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Study · Animal study (in vivo) · mouse · 2014

6 results

Modulation of inflammation response to murine cutaneous Leishmaniosis by homeopathic medicines: thymulin 5cH.

Rodrigues de Santana F, Coelho Cde P, Cardoso TN, Laurenti MD, Perez Hurtado EC, Bonamin LV

Homeopathy : the journal of the Faculty of Homeopathy3 Oct 2014Cited by 7 (Europe PMC)

PMID25439044 (opens in a new tab)DOI10.1016/j.homp.2014.08.002 (opens in a new tab)PepBankPUB-25439044
Publisher pagePubMedAsk about this study
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Summary

The text of this summary is not shown here, because the article license does not allow reuse. Read it at the source (opens in a new tab)

Text rights: Publisher copyright. Results still quote short attributed sentences.

Results from this study6

6 results from studies that gave the peptide. No result from this study comes from people.

  1. 01AnimalAnimal study (in vivo)Efficacy outcome

    In infected mice, homeopathic thymulin 5cH transiently increased peritoneal Treg cells.

    In plain wordsIn infected mice, homeopathic thymulin 5cH temporarily increased peritoneal Treg cells compared with vehicle.

    Peptide
    Thymulin (serum thymic factor)
    Outcome
    IncreaseTransient peritoneal Treg increase
    Study

    mousen: not reported in source

    Leishmania amazonensis-infected male Balb/c mice
    Comparator
    Vehicle
    Outcome group
    Immune response · Immune and inflammation
    Studied dose
    5cH · oral · 60 daysAs given in this study (mouse).

    Source sentences

    Summary
    After a transitory increase of peritoneal T reg cells
    1 context sentence
    Summary · context
    Male Balb/c mice were orally treated with thymulin 5cH or vehicle during 60 days, after the subcutaneous inoculation of 2 × 10(6) units of Leishmania (L.) amazonensis into the footpad.
  2. 02AnimalAnimal study (in vivo)Efficacy outcome

    In infected mice, homeopathic thymulin 5cH increased peritoneal B1 cell percentage relative to other cell types.

    In plain wordsIn infected mice, homeopathic thymulin 5cH increased peritoneal B1 cell percentages relative to other cell types.

    Peptide
    Thymulin (serum thymic factor)
    Outcome
    IncreasePeritoneal B1 cell percentage
    Study

    mousen: not reported in source

    Leishmania amazonensis-infected male Balb/c mice
    Comparator
    Vehicle
    Outcome group
    Immune response · Immune and inflammation
    Studied dose
    5cH · oral · 60 daysAs given in this study (mouse).

    Source sentences

    Summary
    treated mice presented, chronically, increase in the peritoneal and spleen B1 cells percentage (p = 0.0001) in relation to other cell types
    1 context sentence
    Summary · context
    Male Balb/c mice were orally treated with thymulin 5cH or vehicle during 60 days, after the subcutaneous inoculation of 2 × 10(6) units of Leishmania (L.) amazonensis into the footpad.
  3. 03AnimalAnimal study (in vivo)Efficacy outcome

    In infected mice, homeopathic thymulin 5cH increased splenic B1 cell percentage relative to other cell types.

    In plain wordsIn infected mice, homeopathic thymulin 5cH increased spleen B1 cell percentages relative to other cell types.

    Peptide
    Thymulin (serum thymic factor)
    Outcome
    IncreaseSplenic B1 cell percentage
    Study

    mousen: not reported in source

    Leishmania amazonensis-infected male Balb/c mice
    Comparator
    Vehicle
    Outcome group
    Immune response · Immune and inflammation
    Studied dose
    5cH · oral · 60 daysAs given in this study (mouse).

    Source sentences

    Summary
    treated mice presented, chronically, increase in the peritoneal and spleen B1 cells percentage (p = 0.0001) in relation to other cell types
    1 context sentence
    Summary · context
    Male Balb/c mice were orally treated with thymulin 5cH or vehicle during 60 days, after the subcutaneous inoculation of 2 × 10(6) units of Leishmania (L.) amazonensis into the footpad.
  4. 04AnimalAnimal study (in vivo)Efficacy outcome

    In infected mice, homeopathic thymulin 5cH produced a more organized and exuberant local inflammatory response.

    In plain wordsIn infected mice, homeopathic thymulin 5cH increased the organization and extent of local inflammation compared with vehicle.

    Peptide
    Thymulin (serum thymic factor)
    Outcome
    IncreaseLocal inflammatory organization
    Study

    mousen: not reported in source

    Leishmania amazonensis-infected male Balb/c mice
    Comparator
    Vehicle
    Outcome group
    Immune response · Immune and inflammation
    Studied dose
    5cH · oral · 60 daysAs given in this study (mouse).

    Source sentences

    Summary
    more organized and exuberant inflammation response in the infection site
    1 context sentence
    Summary · context
    Male Balb/c mice were orally treated with thymulin 5cH or vehicle during 60 days, after the subcutaneous inoculation of 2 × 10(6) units of Leishmania (L.) amazonensis into the footpad.
  5. 05AnimalAnimal study (in vivo)Efficacy outcome

    In infected mice, homeopathic thymulin 5cH reduced parasites per field within the primary lesion.

    In plain wordsIn infected mice, homeopathic thymulin 5cH reduced lesion parasites compared with vehicle.

    Peptide
    Thymulin (serum thymic factor)
    Outcome
    DecreaseLesion parasite count
    Study

    mousen: not reported in source

    Leishmania amazonensis-infected male Balb/c mice
    Comparator
    Vehicle
    Outcome group
    Infection and antimicrobial activity · Infection
    Studied dose
    5cH · oral · 60 daysAs given in this study (mouse).

    Source sentences

    Summary
    and decrease in the number of parasites per field inside the primary lesion (p = 0.05).
    1 context sentence
    Summary · context
    Male Balb/c mice were orally treated with thymulin 5cH or vehicle during 60 days, after the subcutaneous inoculation of 2 × 10(6) units of Leishmania (L.) amazonensis into the footpad.
  6. 06AnimalAnimal study (in vivo)Efficacy outcome

    In infected mice, homeopathic thymulin 5cH did not change local lymph node histology versus vehicle.

    In plain wordsIn infected mice, homeopathic thymulin 5cH did not change local lymph node structure compared with vehicle.

    Peptide
    Thymulin (serum thymic factor)
    Outcome
    No significant changeLocal lymph node histology
    Study

    mousen: not reported in source

    Leishmania amazonensis-infected male Balb/c mice
    Comparator
    Vehicle
    Outcome group
    Immune response · Immune and inflammation
    Studied dose
    5cH · oral · 60 daysAs given in this study (mouse).

    Source sentences

    Summary
    No difference was seen in local lymph node histology.
    1 context sentence
    Summary · context
    Male Balb/c mice were orally treated with thymulin 5cH or vehicle during 60 days, after the subcutaneous inoculation of 2 × 10(6) units of Leishmania (L.) amazonensis into the footpad.

AI wrote and checked these results. AI can make mistakes, so check important results against the source.

Version history

PepBank keeps every version of the data on this study. Status changes from Retraction Watch, Europe PMC and Crossref are listed with their source.

  1. Version 3Current

    21 Oct 2026, 15:58 UTC

    Study results updated

  2. Version 2

    21 Oct 2026, 13:55 UTC

    Study data updated · source update from Europe PMC

  3. Version 1

    21 Oct 2026, 12:50 UTC

    First added · source update from Europe PMC

Subjects

Terms as the source lists them.

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