Study · In vitro (cells) · rat · 2015

2 results

Emoghrelin, a unique emodin derivative in Heshouwu, stimulates growth hormone secretion via activation of the ghrelin receptor.

Lo YH, Chen YJ, Chung TY, Lin NH, Chen WY, Chen CY, Lee MR, Chou CC, Tzen JT

Journal of ethnopharmacology8 Nov 2014Cited by 17 (Europe PMC)

PMID25446595DOI10.1016/j.jep.2014.10.063PepBankPUB-25446595

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Summary

The text of this summary is not shown here, because the article license does not allow reuse. Read it at the source (opens in a new tab)

Text rights: Publisher copyright. Results still quote short attributed sentences.

Results from this study2

1 result from studies that gave the peptide. No result from this study comes from people.

01LabIn vitro (cells)Activity measurement
In rat anterior pituitary cells, GHRP‑6 stimulated growth hormone secretion, as did emoghrelin.
In plain wordsIn cells from rats, GHRP‑6 stimulated growth hormone secretion, similar to emoghrelin.
Peptide
GHRP-6
Outcome
IncreaseGrowth hormone secretion
Study
ratn: not reported in source
Primary anterior pituitary cells
Outcome group
Growth hormone and IGF-1 · Endocrine and hormones
Studied dose
Dose not stated
Source sentences
Summary
Similar to growth hormone-releasing hormone-6 (GHRP-6), a synthetic analog of ghrelin, emoghrelin was demonstrated to stimulate growth hormone secretion of rat primary anterior pituitary cells in a dose dependent manner
Report a problemFND-2544659501

Studies that did not test the peptide alone1

In this study, GHRP-6 was a lab tool or a carrier, part of a mix, or the subject of a lab method. These results are not evidence about taking GHRP-6.

02Computer modelNot a test of GHRP-6 aloneIn silicoMechanism
In molecular modeling, GHRP‑6 could fit and interact adequately with the ghrelin receptor binding pocket.
In plain wordsComputer models showed that GHRP‑6 could fit and interact with the ghrelin receptor pocket.
Peptide
GHRP-6
Outcome
Not applicableGhrelin receptor pocket interaction
Study
n: not reported in source
Outcome group
Receptor activity and mechanism · Pharmacology
Source sentences
Summary
Molecular modeling and docking showed that emoghrelin as well as GHRP-6 could fit in and adequately interact with the binding pocket of the ghrelin receptor.
In this study, GHRP-6 was a lab tool or a carrier, part of a mix, or the subject of a lab method. This result is not evidence about taking GHRP-6.
Report a problemFND-2544659502

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Version history

PepBank keeps every version of the data on this study. Status changes from Retraction Watch, Europe PMC and Crossref are listed with their source.

Version 2Current
21 Oct 2026, 15:58 UTC
Study results updated
Version 1
9 Oct 2026, 03:13 UTC
First added · source update from Europe PMC

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