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Study · Randomized controlled trial · n = 29 · 2015

2 results

Oxytocin and vasopressin modulate risk-taking.

Patel N, Grillon C, Pavletic N, Rosen D, Pine DS, Ernst M

Physiology & behavior12 Nov 2014Cited by 26 (Europe PMC)

PMID25446228 (opens in a new tab)PMCIDPMC4274653 (opens in a new tab)DOI10.1016/j.physbeh.2014.11.018 (opens in a new tab)PepBankPUB-25446228
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Summary

The text of this summary is not shown here, because the article license does not allow reuse. Read it at the source (opens in a new tab)

Text rights: Publisher copyright. Results still quote short attributed sentences.

Results from this study2

2 results from studies that gave the peptide. 2 results from people.

  1. 01HumanRandomized controlled trialEfficacy outcome

    In twenty-nine healthy adults, oxytocin reduced betting rate in the Stunt risk-taking task compared with placebo.

    In plain wordsIn healthy adults, oxytocin spray lowered risky betting compared with placebo.

    Peptide
    Oxytocin
    Outcome
    DecreaseBetting rate in risk-taking task
    Study

    n = 29

    Comparator
    Placebo
    Outcome group
    Social behavior and cognition · Mental health and mood
    Studied dose
    Dose not stated · intranasalAs given in this study (human).

    Source sentences

    Summary
    OT and AVP relative to PLC reduced betting-rate (risk-averse effect).
    2 context sentences
    Summary · context
    Twenty-nine healthy adults (14 males) completed a risk-taking task, the Stunt task, both in a social-stress (evaluation by unfamiliar peers) and non-social context, in three separate drug treatment sessions.
    Summary · context
    During each session, one of three drugs, OT, AVP, or placebo (PLC), was administered intra-nasally.
  2. 02HumanRandomized controlled trialEfficacy outcome

    In twenty-nine healthy adults, oxytocin reduced risk-taking in the negative risk-valence (low win-probability) condition, and only in the social-stress context and in men.

    In plain wordsIn healthy adults, oxytocin lowered risk-taking only in unlikely-to-win bets, under social stress, and in men.

    Peptide
    Oxytocin
    Outcome
    DecreaseRisk-taking in negative risk-valence, social-stress context, men
    Study

    n = 29

    Comparator
    Placebo
    Outcome group
    Anxiety and mood · Mental health and mood
    Studied dose
    Dose not stated · intranasalAs given in this study (human).

    Source sentences

    Summary
    In contrast, OT reduced risk-taking in the negative risk-valence (low win-probability), and only in the social-stress context and men.
    2 context sentences
    Summary · context
    Twenty-nine healthy adults (14 males) completed a risk-taking task, the Stunt task, both in a social-stress (evaluation by unfamiliar peers) and non-social context, in three separate drug treatment sessions.
    Summary · context
    During each session, one of three drugs, OT, AVP, or placebo (PLC), was administered intra-nasally.

AI wrote and checked these results. AI can make mistakes, so check important results against the source.

Version history

PepBank keeps every version of the data on this study. Status changes from Retraction Watch, Europe PMC and Crossref are listed with their source.

  1. Version 2Current

    11 Oct 2026, 01:30 UTC

    Study results updated

  2. Version 1

    9 Oct 2026, 02:49 UTC

    First added · source update from Europe PMC

Subjects

Terms as the source lists them.

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