular adhesion molecule upregulation in vitro
    Study

    mousen: not reported in source

    LPS-treated mouse kidney endothelial cells
    Outcome group
    Inflammation markers · Immune and inflammation
    Studied dose
    Dose not stated

    Source sentences

    Summary
    Furthermore, AICAR limited CLP and lipopolysaccharide (LPS)-induced upregulation of intracellular adhesion molecule in vivo and in vitro and decreased LPS-induced neutrophil adhesion in vitro.
    1 context sentence
    Summary · context
    Mouse kidney endothelial cells were used for in vitro experiments.
  8. 08LabIn vitro (cells)Mechanism

    In mouse kidney endothelial cell experiments, AICAR decreased LPS-induced neutrophil adhesion.

    In plain wordsIn cells from mice, AICAR reduced LPS-induced neutrophil attachment.

    Peptide
    AICAR (acadesine)
    Outcome
    DecreaseNeutrophil adhesion
    Study

    mousen: not reported in source

    LPS-treated mouse kidney endothelial cells
    Outcome group
    Immune response · Immune and inflammation
    Studied dose
    Dose not stated

    Source sentences

    Summary
    Furthermore, AICAR limited CLP and lipopolysaccharide (LPS)-induced upregulation of intracellular adhesion molecule in vivo and in vitro and decreased LPS-induced neutrophil adhesion in vitro.
    1 context sentence
    Summary · context
    Mouse kidney endothelial cells were used for in vitro experiments.

AI wrote and checked these results. AI can make mistakes, so check important results against the source.

Version history

PepBank keeps every version of the data on this study. Status changes from Retraction Watch, Europe PMC and Crossref are listed with their source.

  1. Version 2Current

    21 Oct 2026, 15:58 UTC

    Study results updated

  2. Version 1

    21 Oct 2026, 12:50 UTC

    First added · source update from Europe PMC

Subjects

Terms as the source lists them.

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