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Study · Randomized controlled trial · 2015

2 results

Oxytocin and vasopressin effects on the neural response to social cooperation are modulated by sex in humans.

Feng C, Hackett PD, DeMarco AC, Chen X, Stair S, Haroon E, Ditzen B, Pagnoni G, Rilling JK

Brain imaging and behavior1 Dec 2015Cited by 129 (Europe PMC)

PMID25416642 (opens in a new tab)DOI10.1007/s11682-014-9333-9 (opens in a new tab)PepBankPUB-25416642
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Summary

The text of this summary is not shown here, because the article license does not allow reuse. Read it at the source (opens in a new tab)

Text rights: Publisher copyright. Results still quote short attributed sentences.

Results from this study2

2 results from studies that gave the peptide. 2 results from people.

  1. 01HumanRandomized controlled trialMechanism

    In men playing an iterated Prisoner's Dilemma Game, oxytocin increased the caudate/putamen response to reciprocated cooperation.

    In plain wordsIn men, oxytocin raised brain reward-area activity when a partner cooperated back.

    Peptide
    Oxytocin
    Outcome
    IncreaseCaudate/putamen response to reciprocated cooperation in men
    Study

    n: not reported in source

    Outcome group
    Brain and neuronal activity · Nervous system and cognition
    Studied dose
    24 IU · intranasalAs given in this study (human).

    Source sentences

    Summary
    OT increased the caduate/putamen response among males
    2 context sentences
    Summary · context
    Afterwards, they were imaged with fMRI while playing an iterated Prisoner's Dilemma Game with same-sex partners.
    Summary · context
    In a double-blind, placebo-controlled study, 153 men and 151 women were randomized to receive 24 IU intranasal OT, 20 IU intranasal AVP or placebo.
  2. 02HumanRandomized controlled trialMechanism

    In women playing an iterated Prisoner's Dilemma Game, oxytocin decreased the caudate/putamen response to reciprocated cooperation.

    In plain wordsIn women, oxytocin lowered brain reward-area activity when a partner cooperated back.

    Peptide
    Oxytocin
    Outcome
    DecreaseCaudate/putamen response to reciprocated cooperation in women
    Study

    n: not reported in source

    Outcome group
    Brain and neuronal activity · Nervous system and cognition
    Studied dose
    24 IU · intranasalAs given in this study (human).

    Source sentences

    Summary
    it decreased this response among females
    2 context sentences
    Summary · context
    Afterwards, they were imaged with fMRI while playing an iterated Prisoner's Dilemma Game with same-sex partners.
    Summary · context
    In a double-blind, placebo-controlled study, 153 men and 151 women were randomized to receive 24 IU intranasal OT, 20 IU intranasal AVP or placebo.

AI wrote and checked these results. AI can make mistakes, so check important results against the source.

Version history

PepBank keeps every version of the data on this study. Status changes from Retraction Watch, Europe PMC and Crossref are listed with their source.

  1. Version 2Current

    11 Oct 2026, 01:30 UTC

    Study results updated

  2. Version 1

    9 Oct 2026, 02:50 UTC

    First added · source update from Europe PMC

Subjects

Terms as the source lists them.

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